[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-377581-105":59,"doc-detail-377581-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","modulating-glycolysis-to-improve-cancer-therapy","Modulating Glycolysis to Improve Cancer Therapy","","Cancer cells undergo metabolic reprogramming, shifting toward a glycolysis-dominant profile to sustain survival and satisfy energy and macromolecule demands. This Warburg effect can enhance tumor-promoting conditions and contribute to chemo- and radioresistance. Similar glycolytic changes occur in tumor microenvironment immune cells, creating nutrient competition with cancer cells. Targeting enhanced glycolysis is therefore proposed as a strategy to improve responsiveness to conventional and advanced therapies, yet effective, cancer-cell-specific approaches remain insufficient. Here, metabolic reprogramming is reviewed with emphasis on therapeutic opportunities.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/modulating-glycolysis-to-improve-cancer-therapy/377581/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/modulating-glycolysis-to-improve-cancer-therapy/377581.png","ImageObject",300,407,{"name":92,"@type":93},"anakgang17","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-02","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the Warburg effect and why does it matter for cancer therapy?","Question",{"text":113,"@type":114},"Cancer cells show elevated glycolysis even with functional mitochondria, supporting energy production and anabolic requirements. This metabolic advantage can also promote tumor-friendly microenvironments and treatment resistance, making glycolysis a therapeutic target.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How does glycolysis influence resistance to chemotherapy and radiotherapy?",{"text":118,"@type":114},"Increased glycolytic dependence supports survival programs in cancer cells, including pathways linked to chemo/radio resistance. The review discusses glycolytic modulation as a way to sensitize tumors to conventional treatments.",{"name":120,"@type":111,"acceptedAnswer":121},"Why is targeting glycolysis alone often not sufficient clinically?",{"text":122,"@type":114},"The content notes that glycolytic inhibition by itself lacks effective clinical performance. Combining glycolysis targeting with modalities such as chemotherapy is expected to improve responses and help overcome drug resistance.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},377581,1790379850,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},962090883568,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Review  \nModulating Glycolysis to Improve Cancer Therapy  \nChaithanya Chelakkot 1,†, Vipin Shankar Chelakkot 2,†, Youngkee Shin 3,4 and Kyoung Song 5, *  \nCitation: Chelakkot, C.; Chelakkot, V.S.; Shin, Y.; Song, K. Modulating Glycolysis to Improve Cancer Therapy. Int. J. Mol. Sci. 2023, 24, 2606. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)ijms24032606  \nAcademic Editors: Laura Paleari and Ana Cristina Gonçalves  \nReceived: 15 November 2022  \nRevised: 18 January 2023  \nAccepted: 20 January 2023  \nPublished: 30 January 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Bio-MAX/N-Bio, Seoul National University, Seoul 08826, Republic of Korea  \n2 Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA  \n3 Laboratory of Molecular Pathology and Cancer Genomics, Research Institute of Pharmaceutical Science, Department of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea  \n4 Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea  \n5 College of Pharmacy, Duksung Women's University, Seoul 01366, Republic of Korea  \n* Correspondence: [songseoul17@duksung.ac.kr](songseoul17@duksung.ac.kr)[ ](songseoul17@duksung.ac.kr)† These authors contributed equally to this work.  \nAbstract: Cancer cells undergo metabolic reprogramming and switch to a `glycolysis-dominant'metabolic profile to promote their survival and meet their requirements for energy and macromolecules. This phenomenon, also known as the `Warburg effect,' provides a survival advantage to the cancer cells and make the tumor environment more pro-cancerous. Additionally, the increased glycolytic dependence also promotes chemo/radio resistance. A similar switch to a glycolytic metabolic profile is also shown by the immune cells in the tumor microenvironment, inducing a competition between the cancer cells and the tumor-infiltrating cells over nutrients. Several recent studies have shown that targeting the enhanced glycolysis in cancer cells is a promising strategy to make them more susceptible to treatment with other conventional treatment modalities, including chemotherapy, radiotherapy, hormonal therapy, immunotherapy, and photodynamic therapy. Although several targeting strategies have been developed and several of them are in different stages of pre-clinical and clinical evaluation, there is still a lack of effective strategies to specifically target cancer cell glycolysis to improve treatment efficacy. Herein, we have reviewed our current understanding of the role of metabolic reprogramming in cancer cells and how targeting this phenomenon could be a potential strategy to improve the efficacy of conventional cancer therapy.  \nKeywords: glycolysis; cancer metabolism; combination therapy  \n1. Introduction  \nCancer cells reprogram their metabolism to promote growth, metastasis, and survival. They exhibit an increased glycolytic dependency and show an elevated glucose uptake and fermentation of glucose to lactate to meet the heightened anabolic needs for cancer cell proliferation [1] . Increased glycolysis is not only important for meeting the energy needs of the cells but is also crucial for the generation of metabolic intermediates necessary for macromolecule synthesis in cancer cells [2,3] . This phenomenon, often referred to as the `Warburg effect,' is observed even in the presence of completely functional mitochondria [4] . The Warburg effect has been studied for over 90 years, and several studies have explored the mechanisms governing the increased glyco","cbCaijQ34yfvEWb7","https://ap.wps.com/l/cbCaijQ34yfvEWb7","pdf",1622913,34,"English","# Introduction\n# Modulating Glycolysis to Improve Chemotherapy and Radiotherapy\n## Metabolic modulation and treatment sensitization","[{\"question\":\"What is the Warburg effect and why does it matter for cancer therapy?\",\"answer\":\"Cancer cells show elevated glycolysis even with functional mitochondria, supporting energy production and anabolic requirements. This metabolic advantage can also promote tumor-friendly microenvironments and treatment resistance, making glycolysis a therapeutic target.\"},{\"question\":\"How does glycolysis influence resistance to chemotherapy and radiotherapy?\",\"answer\":\"Increased glycolytic dependence supports survival programs in cancer cells, including pathways linked to chemo/radio resistance. The review discusses glycolytic modulation as a way to sensitize tumors to conventional treatments.\"},{\"question\":\"Why is targeting glycolysis alone often not sufficient clinically?\",\"answer\":\"The content notes that glycolytic inhibition by itself lacks effective clinical performance. Combining glycolysis targeting with modalities such as chemotherapy is expected to improve responses and help overcome drug resistance.\"}]","Modulating Glycolysis to Improve Cancer Therapy | PDF",1790226045,86]