[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-326697-105":59,"doc-detail-326697-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","modulating-ferroptosis-sensitivity-environmental-and-cellular-targets-within-the-tumor-microenvironment","Modulating ferroptosis sensitivity - environmental and cellular targets within the tumor microenvironment","","Ferroptosis, an iron-dependent cell death driven by phospholipid peroxidation, offers promising therapeutic value across diverse cancers. Metabolic pathways linked to ferroptosis operate in both tumor and immune cells, enabling cross-talk between malignant and immune compartments. This review analyzes how tumor microenvironment factors—including nutrient scarcity, hypoxia, and cellular density—reshape ferroptosis sensitivity. It then surveys immunophenotypes and environmental plus metabolic targets aimed at strengthening ferroptosis responsiveness. Tailored ferroptosis interventions and combination strategies matched to specific TME features may improve patient outcomes.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/modulating-ferroptosis-sensitivity-environmental-and-cellular-targets-within-the-tumor-microenvironment/326697/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/modulating-ferroptosis-sensitivity-environmental-and-cellular-targets-within-the-tumor-microenvironment/326697.png","ImageObject",300,407,{"name":92,"@type":93},"Jiven","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is ferroptosis and why is it important for cancer therapy?","Question",{"text":112,"@type":113},"Ferroptosis is a regulated, non-apoptotic form of cell death triggered by iron-dependent phospholipid peroxidation. It has therapeutic potential across multiple cancer types, with evidence supporting efficacy in different tumors.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does the tumor microenvironment influence ferroptosis sensitivity?",{"text":117,"@type":113},"Factors in the tumor microenvironment, including nutrient scarcity, hypoxia, and cellular density, modulate ferroptosis sensitivity. These stresses alter cellular metabolism and can affect anti-tumor immune cell function and therapy resistance.",{"name":119,"@type":110,"acceptedAnswer":120},"What does the review focus on regarding targets and strategies?",{"text":121,"@type":113},"The review examines reciprocal regulation of ferroptosis between cancer and immune cells. It also outlines immunophenotypes and environmental and metabolic targets designed to enhance ferroptosis responsiveness within the tumor microenvironment.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},326697,1790193320,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1099513958607,"https://ap-avatar.wpscdn.com/avatar/100002390cf8733938c?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778829742770036399","Hua et al. Journal of Experimental & Clinical Cancer Research (2024) 43:19 [https://doi.org/10.1186/s13046-023-02925-5](https://doi.org/10.1186/s13046-023-02925-5)  \nJournal of Experimental & Clinical Cancer Research  \nREVIEW Open Access  \nModulating ferroptosis sensitivity:   \nenvironmental and cellular targets within the tumor microenvironment  \nYuze Hua1†, Sen Yang1†, Yalu Zhang1,2†, Jiayi Li1, Mengyi Wang1, Palashate Yeerkenbieke1,3, Quan Liao 1* and Qiaofei Liu 1*  \nAbstract  \nFerroptosis, a novel form of cell death triggered by iron-dependent phospholipid peroxidation, presents significant therapeutic potential across diverse cancer types. Central to cellular metabolism, the metabolic pathways associated with ferroptosis are discernible in both cancerous and immune cells. This review begins by delving into the intricate reciprocal regulation of ferroptosis between cancer and immune cells. It subsequently details how factors within the tumor microenvironment (TME) such as nutrient scarcity, hypoxia, and cellular density modulate ferroptosis sensitivity. We conclude by offering a comprehensive examination of distinct immunophenotypes and environmental and metabolic targets geared towards enhancing ferroptosis responsiveness within the TME. In sum, tailoring precise ferroptosis interventions and combination strategies to suit the unique TME of specific cancers may herald improved patient outcomes.  \nKeywords Ferroptosis, Cellular metabolism, Tumor immunity, Tumor Microenvironment  \n†Yuze Hua, Sen Yang, Yalu Zhang contributed equally to this work.  \n*Correspondence: Quan Liao[lqpumc@126.com](lqpumc@126.com)[ ](lqpumc@126.com)Qiaofei Liu [qfliu@aliyun.com](qfliu@aliyun.com)  \n1Department of General Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 1\\# Shuaifuyuan, Dongcheng District, Beijing 100730, China  \n2Department of General Surgery, Anhui Provincial Hospital, Division of Life Science and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei 230027, China 3Department of General Surgery, Xinjiang Yili Kazak Autonomous Prefecture Friendship Hospital, Xinjiang 835099, China  \nIntroduction  \nCancer development and progression are intricately associated with the multifaceted tumor microenvironment (TME). This dynamic milieu is shaped by aberrant environmental conditions and complex cellular interactions [1, 2]. In the TME, cancer cells interact with various immune cells such as MDSCs, Tregs, and M2-type TAMs. These immunosuppressive cells collectively hinder the metabolism of T cells required for recruitment, infiltration, proliferation, and activation [3–5]. Moreover, The TME is characterized by challenging nutrient deprivation, hypoxia, and acidosis, which significantly influences cellular metabolism. Such conditions compromise the function of anti-tumoral T cells and enhance the resistance to therapeutic interventions [6–10]. It is imperative, therefore, to achieve a deeper understanding of the cellular and environmental interplay in terms of metabolic regulation within the TME. Such knowledge  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the c","cbCaiuAaGZsBp5Ax","https://ap.wps.com/l/cbCaiuAaGZsBp5Ax","pdf",1912255,21,"English","# Abstract\n## Introduction\n## Ferroptosis overview","[{\"question\":\"What is ferroptosis and why is it important for cancer therapy?\",\"answer\":\"Ferroptosis is a regulated, non-apoptotic form of cell death triggered by iron-dependent phospholipid peroxidation. It has therapeutic potential across multiple cancer types, with evidence supporting efficacy in different tumors.\"},{\"question\":\"How does the tumor microenvironment influence ferroptosis sensitivity?\",\"answer\":\"Factors in the tumor microenvironment, including nutrient scarcity, hypoxia, and cellular density, modulate ferroptosis sensitivity. These stresses alter cellular metabolism and can affect anti-tumor immune cell function and therapy resistance.\"},{\"question\":\"What does the review focus on regarding targets and strategies?\",\"answer\":\"The review examines reciprocal regulation of ferroptosis between cancer and immune cells. It also outlines immunophenotypes and environmental and metabolic targets designed to enhance ferroptosis responsiveness within the tumor microenvironment.\"}]","Modulating ferroptosis sensitivity - environmental and cellular targets within the tumor microenvironment | PDF",1789975105,53]