[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-446131-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-446131-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","mmp11-as-a-prognostic-indicator-for-inverted-papilloma-histologic-grade-and-recurrence","MMP11 as a Prognostic Indicator for Inverted Papilloma Histologic Grade and Recurrence","","Inverted papilloma (IP) is a benign yet locally aggressive sinonasal tumor with high recurrence and a risk of malignant transformation to squamous cell carcinoma ex-IP (SCC). Reliable biomarkers predicting recurrence or disease severity are lacking. Matrix metalloproteinase-11 (MMP11) is implicated in tumor progression and extracellular matrix remodeling, with evidence of upregulation during IP transformation. This study evaluates how MMP11 expression relates to histologic severity and recurrence risk.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/mmp11-as-a-prognostic-indicator-for-inverted-papilloma-histologic-grade-and-recurrence/446131/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/mmp11-as-a-prognostic-indicator-for-inverted-papilloma-histologic-grade-and-recurrence/446131.png","ImageObject",300,407,{"name":42,"@type":43},"Taylor Morgan","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",6,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What problem does the study address in inverted papilloma (IP)?","Question",{"text":63,"@type":64},"IP has a high recurrence rate and can transform into squamous cell carcinoma ex-IP, but there are currently no reliable biomarkers to predict recurrence or severity.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was MMP11 expression measured in this study?",{"text":68,"@type":64},"Patient specimens collected retrospectively from 2008 to 2023 were categorized into NST, IPND, IPSD, and SCC, and MMP11 expression was assessed by immunohistochemical staining with quantitative analysis using DAB-Quant software.",{"name":70,"@type":61,"acceptedAnswer":71},"What were the key findings about MMP11 and recurrence?",{"text":72,"@type":64},"MMP11 expression was higher in IPSD and SCC than in IPND, and patients with recurrence showed higher MMP11 in initial resections. High MMP11 expression was associated with a shorter time to recurrence independent of histologic grade.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},446131,1791091504,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,105,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},7,40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":106,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":55,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144,"preview_page_count":4},1099523885336,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","The Laryngoscope  \nORIGINAL REPORT  OPEN ACCESS   \nMMP11 as a Prognostic Indicator for Inverted Papilloma Histologic Grade and Recurrence  \nKush Panara1 | Jadyn Wilensky1 | Alan D. Workman2 | David K. Lerner3 | Alexandria L. Irace1 | Jennifer E. Douglas1,4  | James N. Palmer1 | Nithin D. Adappa1 | Jalal Jalaly5 | Charles C. L. Tong6  | Noam A. Cohen1,4,7 | Michael A. Kohanski1  \n1Department of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA | 2Department of Otolaryngology, Massachusetts Eye and Ear/Harvard Medical School, Boston, Massachusetts, USA | 3Department of Otolaryngology, University of Miami, Miami, Florida, USA | 4Monell Chemical Senses Institute, Philadelphia, Pennsylvania, USA | 5Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA | 6Department of Otolaryngology-Head and Neck Surgery, Lenox Hill Hospital/Long Island Jewish Hospital, New York, New York, USA | 7Corporal Michael J. Crescenz VA Medical Center, Philadelphia, Pennsylvania, USA  \nCorrespondence: Michael A. Kohanski ([michael.kohanski@pennmedicine.upenn.edu](michael.kohanski@pennmedicine.upenn.edu))  \nReceived: 10 June 2025 | Revised: 4 August 2025 | Accepted: 14 August 2025  \nFunding: This work was supported by the American Rhinologic Society (1060942) .  \nKeywords: inverted papilloma | matrix metalloproteinase-11 | recurrence  \nABSTRACT  \nObjectives: Inverted papilloma (IP) is a benign, but locally aggressive sinonasal tumor with a high recurrence rate and potential for malignant transformation into squamous cell carcinoma ex-IP (SCC) . Currently, no reliable biomarkers exist to predict recurrence or severity. Matrix metalloproteinase-11 (MMP11) has been implicated in tumor progression and extracellular matrix remodeling in various malignancies and has been shown to be progressively upregulated in IP transformation. This study investigates the relationship between MMP11 expression and IP histologic severity and recurrence risk.  \nMethods: Patient demographics and tumor characteristics were collected retrospectively at a tertiary care center from 2008 to 2023. Patient specimens were categorized into normal sinus tissue (NST), IP without dysplasia (IPND), IP with severe dysplasia (IPSD), and SCC. Immunohistochemical staining for MMP11 was performed, and quantitative analysis was conducted using DAB-Quant software.  \nResults: A total of 52 patients were included, with a mean follow-up of 68.8 months. MMP11 expression was significantly elevated in IPSD and SCC compared to IPND (36.7% and 36.5% vs. 21.1%, p = 0.02 and p = 0.01) . Patients with recurrence exhibited higher MMP11 expression in their initial resection specimens compared to non-recurrent cases (31.1% vs. 18.1%, p \u003C 0.01) . High MMP11 expression (> 50%) was associated with a shorter time to recurrence (17.5 vs. 32 months, p = 0.03), independent of histologic grade.  \nConclusion: MMP11 expression correlates with increased IP histologic grade, risk of recurrence, and shorter time to recurrence. Elevated MMP11 expression may identify patients at higher risk for recurrence, allowing for targeted surveillance strategies and treatment options.  \nLevel of Evidence: 3.  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2025 The Author(s) . The Laryngoscope published by Wiley Periodicals LLC on behalf of The American Laryngological, Rhinological and Otological Society, Inc.  \nThe Laryngoscope, 2026; 136:113–118 113  \n[https://doi.org/10.1002/lary.70072](https://doi.org/10.1002/lary.70072)  \n1 | Introduction  \nInverted papilloma (IP) is a benign but locally aggressive sinonasal tumor characterized by the proliferation of respiratory epithelium with downward growth into the underlying stromawhile maintaining an ","cbCaidLO6CDXQAC9","https://ap.wps.com/l/cbCaidLO6CDXQAC9","pdf",642559,"English","# ABSTRACT\n## Objectives\n## Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What problem does the study address in inverted papilloma (IP)?\",\"answer\":\"IP has a high recurrence rate and can transform into squamous cell carcinoma ex-IP, but there are currently no reliable biomarkers to predict recurrence or severity.\"},{\"question\":\"How was MMP11 expression measured in this study?\",\"answer\":\"Patient specimens collected retrospectively from 2008 to 2023 were categorized into NST, IPND, IPSD, and SCC, and MMP11 expression was assessed by immunohistochemical staining with quantitative analysis using DAB-Quant software.\"},{\"question\":\"What were the key findings about MMP11 and recurrence?\",\"answer\":\"MMP11 expression was higher in IPSD and SCC than in IPND, and patients with recurrence showed higher MMP11 in initial resections. High MMP11 expression was associated with a shorter time to recurrence independent of histologic grade.\"}]","MMP11 as a Prognostic Indicator for Inverted Papilloma Histologic Grade and Recurrence | PDF",1790714244,15]