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Dysregulated mitochondrial activities are associated with tumor growth and metastasis, especially ovarian carcinoma. The review summarizes cancer-related alterations in mitochondrial function, including mtDNA mutations, ROS production, dynamics, apoptosis, autophagy, and calcium overload. It also discusses how genomic, proteomic, and metabolomic changes in ovarian cancer connect to targeted therapies and biomarkers.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/mitochondrial-dysfunction-route-as-a-possible-biomarker-and-therapy-target-for-human-cancer-review/329816/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/mitochondrial-dysfunction-route-as-a-possible-biomarker-and-therapy-target-for-human-cancer-review/329816.png","ImageObject",300,407,{"name":92,"@type":93},"Aurelia","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are mitochondria important in cancer biology?","Question",{"text":112,"@type":113},"Mitochondria regulate energy production and influence physiological and pathological processes including proliferation, growth, and migration. Their metabolism becomes aberrant during cancer development and spread.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which mitochondrial dysfunction mechanisms are linked to cancer in this review?",{"text":117,"@type":113},"The review highlights modified mitochondrial function involving mtDNA mutations, ROS overproduction, mitochondrial dynamics, apoptosis, autophagy, and calcium excess. These changes support cancer genesis, progression, and metastasis.",{"name":119,"@type":110,"acceptedAnswer":120},"How does mitochondrial dysfunction relate to biomarkers and targeted therapies for ovarian cancer?",{"text":121,"@type":113},"Ovarian cancer is linked to targeted therapies and biomarkers through alterations connected to mitochondrial dysfunction. The review emphasizes targeting ROS and metabolites and considers metabolic pathway changes, including chemo-resistant cancer cells.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},329816,1790193881,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},1099514068365,"https://ap-avatar.wpscdn.com/avatar/10000253d8d9f28188e?x-image-process=image/resize,m_fixed,w_180,h_180&k=1794309523707217728","Biomedical Journal 48 (2025) 100714  \nContents lists available at ScienceDirect Biomedical Journal  \njournal [homepage:](homepage: www.elsevier.com/locate/bj)[ www.elsevier.com/locate/bj](homepage: www.elsevier.com/locate/bj)  \n| Mitochondrial dysfunction route as a possible biomarker and therapy target   for human cancer\u003Cbr>Rawan Al-Fazea, Hoda A. Ahmed b,c, Mohamed A. El-Atawyb,d, Hayat Zagloulb ,\u003Cbr>Eida M. Alshammarie, Mariusz Jaremkof, Abdul-Hamid Emwasg, Gehan M. Nabilh ,\u003Cbr>Demiana H. Hanna c,* \u003Cbr>a Department of Chemistry, Faculty of Science, Taibah University, Almadinah Almunawarah, Saudi Arabia b Chemistry Department, Faculty of Science at Yanbu, Taibah University, Yanbu, Saudi Arabia c Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt\u003Cbr>d Chemistry Department, Faculty of Science, Alexandria University, Ibrahemia, Alexandria, Egypt e Department of Chemistry, College of Sciences, University of Ha’il, Ha’il, Saudi Arabia\u003Cbr>f Biological and Environmental Sciences & Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia g Core Labs., King Abdullah University of Science and Technology, Thuwal, Saudi Arabia\u003Cbr>h Department of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia |  |  |\n| --- | --- | --- |\n| A R T I C L E I N F O |  | A B S T R A C T |\n| Keywords:\u003Cbr>Mitochondria\u003Cbr>Ovarian carcinoma\u003Cbr>Mitochondrial dysfunction pathway Biomarkers\u003Cbr>Targeted therapies |  | Mitochondria are vital organelles found within living cells and have signalling, biosynthetic, and bioenergetic functions. Mitochondria play a crucial role in metabolic reprogramming, which is a characteristic of cancer cells and allows them to ensure a steady supply of proteins, nucleotides, and lipids to enable rapid proliferation and development. Their dysregulated activities have been associated with the growth and metastasis of different kinds of human cancer, particularly ovarian carcinoma. In this review, we briefly demonstrated the modified mitochondrial function in cancer, including mutations in mitochondrial DNA (mtDNA), reactive oxygen species (ROS) production, dynamics, apoptosis of cells, autophagy, and calcium excess to maintain cancer genesis, progression, and metastasis. Furthermore, the mitochondrial dysfunction pathway for some genomic, proteomic, and metabolomics modifications in ovarian cancer has been studied. Additionally, ovarian cancer has been linked to targeted therapies and biomarkers found through various alteration processes underlying mitochondrial dysfunction, notably targeting (ROS), metabolites, rewind metabolic pathways, and chemo-resistant ovarian carcinoma cells. |\n\n1. Introduction  \nThe mitochondria constitute the “energy center” of the cell, producing over 90 % ATP. Most recently, it has been recognized that mitochondria, as a vital organelle in our bodies, play a vital function in controlling many different kinds of physiological and pathological processes, especially proliferation, growth, and migration, as well as functions related to cancer genesis, progression, and metastasis [1–3].  \nMitochondria serve as the target core for multiple energy metabolism regulators. Multiple research investigations have confirmed that, throughout the development and spread of cancer, aberrant mitochondrial metabolism (e.g., alterations in glucose, fatty acid, and amino acid  \nmetabolism) is frequently seen [4]. In addition, mitochondria serve asthe cellular factories that create reactive oxygen molecules, which will stimulate tumor malignancy through the reactive oxygen species (ROS) dysregulation pathway [5].  \nThe Bcl-2 protein family regulates apoptosis by modulating mitochondrial permeability, which is a key route in the process of apoptosis. Proteins that suppress apoptosis, such as B-cell lymphoma-2 (Bcl-2) and B-cell lymphoma-extra-large (Bcl-xL), exist in mitochondrial outer me","cbCaieH6kStr0bLQ","https://ap.wps.com/l/cbCaieH6kStr0bLQ","pdf",994252,"English","# Introduction\n## Mitochondria as the cell energy center\n## Aberrant mitochondrial metabolism in cancer\n## ROS dysregulation and tumor malignancy\n## Apoptosis regulation via Bcl-2 family\n## Calcium homeostasis and mitochondrial dysfunction\n## Mitophagy and mitochondrial quality control","[{\"question\":\"Why are mitochondria important in cancer biology?\",\"answer\":\"Mitochondria regulate energy production and influence physiological and pathological processes including proliferation, growth, and migration. Their metabolism becomes aberrant during cancer development and spread.\"},{\"question\":\"Which mitochondrial dysfunction mechanisms are linked to cancer in this review?\",\"answer\":\"The review highlights modified mitochondrial function involving mtDNA mutations, ROS overproduction, mitochondrial dynamics, apoptosis, autophagy, and calcium excess. These changes support cancer genesis, progression, and metastasis.\"},{\"question\":\"How does mitochondrial dysfunction relate to biomarkers and targeted therapies for ovarian cancer?\",\"answer\":\"Ovarian cancer is linked to targeted therapies and biomarkers through alterations connected to mitochondrial dysfunction. The review emphasizes targeting ROS and metabolites and considers metabolic pathway changes, including chemo-resistant cancer cells.\"}]","Mitochondrial dysfunction route as a possible biomarker and therapy target for human cancer - Review | PDF",1789985708,23]