[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-356824-105":59,"doc-detail-356824-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","mitochondrial-dynamics-and-cancer-mechanisms-and-targeted-therapy","Mitochondrial dynamics and cancer: mechanisms and targeted therapy","","Mitochondria are key eukaryotic organelles that maintain cellular energy balance and functional integrity via coordinated dynamics, including fission, fusion, autophagy, and transport, driven by precise molecular control. Healthy cells maintain mitochondrial network equilibrium for quality control and metabolic coordination. Cancer cells show multidimensional dysregulation such as hyperactive fission, defective fusion, and compensatory respiratory chain assembly factor upregulation, producing morphology–function decoupling. These changes reprogram metabolism, promote proliferation, suppress apoptosis, enhance migration and drug resistance, and support immune evasion. This review summarizes mechanisms, cancer-linked dysregulation, tumor behavior impact, and current targeted therapeutic strategies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/mitochondrial-dynamics-and-cancer-mechanisms-and-targeted-therapy/356824/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/mitochondrial-dynamics-and-cancer-mechanisms-and-targeted-therapy/356824.png","ImageObject",300,407,{"name":92,"@type":93},"Terk","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What mitochondrial processes are highlighted as core regulators in the review?","Question",{"text":112,"@type":113},"The review highlights dynamic processes including mitochondrial fission, fusion, autophagy, and transport, supported by precise molecular mechanisms.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do cancer cells differ from healthy cells regarding mitochondrial dynamics?",{"text":117,"@type":113},"Cancer cells exhibit multidimensional dysregulation such as hyperactive fission, impaired fusion, and compensatory upregulation of respiratory chain assembly factors, leading to morphology–function decoupling.",{"name":119,"@type":110,"acceptedAnswer":120},"What tumor behaviors are driven by altered mitochondrial dynamics?",{"text":121,"@type":113},"Alterations drive tumor progression by reprogramming metabolism, promoting proliferation, inhibiting apoptosis, enhancing migration and drug resistance, and facilitating immune evasion.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},356824,1790183259,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1099525198933,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Cell Biol Toxicol (2026) 42:66  \n[https://doi.org/10.1007/s10565-026-10174-3](https://doi.org/10.1007/s10565-026-10174-3)  \nMitochondrial dynamics and cancer: mechanismsand targeted therapy  \nAixin Wang · Xinyu Ye · Yumeng Zhao · Chao Zhang  \nReceived: 2 December 2025 / Accepted: 23 March 2026 © The Author(s) 2026  \nAbstract Mitochondria, as key organelles in eukaryotic cells, regulate cellular energy homeostasis and functional integrity through dynamic processes, including fission, fusion, autophagy, and transport, underpinned by precise molecular mechanisms. In healthy cells, the equilibrium of mitochondrial dynamics ensures network quality control and metabolic coordination. In contrast, cancer cells exhibit multi-dimensional dysregulation characterized by hyperactive fission, impaired fusion, and compensatory upregulation of respiratory chain assembly factors, creating a state of “morphology-function decoupling”. These alterations drive tumor progression by reprogramming cellular metabolism, promoting proliferation, inhibiting apoptosis, enhancing migration and drug resistance, and facilitating immune evasion. This review elucidates the molecular mechanisms underlying mitochondrial dynamics, their dysregulation in cancer, and their influence on tumor behavior, while also addressing the core challenges of current  \nA. Wang · X. Ye · Y. Zhao · C. Zhang  \nNational Center for Clinical Laboratories, Beijing Hospital, National Center for Gerontology; National Clinical Research Center for Gerontology; The Key Laboratory of Geriatrics of NHC; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China  \nA. Wang · X. Ye · Y. Zhao · C. Zhang (*)  \nChinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China  \ne-mail: [zc_mdy@163.com](zc_mdy@163.com); [chaozhang@nccl.org.cn](chaozhang@nccl.org.cn)  \ntargeted therapeutic strategies and the novel therapeutic paradigm of “network remodeling”, offering new insights into tumor biology and precision cancer therapy.  \nKeywords Mitochondrial dynamics · Cancer · Mitochondrial fission · Mitochondrial fusion · Targeted therapy  \nAbbreviations  \nΔΨm  \nAkt  \nAMPKAtg8  \nARG1  \nATP  \nBax  \nBak  \nBcl-2L13  \nBLCA  \nBRCA  \nCAF  \nCAMK1α  \nCAMKII  \nCaspase-3/9 CDK1  \nCDK5  \ncGAS-STING  \nMitochondrial membrane potential Protein kinase B  \nAMP-activated protein kinase Autophagy-related gene 8  \nArginase 1  \nAdenosine triphosphate Bcl-2-associated X protein Bcl-2 antagonist/killer 1  \nBCL2-like protein 13  \nBladder cancer Breast cancer  \nCancer-associated fibroblast Calcium/calmodulin-dependent protein kinase 1α  \nCalcium/calmodulin-dependent protein kinase II  \nCysteine-aspartic acid protease-3/9 Cyclin-dependent kinase 1  \nCyclin-dependent kinase 5  \nCyclic GMP-AMP synthase-Stimulator of interferon genes  \nCMT2A  \nCOA1  \nCOAD  \nCOX  \nCOX18  \nDCs  \nDDP  \nDrp1/DNM1LECM  \nEMT  \nER  \nERK1/2  \nEVs  \nF-actin  \nFAK  \nFAO  \nFis1  \nFUNDC1  \nGLUT1  \nGTP  \nGTPase  \nHCCHDAC6  \nHIF1α  \nIMM  \nIMS  \nIL-10/IL-12  \nINF2  \nKIF5  \nLC3  \nLIR  \nL-OPA1  \nLUAD  \nMAPK  \nMARCH5  \nMHC-I  \nMdivi-1  \nMEFs  \nMEK  \nMff  \nMFN  \nMIRO  \nCharcot-Marie-Tooth disease type 2A  \nCytochrome c oxidase assembly factor 1  \nColon adenocarcinoma Cytochrome c oxidase COX assembly protein 18  \nDendritic cells Cisplatin  \nDynamin-related protein 1  \nExtracellular matrix  \nEpithelial-mesenchymal transition Endoplasmic reticulum Extracellular regulated kinase 1/2  \nExtracellular vesicles Filamentous actin Focal adhesion kinase Fatty acid oxidation Fission protein 1  \nFUN14 domain containing 1  \nGlucose transporter 1  \nGuanosine triphosphate  \nGuanosine triphosphatase Hepatocellular carcinoma Histone deacetylase 6  \nHypoxia-inducible factor 1α Inner mitochondrial membrane Intermembrane space Interleukin-10/Interleukin-12  \nInverted formin 2  \nKinesin family member 5  \nMicrotubule-associated protein 1 light chain 3  \nLC3-interacting regions  \nLong isoform optic atrophy 1  \nLung adenocarcinoma  \nMitogen-act","cbCaioD85d0lALjb","https://ap.wps.com/l/cbCaioD85d0lALjb","pdf",1308345,23,"English","# Introduction\n# Mitochondrial dynamics mechanisms\n# Dysregulation of mitochondrial dynamics in cancer\n# Effects on tumor progression and immune evasion\n# Targeted therapeutic strategies and network remodeling","[{\"question\":\"What mitochondrial processes are highlighted as core regulators in the review?\",\"answer\":\"The review highlights dynamic processes including mitochondrial fission, fusion, autophagy, and transport, supported by precise molecular mechanisms.\"},{\"question\":\"How do cancer cells differ from healthy cells regarding mitochondrial dynamics?\",\"answer\":\"Cancer cells exhibit multidimensional dysregulation such as hyperactive fission, impaired fusion, and compensatory upregulation of respiratory chain assembly factors, leading to morphology–function decoupling.\"},{\"question\":\"What tumor behaviors are driven by altered mitochondrial dynamics?\",\"answer\":\"Alterations drive tumor progression by reprogramming metabolism, promoting proliferation, inhibiting apoptosis, enhancing migration and drug resistance, and facilitating immune evasion.\"}]","Mitochondrial dynamics and cancer: mechanisms and targeted therapy | PDF",1790127498,58]