[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-353310-105":59,"doc-detail-353310-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","mitochondria-damaging-self-reporting-probe-for-cancer-therapy","Mitochondria-Damaging Self-Reporting Probe for Cancer Therapy","","Mitochondrial damage triggered by chemotherapeutic agents through disruption of mitochondrial membrane potential (ΔΨm) remains a central obstacle in drug development and evaluation. Assessment with commercially available fluorescent probes is often unreliable because dyes can interfere with, obscure, or exaggerate drug-induced dysfunction, producing misleading conclusions. This work presents cationic chemotherapeutic small molecules (DPPs) with intrinsic fluorescence migration-based self-reporting that noninvasively monitors drug action without external probes. DPP-1 and DPP-2 induce mitochondrial dysfunction, ROS overproduction, and selective apoptosis, and show concentration-dependent mitochondrial-to-nuclear translocation for real-time subcellular visualization; in vivo results confirm strong tumor inhibition with minimal systemic toxicity.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/mitochondria-damaging-self-reporting-probe-for-cancer-therapy/353310/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/mitochondria-damaging-self-reporting-probe-for-cancer-therapy/353310.png","ImageObject",300,407,{"name":92,"@type":93},"kopisore","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is evaluating ΔΨm-targeting drugs with commercial fluorescent probes unreliable?","Question",{"text":112,"@type":113},"Commercial dyes can interfere with, mask, or artificially amplify drug-induced mitochondrial dysfunction, leading to misleading conclusions and translational failure.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What is the core feature of the reported DPP compounds?",{"text":117,"@type":113},"They are cationic chemotherapeutic small molecules with intrinsic fluorescence migration-based self-reporting capability, enabling direct and non-invasive monitoring of drug action without external probes.",{"name":119,"@type":110,"acceptedAnswer":120},"How do DPP-1 and DPP-2 demonstrate therapeutic progression at the subcellular level?",{"text":121,"@type":113},"They disrupt mitochondrial function, generate excessive reactive oxygen species, induce highly selective apoptosis, and show concentration-dependent mitochondrial-to-nuclear translocation for real-time visualization.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},353310,1790196684,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962090880963,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Angewandte Chemie International Edition  \nHow to cite: Angew. Chem. Int. Ed. 2026, 65, e8302619 [doi.org/10.1002/anie.8302619](doi.org/10.1002/anie.8302619)  \n RESEARCH ARTICLE   \nMitochondria-Damaging Self-Reporting Probe for Cancer Therapy  \nHai Xu1   Yura Lee2  Sanghee Yoon3   Yun Wang4  Yejin Cho2  Seongyu Choi2  Lu Lu5  Hua Zhang5  Sun Choi3   Ki Taek Nam2   Juyoung Yoon1, 6   \n1 Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, Republic of Korea  2 Department of Biomedical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of Korea  3 Global AI Drug Discovery Center, College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, Republic of Korea  4 Laboratory of Human Disease and Immunotherapies, West China Hospital, Sichuan University, Chengdu, P. R. China  5 School of Chemistry and Chemical Engineering, Henan International Joint Laboratory of Smart Molecules and Identification and Diagnostic Functions, Henan Normal University, Henan, P. R. China  6 Graduate Program in Innovative Biomaterials Convergence, Ewha Womans University, Seoul, Republic of Korea  \nCorrespondence: Hua Zhang ([zhh1106@htu.edu.cn](zhh1106@htu.edu.cn))  Sun Choi (sunchoi@ewha.ac.kr)  Ki Taek Nam (kitaek@yuhs.ac)  Juyoung Yoon ([jyoon@ewha.ac.kr](jyoon@ewha.ac.kr))  \nReceived: 15 February 2026  Revised: 23 April 2026  Accepted: 20 May 2026  \nKeywords: cancer therapy | fluorescence imaging | mitochondria | self-reporting probe  \nABSTRACT  \nMitochondrial damage induced by chemotherapeutic agents through disruption of the mitochondrial membrane potential (ΔΨm ) remains a central challenge in drug development and evaluation. However, the assessment of ΔΨm-targeting drugs using commercially available fluorescent probes is often unreliable, as these dyes can interfere with, mask, or artificially amplify druginduced mitochondrial dysfunction, frequently resulting in misleading conclusions and translational failure. Herein, we report a class of cationic chemotherapeutic small molecules (DPPs) possessing intrinsic fluorescence migration-based self-reporting capability, which enables direct and non-invasive monitoring of drug action without the need for external probes. Among them, DPP-1 and DPP-2 disrupt mitochondrial function, trigger excessive reactive oxygen species generation, and induce highly selective apoptosis. Remarkably, both compounds exhibit concentration-dependent mitochondrial-to-nuclear translocation, enabling the real-time visualization of therapeutic progression at the subcellular level. In vivo studies further confirm their potent tumor growth inhibition and negligible systemic toxicity effects. This self-reporting mitochondria-targeted chemotherapeutic platform provides a highly promising strategy for integrated cancer diagnosis and precision therapy.  \n1  Introduction  \nCancer cells exhibit rapid proliferation, abnormal energy metabolism, and resistance to apoptotic signals, making them highly resistant to conventional therapeutic agents [1–3] . Asthe central hub of energy production and signal regulation, mitochondria participate in adenosine triphosphate (ATP)  \nsynthesis, reactive oxygen species (ROS) modulation, and lipid metabolism, while also playing key roles in intrinsic apoptosis, cell cycle regulation, and DNA damage response [4–7]; therefore, they have emerged as a crucial target of anticancer drug development strategies [8, 9] . In recent years, a variety of mitochondria-targeted compounds have shown potent cytotoxicity toward multiple cancer cell types by disrupting the  \nHai Xu, Yura Lee, and Sanghee Yoon contributed equally to this work.  \nThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.  \n©","cbCaij4g8pJB3xi0","https://ap.wps.com/l/cbCaij4g8pJB3xi0","pdf",13458668,11,"English","# Introduction\n## Mitochondria as a cancer drug target\n## Fluorescent probes for mitochondrial damage monitoring\n## Limitations of external-probe fluorescence readouts\n## Goal: linking drug action with real-time reporting","[{\"question\":\"Why is evaluating ΔΨm-targeting drugs with commercial fluorescent probes unreliable?\",\"answer\":\"Commercial dyes can interfere with, mask, or artificially amplify drug-induced mitochondrial dysfunction, leading to misleading conclusions and translational failure.\"},{\"question\":\"What is the core feature of the reported DPP compounds?\",\"answer\":\"They are cationic chemotherapeutic small molecules with intrinsic fluorescence migration-based self-reporting capability, enabling direct and non-invasive monitoring of drug action without external probes.\"},{\"question\":\"How do DPP-1 and DPP-2 demonstrate therapeutic progression at the subcellular level?\",\"answer\":\"They disrupt mitochondrial function, generate excessive reactive oxygen species, induce highly selective apoptosis, and show concentration-dependent mitochondrial-to-nuclear translocation for real-time visualization.\"}]","Mitochondria-Damaging Self-Reporting Probe for Cancer Therapy | PDF",1790104647,28]