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Emphasizes mechanisms spanning energy metabolism, apoptosis, inflammation, and fibrosis, with featured work describing mitochondrial dysfunction as an initiator and amplifier of chronic kidney disease progression. Summarizes evidence on therapeutic restoration of mitochondrial homeostasis via pathways such as AMPK/SIRT1 and AMPK/PGC-1α, plus targeting apoptosis, oxidative stress, and inflammatory signaling to protect renal tissue.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/mitochondria-an-old-new-link-in-the-progression-of-renal-disease-editorial/449334/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/mitochondria-an-old-new-link-in-the-progression-of-renal-disease-editorial/449334.png","ImageObject",300,407,{"name":92,"@type":93},"Blitz","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-04","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":81},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What role do mitochondria play in renal disease according to this editorial?","Question",{"text":112,"@type":113},"Mitochondria regulate multiple renal processes including energy metabolism, apoptosis, inflammation, and fibrosis. The editorial presents mitochondrial dysfunction as central to both progression and worsening of renal conditions.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How is mitochondrial dysfunction linked to chronic kidney disease progression?",{"text":117,"@type":113},"Mitochondrial impairment contributes to oxidative stress, reduced ATP production, and altered metabolic signaling, which drive tubular injury and interstitial fibrosis. Accumulation of reactive oxygen species further perpetuates renal decline.",{"name":119,"@type":110,"acceptedAnswer":120},"What therapeutic approaches are discussed to restore mitochondrial function in kidney disease?",{"text":121,"@type":113},"The editorial highlights agents and pathways that support mitochondrial homeostasis and biogenesis, including AMPK/SIRT1 and AMPK/PGC-1α mechanisms. It also references interventions targeting mitochondrial-related inflammatory cascades and lipid-driven mitochondrial damage.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},449334,1790815862,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":81,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":19,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":52},24464137899374,"https://us-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","Renal FailuRe  \n2025, VOl. 47, nO. 1, 2602986  \n[https://doi.org/10.1080/0886022X.2025.2602986](https://doi.org/10.1080/0886022X.2025.2602986)  \nEditorial     \nMitochondria – an old–new link in the progression of renal disease  \nMonika Gooz   \nDepartment of Regenerative Medicine and Cell Biology, Medical university of South Carolina, Charleston, SC, uSa ARTICLE HISTORY received 17 october 2025; revised 4 december 2025; accepted 8 december 2025  \nKEYWORDS Mitochondrial dysfunction; chronic kidney disease (CKd); acute kidney injury (aKi); renal fibrosis; diabetic kidney disease; mitochondria-targeted therapy  \nIntroduction  \nMitochondria, long recognized as the cell’s powerhouse, have emerged as pivotal regulators of renal health and disease. once considered secondary players in kidney pathology, these dynamic organelles are now at the forefront of nephrology research. the collection of articles in this issue, titled ‘Mitochondria – an old–new link in the progression of renal disease,’ underscores the multifaceted roles of mitochondria in renal physiology and pathophysiology, from energy metabolism and apoptosis to inflammation and fibrosis.  \nFeatured articles  \nthe kidney is among the most energy-demanding organs in the body, second only to the heart in oxygen consumption [1] . renal tubular cells, particularly in the proximal tubule, rely heavily on mitochondrial oxidative phosphorylation to sustain active transport processes essential for filtration and reabsorption [2]. thus, mitochondrial integrity is central to maintaining renal function. the article ‘Mitochondrial dysfunction: the hidden catalyst in chronic kidney disease progression’ [3] highlights how mitochondrial impairment precedes and exacerbates chronic kidney disease (CKd) . Mitochondrial dysfunction contributes to oxidative stress, impaired atP production, and altered metabolic signaling, all of which drive tubular injury and interstitial fibrosis [4,5] . the accumulation of reactive oxygen species (roS) and mitochondrial dNa damage further perpetuates renal decline [6] .  \nin ‘Piezo1 facilitates the initiation and progression of renal fibrosis by mediating cell apoptosis and mitochondrial dysfunction’ [7], the mechanosensitive ion channel Piezo1 is implicated in renal fibrosis through its influence on mitochondrial pathways. Piezo1 activation promotes calcium influx, triggering mitochondrial permeability transition and apoptosis [8] .  \nSeveral articles in this collection explore therapeutic agents that restore mitochondrial homeostasis.‘Caffeic acid phenethyl ester restores mitochondrial homeostasis against peritoneal fibrosis induced by peritoneal dialysis through the AMPK/SIRT1 pathway’ [9] demonstrates how natural compounds can activate mitochondrial biogenesis and antioxidant defenses. the aMPK/Sirt1 axis is a well-established regulator of mitochondrial function, promoting fatty acid oxidation and reducing inflammation [10] . Similarly,‘Sodium butyrate improves mitochondrial function and kidney tissue injury in diabetic kidney disease via the AMPK/PGC-1α pathway’ [11] reinforces the role of mitochondrial biogenesis in renal protection. PGC-1α, a master regulator of mitochondrial metabolism, is downregulated in diabetic nephropathy, and its restoration mitigates renal injury [12, 13] .  \nCONTACT Monika Gooz  [beckm@musc.edu](beckm@musc.edu)  Department of Regenerative Medicine and Cell Biology, Medical university of South Carolina, Charleston, SC, uSa  \n© 2026 The author(s) . Published by informa uK limited, trading as Taylor & Francis Group  \nThis is an Open access article distributed under the terms of the Creative Commons attribution-nonCommercial license ([http://creativecommons.org/licenses/](http://creativecommons.org/licenses/)[ ](http://creativecommons.org/licenses/)[by-nc/4.0/](by-nc/4.0/)), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The termson which th","cbCaiuuNCnPNRkSX","https://ap.wps.com/l/cbCaiuuNCnPNRkSX","pdf",411375,"English","# Introduction\n# Featured articles\n## Mitochondrial dysfunction in chronic kidney disease\n## Mechanisms linking mitochondria to renal fibrosis\n## Mitochondria-targeted therapeutic strategies\n## Inflammation and acute kidney injury\n## Lipid metabolism, CD36, and diabetic kidney disease\n## Bibliometric perspective and research trends\n## Mitochondrial dynamics and mitophagy","[{\"question\":\"What role do mitochondria play in renal disease according to this editorial?\",\"answer\":\"Mitochondria regulate multiple renal processes including energy metabolism, apoptosis, inflammation, and fibrosis. The editorial presents mitochondrial dysfunction as central to both progression and worsening of renal conditions.\"},{\"question\":\"How is mitochondrial dysfunction linked to chronic kidney disease progression?\",\"answer\":\"Mitochondrial impairment contributes to oxidative stress, reduced ATP production, and altered metabolic signaling, which drive tubular injury and interstitial fibrosis. Accumulation of reactive oxygen species further perpetuates renal decline.\"},{\"question\":\"What therapeutic approaches are discussed to restore mitochondrial function in kidney disease?\",\"answer\":\"The editorial highlights agents and pathways that support mitochondrial homeostasis and biogenesis, including AMPK/SIRT1 and AMPK/PGC-1α mechanisms. It also references interventions targeting mitochondrial-related inflammatory cascades and lipid-driven mitochondrial damage.\"}]","Mitochondria - an old-new link in the progression of renal disease - Editorial | PDF",1790729907]