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Existing diagnostics for virus-associated GI malignancies often miss infections during subclinical or pre-cancerous stages. Viral RNA-loaded exosomes are proposed as stable, specific, non-invasive biomarkers, enabling earlier detection and improving monitoring compared with conventional methods.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/missing-link-viral-rna-signatures-in-circulating-exosomes-as-early-diagnostic-biomarkers-for-gastrointestinal-cancers/366583/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/missing-link-viral-rna-signatures-in-circulating-exosomes-as-early-diagnostic-biomarkers-for-gastrointestinal-cancers/366583.png","ImageObject",300,407,{"name":92,"@type":93},"Kurz","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main idea of this editorial?","Question",{"text":112,"@type":113},"It argues that viral RNA signatures inside circulating exosomes could serve as a missing link for early diagnosis of gastrointestinal cancers, especially those associated with oncogenic viruses.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Why do current diagnostic methods have limitations?",{"text":117,"@type":113},"Current approaches for virus-associated GI malignancies often fail to detect infections at subclinical or pre-cancerous stages, leading to diagnosis at more advanced disease stages.",{"name":119,"@type":110,"acceptedAnswer":120},"How are viral RNA-loaded exosomes expected to help?",{"text":121,"@type":113},"They may provide stable, specific, non-invasive biomarkers for early detection and for distinguishing malignant from benign conditions, with potential insight into tumor progression and therapeutic targeting.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},366583,1790575444,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},2336478945635,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","| W | J | G | O | World Journal of\u003Cbr>Gastrointestinal Oncology |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastrointest Oncol 2025 September 15; 17(9): 110110  \nDOI: 10.4251/wjgo.v17.i9.110110 ISSN 1948-5204 (online)  \nEDITORIAL  \nMissing link: Viral RNA signatures in circulating exosomes as early diagnostic biomarkers for gastrointestinal cancers  \nMahmoud Darweesh, Saeed Mohammadi  \nSpecialty type: Oncology  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade B, Grade B, Grade C  \nNovelty: Grade A, Grade B, Grade C  \nCreativity or Innovation: Grade B, Grade B, Grade C  \nScientific Significance: Grade B, Grade B, Grade C  \nP-Reviewer: Corovic I, MD, Researcher, Serbia; Ždralević M, PhD, Assistant Professor, Montenegro  \nReceived: May 30, 2025  \nRevised: July 2, 2025  \nAccepted: August 13, 2025  \nPublished online: September 15, 2025  \nProcessing time: 105 Days and 23.5 Hours  \nMahmoud Darweesh, Saeed Mohammadi, Natural and Medical Sciences Research Center, University of Nizwa, Nizwa 616, Ad Dakhiliyah, Oman  \nMahmoud Darweesh, Department of Microbiology and Immunology, Faculty of Pharmacy, Alazhr University, Assiut 71524, Egypt  \nSaeed Mohammadi, Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan 49341-74515, Iran  \nCo-first authors: Mahmoud Darweesh and Saeed Mohammadi.  \nCorresponding author: Saeed Mohammadi, PhD, Assistant Professor, Natural and Medical Sciences Research Center, University of Nizwa, Birkat Al Mouz University of Nizwa Campus, Nizwa 616, Ad Dakhiliyah, [Oman.](Oman. s.mohammadi@unizwa.edu.om)[ s.mohammadi@unizwa.edu.om](Oman. s.mohammadi@unizwa.edu.om)  \nAbstract  \nThis editorial highlights the critical role of viral RNA signatures encapsulated within circulating exosomes as a potential missing link in the early diagnosis of gastrointestinal (GI) cancers. Current diagnostic methods for virus-associated GI malignancies often fall short in detecting infections at subclinical or pre-cancerous stages. We propose that viral RNA-loaded exosomes, by offering stable, specific, and non-invasive biomarkers, can bridge this gap and revolutionize early detection compared to conventional approaches. As highlighted by Zhang et al in their recent review, viral infections, such as hepatitis B and C viruses, EpsteinBarr virus, and human papillomavirus, are well-established contributors to the pathogenesis of various GI malignancies. However, current diagnostic methods often underperform in detecting these infections at subclinical or pre-cancerous stages. We highlight the shared points between virology, exosome biology, and oncology, reinforcing the importance of viral RNA-loaded exosomes as a “missing link” in the early detection of virus-associated GI cancers. We also discuss current challenges, translational opportunities, and the requirements for clinical validation of these promising biomarkers.  \nKey Words: Exosomes; Viral RNA; Liquid biopsy; Gastrointestinal cancer; Early detection; Epstein-Barr virus; Hepatitis B virus; Hepatitis C virus; Biomarkers; Noncoding RNA  \n©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.  \n WJGO  [https://www.wjgnet.com](https://www.wjgnet.com) 1 September 15, 2025  Volume 17  Issue 9   \nDarweesh M et al. Exosomal viral RNA in GI cancer diagnosis  \nCore Tip: Early and accurate diagnostic markers are essential for managing gastrointestinal (GI) cancers, as their prognosis is linked to the stage of detection. This editorial emphasizes the potential of virus-enriched exosomes as a novel, non-invasive diagnostic tool for early detection and monitoring of GI cancers, particularly those associated with oncogenic viruses like Epstein-Barr virus and hepatitis B virus. The viral RNA signatures within these ","cbCaih7rJ4XS7Ys0","https://ap.wps.com/l/cbCaih7rJ4XS7Ys0","pdf",418839,"English","# Abstract\n## Introduction\n## Core Tip","[{\"question\":\"What is the main idea of this editorial?\",\"answer\":\"It argues that viral RNA signatures inside circulating exosomes could serve as a missing link for early diagnosis of gastrointestinal cancers, especially those associated with oncogenic viruses.\"},{\"question\":\"Why do current diagnostic methods have limitations?\",\"answer\":\"Current approaches for virus-associated GI malignancies often fail to detect infections at subclinical or pre-cancerous stages, leading to diagnosis at more advanced disease stages.\"},{\"question\":\"How are viral RNA-loaded exosomes expected to help?\",\"answer\":\"They may provide stable, specific, non-invasive biomarkers for early detection and for distinguishing malignant from benign conditions, with potential insight into tumor progression and therapeutic targeting.\"}]","Missing link - Viral RNA signatures in circulating exosomes as early diagnostic biomarkers for gastrointestinal cancers | PDF",1790166237,18]