[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-326819-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-326819-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","mir-4492-a-new-potential-microrna-for-cancer-diagnosis-and-treatment-a-mini-review","MiR-4492, a New Potential MicroRNA for Cancer Diagnosis and Treatment - A Mini Review","","Review summarizing miR-4492 as a newly highlighted microRNA with potential roles in cancer diagnosis and treatment. Discusses how diagnostic and therapeutic targeting of noncoding RNAs, especially microRNAs and long noncoding RNAs, offers an approach for malignancy management. Highlights miR-4492 upregulation of tumor-associated genes and its involvement across multiple cancer types, emphasizing the need to clarify its mechanisms to support improved biomarker and therapeutic target development.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/mir-4492-a-new-potential-microrna-for-cancer-diagnosis-and-treatment-a-mini-review/326819/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/mir-4492-a-new-potential-microrna-for-cancer-diagnosis-and-treatment-a-mini-review/326819.png","ImageObject",300,407,{"name":42,"@type":43},"Himbo","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is miR-4492 and why is it important in cancer research?","Question",{"text":63,"@type":64},"miR-4492 is presented as a new potential microRNA involved in cancer-related gene regulation. It is discussed as a promising candidate for diagnostic biomarkers and therapeutic targets.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which tumor-associated genes are reported as upregulated by miR-4492?",{"text":68,"@type":64},"The text lists upregulated genes in tumor tissues, including ROMO1, HLA-G, NKIRAS2, FOXK1, and UBE2C.",{"name":70,"@type":61,"acceptedAnswer":71},"For which cancer types does miR-4492 involvement have been reported?",{"text":72,"@type":64},"The document cites several cancers, including breast cancer, bladder cancer, osteosarcoma, glioblastoma multiforme, hepatocellular carcinoma, colorectal cancer, and ovarian cancer.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},326819,1790680331,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":102,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144},687197100911,"https://ap-avatar.wpscdn.com/avatar/a000239b6f1da00475?x-image-process=image/resize,m_fixed,w_180,h_180&k=1785132997149421697","Review Article  \n[www.cmj.ac.kr](www.cmj.ac.kr)  \nMiR-4492, a New Potential MicroRNA for Cancer Diagnosis and Treatment: A Mini Review  \nAida Alizamir1, Mohammad Amin Amini2, Ashkan Karbasi2, and Mehdi Beyrami2,*  \nDepartments of 1Pathology and 2Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran  \nThere is no doubt that the incidence of cancer sufferers is rising in the world, and it is estimated that in the next several decades, the number of people suffering from malignancies or the cancer rate will double. Diagnostic and therapeutic targeting of noncoding RNAs (ncRNAs), especially microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), represent an excellent approach for cancer diagnosis and treatment, as well as many other diseases. One of the latest miRNAs is miR-4492, upregulating some genes in tumor tissues including ROMO1, HLA-G, NKIRAS2, FOXK1, and UBE2C. It represents an attractant example of a miRNA acting at multiple levels to affect the same malignancy hallmark. Based on the studies, miR-4492 plays a key role in several cancers such as, breast cancer, bladder cancer, osteosarcoma, glioblastoma multiforme, hepatocellular carcinoma, colorectal cancer, and ovarian cancer. Putting it alltogether, identifying the precise mechanisms of miR-4492 in the pathogenesis of cancer, could pave the way to find better diagnostic and therapeutic strategies for cancer sufferers. For this reason, it might be a novel potential diagnostic biomarker and therapeutic target for neoplasms.  \nKeyWords: MicroRNAs; Long Noncoding RNA; Neoplasms; miR-4492  \nThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ([http://creativecommons.org/licenses/by-nc/4.0](http://creativecommons.org/licenses/by-nc/4.0)) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.  \nArticle History:  \nReceived November 19, 2023 Revised January 10, 2024  \nAccepted January 14, 2024  \nCorresponding Author:  \nMehdi Beyrami  \nDepartment of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Shahid Fahmideh Blvd. ,  \nHamadan 6517838678, Iran Tel: +98-8138380572  \nFax: +98-8132512972  \n[E-mail: me.beirami@edu.umsha.ac.ir](E-mail: me.beirami@edu.umsha.ac.ir)  \nINTRODUCTION  \nOne of the most important responsible for the majority of global deaths is non-communicable diseases,1 and cancer is estimated become as the major death cause and the most critical obstacle to enhancing life span all over the world in the 21st century. Neoplasms include several diseases in which the major factor is the uncontrolled cell proliferation, invasion, and diffusion of cancerous cells from primary spot to the other organs.2 In a malignant tumor, cells are immensely dissimilar to typical cells, both physiologically and morphologically.2 It is proven that cancers are the second major cause of mortality in developing nations and, also are the major death cause in industrialized nations.2 The essential genes that participate in neoplasms are generally categorized into five major groups: 1) proto-carcinogens (proto-oncogenes), 2) DNA repairing genes, 3) tumor suppressor genes, 4) genes associated with apoptosis, and 5) genes associated with telomere homeostasis.2 Furthermore,  \nthe other crucial factor that scientists consider as a critical part of beginning and deteriorating numerous diseases, especially neoplasms is increasing oxidative stress.2-4 Scientists and clinical practitioners have applied numerous biomarkers for therapeutic, diagnostic, and prognostic assessment of neoplasms. Due to heterogeneity in the precise molecular and cellular mechanisms in cancerous cells, novel biomarkers are always required.  \nNoncoding RNAs (ncRNAs) are originated from the greater constituent of the genome that do not encode any amino acid sequence though create noncoding transcripts that a","cbCaibhBwO2EhgV7","https://ap.wps.com/l/cbCaibhBwO2EhgV7","pdf",304329,"English","# INTRODUCTION\n## Noncoding RNAs and microRNA biology\n## miR-4492 and neoplasms","[{\"question\":\"What is miR-4492 and why is it important in cancer research?\",\"answer\":\"miR-4492 is presented as a new potential microRNA involved in cancer-related gene regulation. It is discussed as a promising candidate for diagnostic biomarkers and therapeutic targets.\"},{\"question\":\"Which tumor-associated genes are reported as upregulated by miR-4492?\",\"answer\":\"The text lists upregulated genes in tumor tissues, including ROMO1, HLA-G, NKIRAS2, FOXK1, and UBE2C.\"},{\"question\":\"For which cancer types does miR-4492 involvement have been reported?\",\"answer\":\"The document cites several cancers, including breast cancer, bladder cancer, osteosarcoma, glioblastoma multiforme, hepatocellular carcinoma, colorectal cancer, and ovarian cancer.\"}]","MiR-4492, a New Potential MicroRNA for Cancer Diagnosis and Treatment - A Mini Review | PDF",1789975433,15]