[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-337031-105":59,"doc-detail-337031-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","mir-22-3p-as-a-promising-predictor-of-nutritional-deficiencies-in-patients-with-head-and-neck-cancer-abstract","MiR-22-3p as a Promising Predictor of Nutritional Deficiencies in Patients with Head and Neck Cancer - Abstract","","MicroRNA miR-22-3p is evaluated as a molecular marker for nutritional deficiency risk and as a prognostic factor in head and neck cancer patients receiving intensity-modulated radiation therapy. In a cohort of 56 advanced cases treated between 2014 and 2017, miR-22-3p was measured from peripheral blood before treatment. Underweight, moderately/severely malnourished, and critical weight loss groups showed significantly lower miR-22-3p expression, with weak associations to stage, BMI, and CRP. Validation is recommended in further studies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/mir-22-3p-as-a-promising-predictor-of-nutritional-deficiencies-in-patients-with-head-and-neck-cancer-abstract/337031/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/mir-22-3p-as-a-promising-predictor-of-nutritional-deficiencies-in-patients-with-head-and-neck-cancer-abstract/337031.png","ImageObject",300,407,{"name":92,"@type":93},"Quinn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main biomarker evaluated in this study?","Question",{"text":112,"@type":113},"The study evaluates microRNA miR-22-3p measured from peripheral blood before treatment as a potential predictor of nutritional deficiencies.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were miR-22-3p levels related to underweight and malnutrition?",{"text":117,"@type":113},"Underweight patients showed significantly lower miR-22-3p expression than non-underweight patients, and moderately or severely malnourished patients also had reduced miR-22-3p compared with well-nourished individuals.",{"name":119,"@type":110,"acceptedAnswer":120},"Does miR-22-3p correlate with clinical factors like tumor stage and inflammation?",{"text":121,"@type":113},"Weak correlations were reported between miR-22-3p levels and cancer stage, BMI, and C-reactive protein (CRP), with lower miR-22-3p associated with advanced tumor stages and higher CRP levels.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},337031,1790113070,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962075114765,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nMiR-22-3p as a promising predictor of nutritional deficiencies inpatients with head and neck cancer subjected to intensity-modulated radiation therapy  \nKatarzyna Chawrylak1,2􀀍, Iwona Homa-Mlak3, Marcin Mazurek3, Ewelina Płecha1, Anna Brzozowska4, Teresa Małecka-Massalska3 & Radosław Mlak5  \nHead and neck cancer (HNC) is the seventh most common cancer globally, with 20–60% of patients experiencing nutritional deficiencies. Recent studies indicate that microRNAs (miRNAs) may serve as molecular markers for malnutrition. This study evaluated miR-22-3p as a potential predictor of nutritional deficiencies and a prognostic factor in HNC patients undergoing intensity-modulated radiation therapy (IMRT). From 2014 to 2017, fifty-six advanced HNC patients at the Medical University of Lublin received IMRT, with miR-22-3p levels measured from peripheral blood before treatment. Statistical analysis using MedCalc 15.8 revealed that underweight patients had significantly lower miR-22-3p expression compared to non-underweight patients (0.89 vs. 2.47; p = 0.0233) . Moderately or severely malnourished patients also showed reduced miR-22-3p levels compared to well-nourished individuals (1.42 vs. 11.04; p = 0.026). Additionally, patients with critical weight loss (CWL) had significantly lower miR-22-3p levels than those without CWL (0.96 vs. 4.91; p = 0.0015) . Weak correlations were found between miR-22-3p levels, cancer stage, body mass index (BMI), and C-reactive protein (CRP), with lower miR-22-3p levels linked to advanced tumor stages and higher CRP levels. This study suggests miR-22-3p as a biomarker for nutritional deficiency risk in HNC patients, though further research is needed to validate its predictive capacity.  \nKeywords Head and neck cancer, Malnutrition, Intensity-modulated radiation therapy, miR-22-3p, Nutritional deficiencies, Critical weight loss  \nHead and neck cancer (HNC) ranks as the seventh most prevalent cancer globally, with an estimated 0.66– 1.1 million new cases annually, contributing to approximately 325,000-500,000 annual deaths1,2. HNC encompasses a diverse array of tumors affecting the upper respiratory and upper gastrointestinal tracts1. In addition to smoking, acknowledged as the primary risk factor for HNC3, others identified encompass: regular high alcohol consumption, genetic predisposition, laryngopharyngeal reflux, areca (betel) nut chewing, marijuana usage, inadequate oral hygiene and prior exposure to radiotherapy (RT)4,5. Squamous cell carcinoma (SCC) originating in the lining of the mouth, pharynx, and larynx, accounts for up to 90% of HNC cases6. Currently, also infection agents i.e. Human Papillomavirus (HPV), especially HPV16/18 accounting for nearly 90% of HPVrelated oropharyngeal squamous cell carcinoma (OSCC) and Epstein-Barr virus (EBV) linked particularly with nasopharyngeal cancer (NPC) are recognized as significant factors involved in HNC etiopathogenesis7,8. As per the National Comprehensive Cancer Network (NCCN) Guidelines, about 30–40% of patients with early-stage cancer (stage I or II) are typically recommended for single-modality treatment, either surgery or RT. Surgery is often the preferred choice for oral cavity and paranasal sinus cancers, while RT, with or without chemotherapy  \n1Student Scientific Group, Department of Human Physiology, Medical University of Lublin, Lublin 20-080, Poland.  \n2Department of Surgical Oncology, Medical University of Lublin, Radziwiłłowska 13 St, Lublin 20-080, Poland.  \n3Department of Human Physiology of Chair of Preclinical Sciences, Medical University of Lublin, Lublin 20-080, Poland. 4II Department of Radiotherapy, Center of Oncology of the Lublin Region St. John of Dukla, Lublin 20-090, Poland. 5Department of Laboratory Diagnostics, Medical University of Lublin, Doktora Witolda Chodźki 1 Str, Lublin 20-093, Poland. 􀀍 email: [katchawrylak@gmail.com](katchawrylak@gmail.com)","cbCaif05pTLzo5Ax","https://ap.wps.com/l/cbCaif05pTLzo5Ax","pdf",2344142,17,"English","# Background\n## Head and neck cancer and malnutrition\n## Treatment context and nutritional impacts\n# Study design and cohort\n## IMRT and pre-treatment biomarker measurement\n# Results\n## Associations with weight status and malnutrition\n## Links to tumor stage, BMI, and CRP\n# Conclusion","[{\"question\":\"What is the main biomarker evaluated in this study?\",\"answer\":\"The study evaluates microRNA miR-22-3p measured from peripheral blood before treatment as a potential predictor of nutritional deficiencies.\"},{\"question\":\"How were miR-22-3p levels related to underweight and malnutrition?\",\"answer\":\"Underweight patients showed significantly lower miR-22-3p expression than non-underweight patients, and moderately or severely malnourished patients also had reduced miR-22-3p compared with well-nourished individuals.\"},{\"question\":\"Does miR-22-3p correlate with clinical factors like tumor stage and inflammation?\",\"answer\":\"Weak correlations were reported between miR-22-3p levels and cancer stage, BMI, and C-reactive protein (CRP), with lower miR-22-3p associated with advanced tumor stages and higher CRP levels.\"}]","MiR-22-3p as a Promising Predictor of Nutritional Deficiencies in Patients with Head and Neck Cancer - Abstract | PDF",1790017445,43]