[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-375748-105":59,"doc-detail-375748-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","mir-1247-3p-regulation-of-ccnd1-affects-chemoresistance-in-colorectal-cancer","miR-1247-3p regulation of CCND1 affects chemoresistance in colorectal cancer","","Chemotherapy using 5-fluorouracil and cisplatin often fails in colorectal cancer because drug resistance develops. Research increasingly links abnormal microRNA expression to resistance across cancer types. This study investigates the small non-coding RNA miR-1247-3p in colorectal cancer and its relationship to DDP resistance. miR-1247-3p shows reduced expression in resistant CRC cells, while its target cyclin D1 (CCND1) is increased. Modulating CCND1 via miR-1247-3p decreases resistance and promotes apoptosis, suggesting a potential strategy to overcome CRC chemoresistance.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/mir-1247-3p-regulation-of-ccnd1-affects-chemoresistance-in-colorectal-cancer/375748/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/mir-1247-3p-regulation-of-ccnd1-affects-chemoresistance-in-colorectal-cancer/375748.png","ImageObject",300,407,{"name":92,"@type":93},"Aurelia","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What problem does the study address in colorectal cancer treatment?","Question",{"text":112,"@type":113},"The study targets chemotherapy failure driven by the emergence of drug resistance, especially resistance to cisplatin combined with 5-fluorouracil.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How is miR-1247-3p linked to drug resistance in CRC?",{"text":117,"@type":113},"The findings show a significant decrease in miR-1247-3p expression in CRC cells, particularly those resistant to drugs, and a functional connection to DDP resistance.",{"name":119,"@type":110,"acceptedAnswer":120},"What mechanism did the study propose involving CCND1?",{"text":121,"@type":113},"miR-1247-3p negatively regulates cyclin D1 (CCND1). By modulating CCND1 through miR-1247-3p, drug resistance is reduced and apoptosis is promoted.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},375748,1790245980,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1099514068365,"https://ap-avatar.wpscdn.com/avatar/10000253d8d9f28188e?_k=1776742907772140068","PLOS ONE  \nOPEN ACCESS  \nCitation: Wang D, Wang J, Yao F, Xie Z, Wu J, Chen H, et al. (2024) miR-1247-3p regulation of CCND1 affects chemoresistance in colorectal cancer. PLoS ONE 19(12): e0309979 . [https://doi](https://doi). org/10 .1371/journal.pone.0309979  \nEditor: Abdul Rauf Shakoori, University of the Punjab, PAKISTAN  \nReceived: May 27, 2024  \nAccepted: August 20, 2024  \nPublished: December 31, 2024  \nCopyright: © 2024 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.  \nData Availability Statement: Availability of data and materials: GSE128446 is from the GEO dataset. (GEO Accession viewer ([nih.gov](nih.gov))) GSE190951 is from the GEO dataset. (GEO Accession viewer ([nih.gov](nih.gov))) RNA-Seq data and clinical data for colorectal cancer patients were obtained from the TCGA database. (GDC Analysis Center ([cancer.gov](cancer.gov))) RNA sequencing data generated in this study were submitted to the GEO database (GSE173606) . (GEO Accession viewer ([nih.gov](nih.gov))) All raw data and Western blot images were deposited in [https://data.mendeley.com/](https://data.mendeley.com/)[ ](https://data.mendeley.com/)[drafts/ftwszf2zmx](drafts/ftwszf2zmx) (10.17632/ftwszf2zmx.1).  \nRESEARCH ARTICLE  \nmiR-1247-3p regulation of CCND1 affects chemoresistance in colorectal cancer  \nDequan Wang1☯, Jielian Wang2☯, Fei Yao3, Zhufu Xie1, Jianze Wu1, Huiguang Chen1, Qingming Wu1,4 *  \n1 Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Institute of Infection, Immunology and Tumor Microenvironment, School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China, 2 Department of Internal Medicine, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, China, 3 College of Health Medicine, China Three Gorges University, Yichang, Hubei, P. R. China, 4 Department of Gastroenterology, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, Hubei, China  \n☯ These authors contributed equally to this work.  \n* [wuhe9224@sina.com](wuhe9224@sina.com)  \nAbstract  \nThe effectiveness of chemotherapy involving 5-fluorouracil and cisplatin (DDP) for the treatment of colorectal cancer (CRC) is often limited due to the emergence of drug resistance. An increasing body of research highlights the crucial role of abnormally expressed microRNAs (miR/miRNAs) in fostering drug resistance in various types of cancer. The present study was the first to explore the potential roles and mechanisms of the small non-coding RNA miR-1247-3p in CRC, particularly its association with DDP resistance in CRC. The findings of the current study revealed a significant decrease in miR-1247-3p expression in CRC cells, especially those resistant to drugs. By contrast, there was a marked increase in the expression of cyclin D1 (CCND1), a known target gene of miR-1247-3p that is negatively regulated by this miRNA. By modulating CCND1, miR-1247-3p can effectively reduce drug resistance and promote apoptosis in CRC cells, suggesting that miR-1247-3p could potentially reduce chemotherapy resistance by targeting CCND1 . These results highlight the pivotal role of miR-1247-3p in reducing chemotherapy resistance through the inhibition of CCND1, providing insight into a promising therapeutic strategy for overcoming CRC resistance.  \nIntroduction  \nColorectal cancer (CRC) is one of the most common cancers globally, with increasing rates of morbidity and mortality, and a poor prognosis [ 1, 2] . For patients with advanced CRC, adjuvant chemotherapy involving fluorouracil-and platinum-based agents is the recommended standard of care according to various treatment guidelines. However, the effectiveness of conventional chemotherapy in advanced CRC is limited, with chemoresistance being a marked factor leading to poor patient ","cbCaimPATQUpjaLN","https://ap.wps.com/l/cbCaimPATQUpjaLN","pdf",1735542,15,"English","# Abstract\n# Introduction","[{\"question\":\"What problem does the study address in colorectal cancer treatment?\",\"answer\":\"The study targets chemotherapy failure driven by the emergence of drug resistance, especially resistance to cisplatin combined with 5-fluorouracil.\"},{\"question\":\"How is miR-1247-3p linked to drug resistance in CRC?\",\"answer\":\"The findings show a significant decrease in miR-1247-3p expression in CRC cells, particularly those resistant to drugs, and a functional connection to DDP resistance.\"},{\"question\":\"What mechanism did the study propose involving CCND1?\",\"answer\":\"miR-1247-3p negatively regulates cyclin D1 (CCND1). By modulating CCND1 through miR-1247-3p, drug resistance is reduced and apoptosis is promoted.\"}]","miR-1247-3p regulation of CCND1 affects chemoresistance in colorectal cancer | PDF",1790215996,38]