[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-336240-105":59,"doc-detail-336240-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","minimally-invasive-treatment-of-early-good-prognosis-breast-canceris-this-feasible","Minimally invasive treatment of early, good prognosis breast cancer—is this feasible?","","Breast cancer screening programmes frequently identify early, good-prognosis cases, creating meaningful treatment burden and health-cost implications. Emerging research supports minimally invasive techniques that may allow many women to avoid surgical intervention. This review evaluates published evidence for vacuum-assisted excision, cryoablation, and radiofrequency ablation, weighing risks and benefits while considering ongoing trials. Current data are promising, suggesting a future shift toward minimally invasive management as criteria and follow-up protocols mature.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/minimally-invasive-treatment-of-early-good-prognosis-breast-canceris-this-feasible/336240/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/minimally-invasive-treatment-of-early-good-prognosis-breast-canceris-this-feasible/336240.png","ImageObject",300,407,{"name":92,"@type":93},"Aurora","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is treatment burden an issue for early, good-prognosis breast cancers detected through screening?","Question",{"text":112,"@type":113},"Screening programmes detect early, good-prognosis cancers that often still require surgical and adjuvant treatments, contributing to significant treatment burden and health-cost implications. Overdiagnosis of small tumours can further increase unnecessary treatment.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What minimally invasive techniques are reviewed for these breast cancers?",{"text":117,"@type":113},"The review covers vacuum-assisted excision, cryoablation, and radiofrequency ablation. It assesses the risks and benefits of each technique in the context of early, good-prognosis disease.",{"name":119,"@type":110,"acceptedAnswer":120},"What factors help identify small tumours likely to have a good prognosis?",{"text":121,"@type":113},"Smaller tumours with biologically favourable characteristics—such as oestrogen/progesterone receptor positivity and HER2-negative status—have very high 10-year survival. Molecular assays like the Oncotype Dx 21 gene assay help stratify distant recurrence risk.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},336240,1790201122,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46},4810365810221,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Minimally invasive treatment of early, good prognosis breast cancer—is this feasible?  \nMhairi Mactier  , BMSc, MBChB1, Stuart A. McIntosh  , MBChB, PhD2, 􀀃 , Nisha Sharma  , BSc, MSc, MBChB3  \n1Golden Jubilee National Hospital, Clydebank G81 4DY, United Kingdom  \n2 Patrick G Johnston Centre for Cancer Research, Queen’s University Belfast, Belfast BT9 7AE, United Kingdom 3 Breast Unit, St James Hospital, Leeds LS9 7TF, United Kingdom  \n􀀃 Corresponding author: Mhairi Mactier, BMSc, MBChB, Golden Jubilee National Hospital, Agamemnon St, Clydebank G81 4DY, United Kingdom (mhairi. [mactier2@nhs.scot](mactier2@nhs.scot)) and Stuart A. McIntosh, MBChB, PhD, Patrick G Johnston Centre for Cancer Research, Queen’s University Belfast, 97 Lisburn Road, Belfast BT9 7AE, United Kingdom ([s.mcintosh@qub.ac.uk](s.mcintosh@qub.ac.uk))  \nAbstract  \nBreast cancer screening programmes frequently detect early, good prognosis breast cancers with significant treatment burden for patients, and associated health-cost implications. Emerging evidence suggests a role for minimally invasive techniques in the management of these patients enabling many women to avoid surgical intervention. Minimally invasive techniques include vacuum-assisted excision, cryoablation, and radiofrequency ablation. We review published evidence in relation to the risks and benefits of each technique and discuss ongoing trials. Data to date are promising, and we predict a trend towards minimally invasive treatment for early, good-prognosis breast cancer as technical skills, suitability criteria, and follow-up protocols are established.  \nKeywords: breast cancer; breast screening; minimally invasive surgery; vacuum-assisted excision; cryotherapy; radiofrequency ablation.  \nBackground  \nIn the United Kingdom, women aged 50 to \u003C71years are invited for screening mammography every three years. The risks and benefits of breast screening have long been controversial, resulting in the publication of the UK Independent Panel Report on Breast Cancer Screening in 2012.1 This review examined published literature and concluded that for every three cases of breast cancer diagnosed and treated, one breast cancer death was prevented. Although the incidence of breast cancer was increasing prior to screening, the introduction of mammographic screening programmes resulted in a marked increase in the incidence of smaller (\u003C2 cm) tumours, with a smaller decrease seen in the incidence of larger (􀀕2 cm) tumours.2 Further analysis of mortality trends suggests that women with smaller tumours are more likely to be overdiagnosed rather than having earlier detection of tumours which are destined to become large, with “overdiagnosis” defined as a diagnosis of a tumour which never becomes clinically apparent during a patient’s lifetime. Overdiagnosis may be due to either non-progressive disease, or due to indolent cancers which progress so slowly that competing causes of death negate their clinical significance, with estimates of the contribution of each cause varying with age. The consequence of the “overdiagnosis” of such small tumours is a treatment burden resulting from surgical and adjuvant treatments which may have minimal survival benefit. However, it is not currently possible to reliably identify individual tumours as overdiagnosed.  \nThe reduction in breast cancer mortality seen in the decades since the initiation of screening may be attributable to  \nimprovements in systemic therapy rather than being entirely due to earlier detection of disease.3 Smaller tumours showing biologically favourable characteristics (oestrogen/progesterone receptor positive, HER2 negative tumours) are associated with almost 100% survival at 10 years.4 Our understanding of tumour biology and associated prognosis have been further improved by the introduction of molecular assays. For example, the Oncotype Dx 21 gene assay was developed in 2004 and is used to calculate the risk of distant recurrence at 10 years.5 The test as","cbCaibFIk7npc4Ux","https://ap.wps.com/l/cbCaibFIk7npc4Ux","pdf",1006273,"English","# Background\n## Screening and overdiagnosis\n## Prognostic tools and risk stratification\n## Need to tailor treatment\n# Minimally invasive treatment options\n## Vacuum-assisted excision\n## Cryoablation\n## Radiofrequency ablation\n# Evidence review and ongoing trials","[{\"question\":\"Why is treatment burden an issue for early, good-prognosis breast cancers detected through screening?\",\"answer\":\"Screening programmes detect early, good-prognosis cancers that often still require surgical and adjuvant treatments, contributing to significant treatment burden and health-cost implications. Overdiagnosis of small tumours can further increase unnecessary treatment.\"},{\"question\":\"What minimally invasive techniques are reviewed for these breast cancers?\",\"answer\":\"The review covers vacuum-assisted excision, cryoablation, and radiofrequency ablation. It assesses the risks and benefits of each technique in the context of early, good-prognosis disease.\"},{\"question\":\"What factors help identify small tumours likely to have a good prognosis?\",\"answer\":\"Smaller tumours with biologically favourable characteristics—such as oestrogen/progesterone receptor positivity and HER2-negative status—have very high 10-year survival. Molecular assays like the Oncotype Dx 21 gene assay help stratify distant recurrence risk.\"}]","Minimally invasive treatment of early, good prognosis breast cancer—is this feasible? | PDF",1790014228]