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Methods: Embase, Cochrane Library, PubMed, MEDLINE, and Web of Science were searched for studies comparing robotic/laparoscopic MIS with open thoracotomy; pooled standard mean differences and relative risks with 95% CIs were computed. Results: MIS shortened operative time and reduced hospital stay, without clear differences in multiple clinical and recurrence outcomes. Conclusion: MIS offers operative-time and stay benefits for locally advanced lung cancer; additional high-quality studies are required.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/minimally-invasive-surgery-versus-thoracotomy-for-locally-advanced-lung-cancers-a-systematic-review-and-meta-analysis/352278/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/minimally-invasive-surgery-versus-thoracotomy-for-locally-advanced-lung-cancers-a-systematic-review-and-meta-analysis/352278.png","ImageObject",300,407,{"name":92,"@type":93},"Lucas Martin","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What comparison does the systematic review evaluate for locally advanced lung cancer?","Question",{"text":112,"@type":113},"It compares minimally invasive surgery (robotic and laparoscopic) with conventional open thoracotomy in patients with locally advanced lung cancer.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which outcomes favored minimally invasive surgery in the pooled results?",{"text":117,"@type":113},"Minimally invasive surgery showed significantly shorter operative time and reduced hospital stay compared with open thoracotomy.",{"name":119,"@type":110,"acceptedAnswer":120},"Were there significant differences in postoperative or recurrence-related outcomes?",{"text":121,"@type":113},"No statistically significant differences were observed for blood loss, ICU days, chest tube duration, lymph node measures, complications, ARDS, atrial arrhythmia, chylothorax, prolonged air leak, pneumonia, and overall recurrence.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},352278,1790190476,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},8796095360427,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","®  \nSystematic Review and Meta-Analysis   \nMinimally invasive surgery versus thoracotomy for locally advanced lung cancers  \nA systematic review and meta-analysis  \nYuanfa Chen, MDa , Cheng Chen, MDa , Dan Ran, MDb , Ya Lu, MDc , Dong Liu, MDd ,*  \n\n| Abstract\u003Cbr>Background: Locally advanced lung cancer is generally regarded as a relative contraindication for minimally invasive surgical approaches. The comparative outcomes between minimally invasive techniques and conventional open thoracotomy in this specific patient population have not been adequately investigated through rigorous clinical studies.\u003Cbr>Methods: We systematically searched Embase, Cochrane Library, PubMed, MEDLINE, and Web of Science for studies comparing minimally invasive (robotic and laparoscopic) approaches with conventional open thoracotomy. Pooled standard mean differences, relative risks, and 95% confidence intervals were calculated. The study protocol was registered with PROSPERO (CRD42024526598) .\u003Cbr>Results: There were 7819 participants including 15 articles. Compared with open thoracotomy, patients undergoing minimally invasive surgery (MIS) demonstrated significantly shorter operative time (SMD = 0. 13; 95% CI = 0.01–0.24; I2=49 .9%, P = .036) and reduced hospital stay (SMD = −0 . 19; 95% CI = −0.24 to −0 . 14; I2=45 .6%, P \u003C .001) . However, no significant differences were observed in blood loss, ICU days, chest tube duration, lymph node resected, lymph node total stations, complications, acute respiratory distress syndrome (ARDS), atrial arrhythmia, chylothorax, prolonged air leak, pneumonia, and overall recurrence. Conclusion: MIS demonstrates significant advantages over thoracotomy in terms of operative time and hospital stay for locally advanced lung cancer. However, no statistically significant differences were observed in blood loss, ICU days, chest tube duration, lymph nodes resected, lymph nodes total stations, complications, ARDS, atrial arrhythmia, chylothorax, prolonged air leak, pneumonia, and overall recurrence. More high-quality literature is needed to be included in the research in the future. Abbreviations: ARDS = acute respiratory distress syndrome, CIs = confidence intervals, CRP = C-reactive protein, MIS = minimally invasive surgery, NOS = Newcastle-Ottawa Scale, PRISMA = preferred reporting items for systematic reviews and the meta-analysis, RR = relative risk, SMD = standard mean difference, VATS = video-assisted thoracic surgery. |\n| --- |\n| Keywords: locally advanced lung cancers, meta-analysis, minimally invasive surgery, thoracotomy |\n\n1. Introduction  \nThe optimal treatment approach for locally advanced nonsmall cell lung cancer ((LA-NSCLC)) patients have always been controversial. Numerous studies have demonstrated that neoadjuvant chemotherapy combined with surgery provides survival benefits without increasing postoperative complication rates. [1–3] While extensive literature confirms comparable safety and efficacy between minimally invasive surgery (MIS) and conventional thoracotomy for early-to-mid stage lung cancer, with additional advantages in reduced trauma, faster  \nrecovery, and improved quality of life. [4,5] Minimally invasive approaches were historically considered contraindicated for LA-NSCLC due to technical challenges and equipment limitations. [6] With technological advancements and refined surgical techniques, thoracic surgeons have progressively expanded minimally invasive applications to LA-NSCLC. Utilizing modern minimally invasive platforms, complex procedures including bronchial sleeve resection, pulmonary artery reconstruction, carinal reconstruction, and combined bronchovascular double-sleeve resections have been successfully  \nThis work was supported by the Project of Chengdu Municipal Health Commission (2022124, 2023611) and Scientific Research Foundation of Health and Family Planning Commission of Sichuan Province (20PJ236).  \nThe authors declare that there is no involving informed consent. The ","cbCairDQPfREN6fo","https://ap.wps.com/l/cbCairDQPfREN6fo","pdf",710282,13,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What comparison does the systematic review evaluate for locally advanced lung cancer?\",\"answer\":\"It compares minimally invasive surgery (robotic and laparoscopic) with conventional open thoracotomy in patients with locally advanced lung cancer.\"},{\"question\":\"Which outcomes favored minimally invasive surgery in the pooled results?\",\"answer\":\"Minimally invasive surgery showed significantly shorter operative time and reduced hospital stay compared with open thoracotomy.\"},{\"question\":\"Were there significant differences in postoperative or recurrence-related outcomes?\",\"answer\":\"No statistically significant differences were observed for blood loss, ICU days, chest tube duration, lymph node measures, complications, ARDS, atrial arrhythmia, chylothorax, prolonged air leak, pneumonia, and overall recurrence.\"}]","Minimally invasive surgery versus thoracotomy for locally advanced lung cancers - A systematic review and meta-analysis | PDF",1790098680,33]