[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-458832-105":59,"doc-detail-458832-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","microstructure-and-gene-expression-influence-gyrification-in-amyotrophic-lateral-sclerosis","Microstructure and gene expression influence gyrification in amyotrophic lateral sclerosis","","Amyotrophic lateral sclerosis is a progressive, fatal neurodegenerative disease affecting upper and lower motor neurons. This study examined structural and diffusion MRI in 60 ALS patients and 60 matched controls to characterize cortical gyrification and related white-matter microstructure, linking imaging measures to motor and cognitive performance. Fractional anisotropy mediated effects between local gyrification and functional disability. Transcriptomic integration with the Allen Human Brain Atlas highlighted convergence with ALS gene expression, including TARDBP and C9orf72.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/microstructure-and-gene-expression-influence-gyrification-in-amyotrophic-lateral-sclerosis/458832/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/microstructure-and-gene-expression-influence-gyrification-in-amyotrophic-lateral-sclerosis/458832.png","ImageObject",300,407,{"name":92,"@type":93},"Alexandar","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What imaging methods were used to study gyrification in ALS?","Question",{"text":112,"@type":113},"The study used structural and diffusion MRI to measure cortical gyrification and white-matter microstructure in ALS patients and matched controls.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which brain regions showed altered local gyrification index in ALS patients?",{"text":117,"@type":113},"Patients had a significant reduction in local gyrification index in bilateral precentral and postcentral gyri, left middle frontal gyrus, and left superior parietal lobule.",{"name":119,"@type":110,"acceptedAnswer":120},"How did fractional anisotropy relate gyrification to functional disability?",{"text":121,"@type":113},"Mediation analysis indicated that fractional anisotropy partially accounted for the relationship between local gyrification index and functional disability, implicating disrupted white-matter pathways in clinical impact.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},458832,1790789536,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},962090768658,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","[https://doi.org/10.1093/braincomms/fcaf491](https://doi.org/10.1093/braincomms/fcaf491) BRAIN COMMUNICATIONS 2026: fcaf491 | 1  \nBRAIN COMMUNICATIONS  \nMicrostructure and gene expression influence gyrification in amyotrophic lateral sclerosis  \nYihan Jiang, 1,2,† Yan Fu,3,† Xinyu Song,4,† Xueying Wang,5 Jianyu Li,2 Luqi Cheng,6 Yifan Chen,2 Yuanchao Zhang, 1,2,7 Junling Wang,4,8,9, 10, 11, 12 Xiaoping Yi 13, 14, 15 and Lena Palaniyappan 16  \n† These authors contributed equally to this work.  \nAmyotrophic lateral sclerosis is a fatal neurodegenerative disease involving progressive degeneration of upper and lower motor neurons. Beyond well-established grey and white matter pathology, alterations in cortical gyrification have recently been observed, yet their clinical relevance and molecular underpinnings remain to be understood. Here, we investigated this premise by examining its microstructural and transcriptional basis in 60 patients with amyotrophic lateral sclerosis (median age = 55, range = 25–72 years) and 60 matched controls (median age = 56, range = 27–72 years) using structural and diffusion MRI. Patients exhibited a significant reduction in local gyrification index within bilateral precentral and postcentral gyri, left middle frontal gyrus and left superior parietal lobule. This was accompanied by reduced fractional anisotropy in the white matter tracts, primarily involving the corticospinal tract and corpus callosum. Higher local gyrification index and fractional anisotropy values were associated with better motor function as measured by the Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised, and local gyrification index also showed positive associations with global cognitive status. A mediation analysis indicated that fractional anisotropy partially accounted for the relationship between local gyrification index and functional disability, suggesting that disrupted white matter pathways contribute to the clinical impact of gyrification changes. To explore underlying mechanisms, we integrated neuroimaging findings with transcriptomic data from the Allen Human Brain Atlas. Regions of reduced local gyrification index showed spatial convergence with cortical expression of amyotrophic lateral sclerosis-related genes such as TARDBP and C9orf72, enriched for biological processes related to protein aggregation, axon guidance and synaptic signalling. Together, these findings suggest that cortical gyrification abnormalities in amyotrophic lateral sclerosis are closely linked to white matter degeneration, functional impairment and genetic vulnerability, thereby offering an integrative window into the multiscale pathology of amyotrophic lateral sclerosis.  \n1 The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu 610054, P. R. China  \n2 School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China  \n3 Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R. China  \n4 Xiangya Hospital, Central South University, Jiangxi (National Regional Center for Neurological Diseases), Nanchang, Jiangxi 330038, P. R. China  \n5 Department of Radiology, Xiangya Hospital, Central South University, Changsha , Hunan 410008, China  \n6 School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin 541004, China  \n7 College of Health Solutions, Arizona State University, Phoenix, AZ 85004, USA  \n8 Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases, Changsha, Hunan 410008, P. R. China  \n9 National Clinical Research Center for Geriatric Diseases, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China  \n10 Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Ch","cbCaimCxmEiubR9d","https://ap.wps.com/l/cbCaimCxmEiubR9d","pdf",1163830,13,"English","# Study design and participants\n## Imaging findings on gyrification and white matter\n## Associations with motor and cognitive measures\n## Mediation analysis and functional disability\n## Transcriptomic integration with gene expression\n## Overall mechanistic interpretation","[{\"question\":\"What imaging methods were used to study gyrification in ALS?\",\"answer\":\"The study used structural and diffusion MRI to measure cortical gyrification and white-matter microstructure in ALS patients and matched controls.\"},{\"question\":\"Which brain regions showed altered local gyrification index in ALS patients?\",\"answer\":\"Patients had a significant reduction in local gyrification index in bilateral precentral and postcentral gyri, left middle frontal gyrus, and left superior parietal lobule.\"},{\"question\":\"How did fractional anisotropy relate gyrification to functional disability?\",\"answer\":\"Mediation analysis indicated that fractional anisotropy partially accounted for the relationship between local gyrification index and functional disability, implicating disrupted white-matter pathways in clinical impact.\"}]","Microstructure and gene expression influence gyrification in amyotrophic lateral sclerosis | PDF",1790754555,33]