[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-367460-105":59,"doc-detail-367460-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","micrornas-as-biomarkers-of-breast-cancer","microRNAs as Biomarkers of Breast Cancer","","Breast cancer remains the most common malignancy in women, making early detection crucial for effective therapy and favorable outcomes. MicroRNAs (miRNAs), small single-stranded regulatory RNAs, show special relevance in cancer initiation and development by controlling post-transcriptional oncogene expression. Their high stability due to resistance to RNases enables reliable detection in diverse biological fluids, supporting serum miRNA signatures. The review analyzes how miRNAs may aid early diagnosis, predict disease course, and evaluate treatment effectiveness.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/micrornas-as-biomarkers-of-breast-cancer/367460/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/micrornas-as-biomarkers-of-breast-cancer/367460.png","ImageObject",300,407,{"name":92,"@type":93},"Alex Sinclair","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is early breast cancer detection important?","Question",{"text":112,"@type":113},"Early detection is essential for effective treatment and a favorable prognosis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What role do microRNAs (miRNAs) play in breast cancer?",{"text":117,"@type":113},"miRNAs regulate post-transcriptional expression of oncogenes and are involved in the initiation and development of breast cancer, with dysregulation across normal, precancerous, and cancerous stages.",{"name":119,"@type":110,"acceptedAnswer":120},"Why can microRNAs be detected in biological fluids?",{"text":121,"@type":113},"MicroRNAs are characterized by high stability due to RNase resistance, which protects them from degradation and supports their measurement in various fluids.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},367460,1790538591,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1099523882182,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Review  \nmicroRNAs as Biomarkers of Breast Cancer  \nWojciech Jelski 1,*, Sylwia Okrasinska 2 and Barbara Mroczko 1,3  \nAcademic Editor: Nam Deuk Kim  \nReceived: 9 April 2025  \nRevised: 28 April 2025  \nAccepted: 1 May 2025  \nPublished: 6 May 2025  \nCitation: Jelski, W.; Okrasinska, S.; Mroczko, B. microRNAs as Biomarkers of Breast Cancer. Int. J. Mol. Sci. 2025, 26, 4395. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)ijms26094395  \nCopyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://creativecommons.org/](https://creativecommons.org/)[ ](https://creativecommons.org/)[licenses/by/4.0/](licenses/by/4.0/)) .  \n1 Department of Biochemical Diagnostics, Medical University, Waszyngtona 15 A, 15-269 Bialystok, Poland; [barbara.mroczko@umb.edu.pl](barbara.mroczko@umb.edu.pl)  \n2 Department of Biochemical Diagnostics, University Hospital, Waszyngtona 15 A, 15-269 Bialystok, Poland; [sylwia.okrasinska@uskwb.pl](sylwia.okrasinska@uskwb.pl)  \n3 Department of Neurodegeneration Diagnostics, Medical University, Waszyngtona 15 A, 15-269 Bialystok, Poland  \n* [Correspondence: wojciech.jelski@umb.edu.pl](Correspondence: wojciech.jelski@umb.edu.pl); Tel.: +48-85-746-8587; Fax: +48-85-746-8585  \nAbstract: Breast cancer (BC) is the most common type of cancer found in women. Detection of this cancer at an early stage is essential for effective treatment and a favorable prognosis. Potential early breast cancer biomarkers useful for diagnosing these tumors are microRNAs. These are small single-stranded RNA chains that can regulate the post-transcriptional expression of many different oncogenes. Cancer cells contain miRNAs that play a special role in the etiology of cancer development. The role of microRNAs in the initiation and development of breast cancer gives us great hope for the creation of molecular tools for early cancer detection. MicroRNAs are characterized by a high stability due to RNase, which protects them from degradation and enables their detection in various biological fluids. Researchers have described multiple serum microRNA signatures useful for detecting breast cancer. This review discusses the importance and potential usefulness of microRNAsin detecting breast cancer at an early stage, predicting the course of the disease, and assessing the effectiveness of treatment.  \nKeywords: microRNAs; breast cancer  \n1. Introduction  \nBreast cancer (BC) is the most common malignancy affecting women, the leading cause of cancer death, and the leading cause of all-cause death in women aged 40–55 years. As a result, it remains a serious global health problem worldwide. Although significant progress has been made in its diagnosis and treatment, the heterogeneity of breast tumorsand their varied responses to therapy necessitate a personalized approach to prognosis and treatment selection [1,2] . Breast cancer is a complex disease characterized by excessive cell growth and proliferation. Its etiology is multifactorial, involving both environmental and genetic factors, which results in different molecular subtypes with different clinical courses. With the use of mammography, more and more non-malignant lesions are detected, such as ductal carcinoma in situ, atypical ductal hyperplasia, lobular carcinoma in situ, and atypical lobular hyperplasia. These lesions are one of the most important risk factors for progression to invasive carcinogenesis [3,4] . Detecting cancer lesions at the earliest possible stage and assessing their prognosis are important for increasing the effectiveness of treatment for women with breast cancer. However, mammography is not the best early detection tool due to its limited sensitivity and specificity [5,6] . In recent decades, many new tumor markers have been described which take into account histological variability, tumor size, a","cbCaipF8oHB2C1Mh","https://ap.wps.com/l/cbCaipF8oHB2C1Mh","pdf",598522,17,"English","# Abstract\n# Keywords\n# 1. Introduction","[{\"question\":\"Why is early breast cancer detection important?\",\"answer\":\"Early detection is essential for effective treatment and a favorable prognosis.\"},{\"question\":\"What role do microRNAs (miRNAs) play in breast cancer?\",\"answer\":\"miRNAs regulate post-transcriptional expression of oncogenes and are involved in the initiation and development of breast cancer, with dysregulation across normal, precancerous, and cancerous stages.\"},{\"question\":\"Why can microRNAs be detected in biological fluids?\",\"answer\":\"MicroRNAs are characterized by high stability due to RNase resistance, which protects them from degradation and supports their measurement in various fluids.\"}]","microRNAs as Biomarkers of Breast Cancer | PDF",1790170866,43]