[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-336835-105":59,"doc-detail-336835-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","micrornas-as-biomarkers-of-brain-tumor-review","MicroRNAs as Biomarkers of Brain Tumor - Review","","Brain tumors are highly lethal cancers that are often hard to diagnose during early development, creating an urgent need for low-cost, highly sensitive biomarker testing. MicroRNAs are small non-coding RNAs whose expression in multiple body fluids correlates strongly with cancer status. Evidence from studies on cerebrospinal fluid and blood indicates that microRNAs may enable early brain-tumor detection, support timely therapy, and improve survival prospects, motivating their diagnostic use.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/micrornas-as-biomarkers-of-brain-tumor-review/336835/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/micrornas-as-biomarkers-of-brain-tumor-review/336835.png","ImageObject",300,407,{"name":92,"@type":93},"Rowan","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are brain tumors difficult to diagnose early?","Question",{"text":112,"@type":113},"Brain tumors are often lethal and challenging to detect in the early stages, which motivates development of sensitive diagnostic approaches.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do microRNAs relate to cancer diagnosis?",{"text":117,"@type":113},"MicroRNA expression changes in body fluids correlate with cancer, and studies show shifts in cerebrospinal fluid and blood from patients with brain tumors.",{"name":119,"@type":110,"acceptedAnswer":120},"What biological role do microRNAs play?",{"text":121,"@type":113},"MicroRNAs are small non-coding RNAs involved in post-transcriptional regulation, including degradation or blocking of target RNAs via mechanisms involving the RNA-induced silencing complex.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},336835,1790101682,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},1099514067415,"https://ap-avatar.wpscdn.com/avatar/100002539d78ffe74a7?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779092875211072502","Cancer Management and Research  \nOpen Access Full Text Article REVIEW  \nMicroRNAs as Biomarkers of Brain Tumor  \nWojciech Jelski 1 , Barbara Mroczko 1 , 2  \n1Department of Biochemical Diagnostics, Medical University, Bialystok, Poland; 2Department of Neurodegeneration Diagnostics, Medical University, Bialystok, Poland  \nCorrespondence: Wojciech Jelski, Department of Biochemical Diagnostics, Medical University, Waszyngtona 15 A, Bialystok, 15-269, Poland, Tel +48 85 746 8587, Fax +48 85 746 8585, [Email wjelski@umb.edu.pl](Email wjelski@umb.edu.pl)  \n\n| Abstract: Brain tumors have been deadly cancers for years, and in most cases they are difficult to diagnose in their early stages. For this reason, researchers need to develop low-cost, sensitive methods for examining cancer biomarkers. Such biomarkers include microRNA. MicroRNA expression in various body fluids shows a high correlation with cancer. A number of studies have demonstrated changes in microRNA expression in cerebrospinal fluid and blood samples from patients with brain tumors. New biomarkers such as microRNAs may help diagnose brain tumors at the very beginning of the disease, enabling early treatment and increasing the chances of survival. This review describes the diagnostic role of microRNAs and the prospects for their use as biomarkers in patients with brain tumors.\u003Cbr>Keywords: microRNAs, brain tumor |\n| --- |\n| Introduction\u003Cbr>Tumors ofthe central nervous system (CNS) are very malignant tumors in humans, accounting for approximately 1.35% of all malignant tumors and approximately 3% of cancer-related deaths. CNS tumors include both primary tumors originating from the inside CNS, as well as secondary tumors that arise as a result of the spread of metastases. The main types of primary brain tumors (approximately one third of all tumors) are gliomas, and include astrocytomas, glioblastomas, oligodendrogliomas and ependymomas. Secondary brain tumors most often originate from lung, breast and melanoma tumors. Despite progress in therapeutic methods, the prognosis for patients with CNS tumors is poor.1 Detecting a brain tumor at an early stage of development significantly increases the chance of successful treatment. Therefore, it is necessary to develop simple, sensitive, fast, and relatively cheap analytical methods for its detection. In addition to the imaging methods used, biochemical tests involving the examination and quantitative measurement of biomarkers may be useful. Biomarkers are substances that occur physiologically in cells or fluids ofthe human body, and their quantitative abnormalities occur in patients with cancer or pre-cancer. In recent years, research has focused on microRNA as a biomarker for brain tumors. The interest in microRNAs in cancer diagnostics is the result of their biological nature and high concentrations found in biological fluids; enabling easy detection and preventing sample processing complications.2 MicroRNAs are a class of small non-coding RNAs (\u003C25 bp) that are involved in the degradation or blocking of target microRNA at the post-transcriptional level. MicroRNA genes are transcribed at an early stage as primary microRNAs (pri-microRNA) . The pri-microRNA is then cleaved into a microRNA precursor (premicroRNA) before being released from the nucleus. After reaching the cytoplasm, the pre-microRNA is cleaved into mature microRNA. To perform their regulatory roles, mature microRNAs attach to the RNA-induced silencing complex, which consists of Argonaute and other proteins.3 MicroRNAs play an important role in the stability and intercellular relationship of both healthy and malignant cells. There are three routes of microRNA secretion: passive release from damaged cells due to apoptosis or necrosis; active release facilitated by extracellular vesicles and active release via an RNA binding protein-dependent pathway (miRNA-Ago2 complex) . MicroRNAs can also be secreted independently of vesicles. Nearly 90% of cell-free microRNAs are","cbCaif1LEId3Vemi","https://ap.wps.com/l/cbCaif1LEId3Vemi","pdf",391321,"English","# Introduction\n## MicroRNAs as biomarker candidates\n## MicroRNA biology and secretion routes","[{\"question\":\"Why are brain tumors difficult to diagnose early?\",\"answer\":\"Brain tumors are often lethal and challenging to detect in the early stages, which motivates development of sensitive diagnostic approaches.\"},{\"question\":\"How do microRNAs relate to cancer diagnosis?\",\"answer\":\"MicroRNA expression changes in body fluids correlate with cancer, and studies show shifts in cerebrospinal fluid and blood from patients with brain tumors.\"},{\"question\":\"What biological role do microRNAs play?\",\"answer\":\"MicroRNAs are small non-coding RNAs involved in post-transcriptional regulation, including degradation or blocking of target RNAs via mechanisms involving the RNA-induced silencing complex.\"}]","MicroRNAs as Biomarkers of Brain Tumor - Review | PDF",1790016803,23]