[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-330933-105":59,"doc-detail-330933-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","microrna-mediated-metabolic-regulation-of-immune-cells-in-cancer-an-updated-review","MicroRNA-mediated metabolic regulation of immune cells in cancer - an updated review","","Immunometabolism investigates how immune cells regulate metabolism to sustain performance, making it a key focus in cancer immunology. Advances connect metabolic control with immune-cell activities, while microRNAs (miRNAs) are recognized for post-transcriptional regulation affecting immune function and cancer progression. Evidence indicates miRNAs substantially shape metabolic activity in macrophages, T cells, B cells, and dendritic cells, with disrupted immune metabolism driving cancer progression. Clarifying miRNA effects supports identification of therapeutic targets and improved immunotherapy outcomes.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/microrna-mediated-metabolic-regulation-of-immune-cells-in-cancer-an-updated-review/330933/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/microrna-mediated-metabolic-regulation-of-immune-cells-in-cancer-an-updated-review/330933.png","ImageObject",300,407,{"name":92,"@type":93},"Aria","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-08","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What does immunometabolism study in the context of cancer?","Question",{"text":112,"@type":113},"Immunometabolism studies how immune cells manage their metabolism to maintain optimal function, including how metabolic activity influences immune-cell activation and disease progression.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do microRNAs (miRNAs) relate to immune-cell metabolism?",{"text":117,"@type":113},"miRNAs can post-transcriptionally regulate gene expression and significantly influence the metabolic activity of multiple immune-cell types, particularly in cancer settings.",{"name":119,"@type":110,"acceptedAnswer":120},"Why is understanding miRNA effects on immune metabolism important for cancer therapy?",{"text":121,"@type":113},"Disrupted immune metabolism is linked to cancer progression, so defining miRNA impacts can reveal novel therapeutic targets and support the development of improved cancer immunotherapies.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},330933,1790707573,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},2336464648322,"https://ap-avatar.wpscdn.com/avatar/2200025388227c56fec?_k=1778556882303663488","TYPE Mini Review  \nPUBLISHED 28 June 2024  \nDOI 10.3389/fimmu.2024.1424909  \nOPEN ACCESS  \nEDITED BY  \nAntonio Francesco Campese, Sapienza University of Rome, Italy  \nREVIEWED BY  \nEleni Anastasiadou,  \nSapienza University of Rome, Italy  \n*CORRESPONDENCE Karimeh Haghani  \n [haghani.bio@gmail.com](haghani.bio@gmail.com)[ ](haghani.bio@gmail.com)Salar Bakhtiyari  \n [Salar.bakhtiyari@northwestern.edu](Salar.bakhtiyari@northwestern.edu);  \n [bakhtiyaribio@gmail.com](bakhtiyaribio@gmail.com)  \nRECEIVED 28 April 2024  \nACCEPTED 12 June 2024  \nPUBLISHED 28 June 2024  \nCITATION  \nKhameneh SC, Razi S, Lashanizadegan R, Akbari S, Sayaf M, Haghani K and Bakhtiyari S (2024) MicroRNA-mediated metabolic regulation of immune cells in cancer:  \nan updated review.  \nFront. Immunol. 15:1424909 .  \ndoi: 10.3389/fimmu.2024.1424909  \nCOPYRIGHT  \n© 2024 Khameneh, Razi, Lashanizadegan, Akbari, Sayaf, Haghani and Bakhtiyari. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nMicroRNA-mediated metabolic regulation of immune cells in cancer: an updated review  \nSepideh Chowdary Khameneh 1,2, Sara Razi 1,2,  \nRamin Lashanizadegan 1, Sanaz Akbari3, Masoud Sayaf 4, Karimeh Haghani 5* and Salar Bakhtiyari 5,6*  \n1Vira Ideators of Modern Science, Tehran, Iran, 2Vira Pioneers of Modern Science (VIPOMS), Tehran, Iran, 3 Nourdanesh Institute, Isfahan, Iran, 4 Department of Cellular and Molecular Biology, Faculty of Basic Sciences, Azad University Central Tehran Branch, Tehran, Iran, 5 Department of Clinical Biochemistry, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran, 6 Feinberg Cardiovascular and Renal Research Institute, Northwestern University School of Medicine, Chicago, IL, United States  \nThe study of immunometabolism, which examines how immune cells regulate their metabolism to maintain optimal performance, has become an important area of focus in cancer immunology. Recent advancements in this field have highlighted the intricate connection between metabolism and immune cell function, emphasizing the need for further research. MicroRNAs (miRNAs) have gained attention for their ability to post-transcriptionally regulate gene expression and impact various biological processes, including immune function and cancer progression . While the role of miRNA s in immunometabolism is still being explored, recent studies have demonstrated their significant influence on the metabolic activity of immune cells, such as macrophages, T cells, B cells, and dendritic cells, particularly in cancer contexts. Disrupted immune cell metabolism is a hallmark of cancer progression, and miRNAs have been linked to this process. Understanding the precise impact of miRNAs on immune cell metabolism in cancer is essential for the development of immunotherapeutic approaches. Targeting miRNAs may hold potential for creating groundbreaking cancer immunotherapies to reshape the tumor environment and improve treatment outcomes. In summary, the recognition of miRNAs as key regulators of immune cell metabolism across various cancers offers promising potential for refining cancer immunotherapies . Further investigation into how miRNAs affect immune cell metabolism could identify novel therapeutic targets and lead to the development of innovative cancer immunotherapies.  \nKEYWORDS  \nmicroRNAs (miRNAs), metabolic regulation, immune cells, cancer, immunotherapy  \nFrontiers in Immunology 01 [frontiersin.org](frontiersin.org)  \n1 Introduction  \nImmunometabolism is a field of study that focuses on how immune cells manage their metabolism to sustain optimal function. This involves understa","cbCaicOhbPPJ4TaP","https://ap.wps.com/l/cbCaicOhbPPJ4TaP","pdf",1579768,11,"English","# Introduction\n## Immunometabolism and immune-cell function\n## Cancer-associated metabolic reprogramming and immune consequences","[{\"question\":\"What does immunometabolism study in the context of cancer?\",\"answer\":\"Immunometabolism studies how immune cells manage their metabolism to maintain optimal function, including how metabolic activity influences immune-cell activation and disease progression.\"},{\"question\":\"How do microRNAs (miRNAs) relate to immune-cell metabolism?\",\"answer\":\"miRNAs can post-transcriptionally regulate gene expression and significantly influence the metabolic activity of multiple immune-cell types, particularly in cancer settings.\"},{\"question\":\"Why is understanding miRNA effects on immune metabolism important for cancer therapy?\",\"answer\":\"Disrupted immune metabolism is linked to cancer progression, so defining miRNA impacts can reveal novel therapeutic targets and support the development of improved cancer immunotherapies.\"}]","MicroRNA-mediated metabolic regulation of immune cells in cancer - an updated review | PDF",1789990771,28]