[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331496-105":59,"doc-detail-331496-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","microrna-in-prostate-cancer-from-biogenesis-to-applicative-potential","MicroRNA in prostate cancer: from biogenesis to applicative potential","","Prostate cancer is the most common solid malignant tumor in men and remains highly lethal despite available screening tools such as PSA testing and digital rectal examination, which have limited sensitivity and specificity. While tissue puncture biopsy can provide definitive diagnosis, it yields poor positive predictive value and adds patient burden. This review highlights microRNAs as key post-transcriptional regulators in proliferation, apoptosis, migration, and invasion, discussing diagnostic, prognostic, and therapeutic applications and summarizing major challenges.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/microrna-in-prostate-cancer-from-biogenesis-to-applicative-potential/331496/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/microrna-in-prostate-cancer-from-biogenesis-to-applicative-potential/331496.png","ImageObject",300,407,{"name":92,"@type":93},"Eden","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are current prostate cancer screening methods considered insufficient?","Question",{"text":112,"@type":113},"PSA testing and digital rectal examination enable early detection but their sensitivity and specificity are limited, reducing overall reliability.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What role do microRNAs play in prostate cancer?",{"text":117,"@type":113},"MicroRNAs modulate gene expression post-transcriptionally and participate in processes including cell proliferation, differentiation, apoptosis, migration, and invasion. Dysregulated microRNA expression contributes to tumorigenesis and progression.",{"name":119,"@type":110,"acceptedAnswer":120},"How might microRNAs be used in clinical practice for prostate cancer?",{"text":121,"@type":113},"MicroRNAs are discussed as multifunctional tools for cancer diagnosis, prognostic assessment, and therapy, supported by their regulatory influence on tumor biology.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331496,1790792509,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36,"preview_page_count":4},1374391974468,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Luo and Wen BMC Urology (2024) 24:244 [https://doi.org/10.1186/s12894-024-01634-1](https://doi.org/10.1186/s12894-024-01634-1)  \nBMC Urology  \nREVIEW Open Access  \nMicroRNA in prostate cancer: from biogenesis  to applicative potential  \nXu Luo 1 and Wei Wen2*  \nAbstract  \nProstate cancer is the most common solid malignant tumor in men, characterized by high morbidity and mortality. While current screening tools, such as prostate-specific antigen (PSA) testing and digital rectal examination, are available for early detection of prostate cancer, their sensitivity and specificity are limited. Tissue puncture biopsy, although capable of offering a definitive diagnosis, has poor positive predictive rates and burdens the patient more. Therefore, more reliable molecular diagnostic tools for prostate cancer urgently need to be developed. In recent years, microRNAs (miRNAs) have attracted much attention in prostate cancer research. miRNAs are extensively engaged in biological processes such as cell proliferation, differentiation, apoptosis, migration, and invasion by modulating gene expression post-transcriptionally. Dysregulation of miRNA expression in cancer is considered a critical factor in tumorigenesis and progression. This review first briefly introduces the biogenesis of miRNAs and their functions in cancer, then focuses on tumor-promoting miRNAs and tumor-suppressor miRNAs in prostate cancer. Finally, the potential application of miRNAs as multifunctional tools for cancer diagnosis, prognostic assessment, and therapy is discussed in detail. The concluding section summarizes the major points of the review and the challenges ahead.  \nKeywords Prostate cancer, MicroRNAs, Diagnosis, Prognosis, Therapy, Biomarkers  \nIntroduction  \nProstate cancer is the most common solid malignancy in men and the second most prevalent male cancer worldwide, following lung cancer. It is a leading cause of cancer-related deaths in men as well [1, 2]. While the definitive causes remain unclear, age is an essential risk factor [3]. Prostate cancer is rare in men under 40 but becomes increasingly frequent after 50, with approximately 75% of cases occurring in men aged 65 and over [4–6]. Family history and ethnicity also play critical roles;  \n*Correspondence:  \nWei Wen  \n[weiwenwctfh@hotmail.com](weiwenwctfh@hotmail.com)  \n1Department of Urology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, P. R. China 2Department of Urology, West China Tianfu Hospital, Sichuan University, Chengdu 610213, P. R. China  \nmen with a family history of prostate cancer have an increased risk, and higher incidence, disease progression, and mortality rates are observed among men of African descent compared to other racial groups [7–11].  \nThe development and progression of prostate cancer is often coupled with various genetic and chromosomal abnormalities, with breast cancer susceptibility gene 2 (BRCA2) mutation being one of the most critical genetic risk factors [12]. Mutations in the BRCA2 gene, a pivotal tumor suppressor involved in DNA damage repair, result in a loss of DNA reparative function, increasing genomic instability and ultimately promoting tumor development and progression [13]. Studies have shown that BRCA2 mutations not only raise the risk of prostate cancer but are also associated with greater tumor aggressiveness anda poorer prognosis [12, 14]. In addition, altered chromosome structure is a major pathologic feature of prostate  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to","cbCaikYCi3N2efpy","https://ap.wps.com/l/cbCaikYCi3N2efpy","pdf",1536233,16,"English","# Abstract\n# Keywords\n# Introduction","[{\"question\":\"Why are current prostate cancer screening methods considered insufficient?\",\"answer\":\"PSA testing and digital rectal examination enable early detection but their sensitivity and specificity are limited, reducing overall reliability.\"},{\"question\":\"What role do microRNAs play in prostate cancer?\",\"answer\":\"MicroRNAs modulate gene expression post-transcriptionally and participate in processes including cell proliferation, differentiation, apoptosis, migration, and invasion. Dysregulated microRNA expression contributes to tumorigenesis and progression.\"},{\"question\":\"How might microRNAs be used in clinical practice for prostate cancer?\",\"answer\":\"MicroRNAs are discussed as multifunctional tools for cancer diagnosis, prognostic assessment, and therapy, supported by their regulatory influence on tumor biology.\"}]","MicroRNA in prostate cancer: from biogenesis to applicative potential | PDF",1789993568]