[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-382066-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-382066-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","microrna-375-in-extracellular-vesicles-novel-marker-for-esophageal-cancer-diagnosis","MicroRNA-375 in extracellular vesicles - novel marker for esophageal cancer diagnosis","","The study evaluates whether MicroRNA-375 (miR-375) can serve as a diagnostic biomarker for esophageal cancer by measuring its levels in plasma and extracellular vesicles (EVs). Diagnostic miRNAs were first screened using public databases and then validated with clinical samples. Receiver operating characteristic analyses assessed diagnostic performance, while expression and survival analyses examined top miR-375 target genes using TCGA. Results indicate miR-375 in EVs shows higher diagnostic accuracy than plasma, with EIF4G3 linked to survival.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/microrna-375-in-extracellular-vesicles-novel-marker-for-esophageal-cancer-diagnosis/382066/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/microrna-375-in-extracellular-vesicles-novel-marker-for-esophageal-cancer-diagnosis/382066.png","ImageObject",300,407,{"name":42,"@type":43},"LangkahRina","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-31","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",7,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What 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diagnosis  \nJie Chen, BDa , Zhigang Cai, MDa , Jing Hu, BDa , Lixia Zhou, BDb , Peili Zhang, BDc , Xiaoping Xu, BDa,*   \n\n| Abstract\u003Cbr>Background: MicroRNAs have been confirmed to function as diagnostic biomarkers for esophageal cancer (EC) . This study aimed to investigate the diagnostic potential of miR-375 in the plasma or extracellular vesicles (EVs) of esophageal cancers (ECs) . Methods: miRNAs with diagnostic potential were identified through public database searches and validated through clinical sample testing. The diagnostic value of miR-375 in plasma and EVs was evaluated via receiver operating characteristic analysis and area under the curve. In addition, expression and survival analyses of the top ten target genes of miR-375 were conducted using the cancer genome atlas database.\u003Cbr>Results: MiR-375 was identified as a potential biomarker for ECs by searching the gene expression omnibus database. Results of clinical sample measurements showed that miR-375 in plasma or EVs was significantly different between ECs and controls (P \u003C .01), but did not differ by gender or age. receiver operating characteristic analysis demonstrated that miR-375 in EVs could function as a diagnostic marker for ECs, with a higher area under the curve (0 .852) than that in plasma. The expression and survival analysis of the top ten target genes for miR-375 showed that only EIF4G3 was significantly associated with survival (P \u003C.05) .\u003Cbr>Conclusion: This research shows that miR-375, particularly in EVs, could serve as a biomarker for the diagnosis of ECs. Abbreviations: AFP = α-fetoproteinAUC = area under the curve, CA = carbohydrate antigen, CEA = carcinoembryonic antigen, ECs = esophageal cancers, EVs = extracellular vesicles, GEO = gene expression omnibus, PPI = protein-protein interaction, RT-PCR = real-time quantitative polymerase chain reaction, ROC = receiver operating characteristic curve, TCGA = the cancer genome atlas, TMs = tumor markers. |\n| --- |\n| Keywords: diagnostic biomarker, esophageal cancer, extracellular vesicle, MicroRNA-375 |\n\n1. Introduction  \nEsophageal cancer (EC) is a malignant tumor of the gastrointestinal tract that readily arises in the esophageal mucosa. The overall 5-year survival rate of patients is only 15% to 25% . [1,2] Globally, approximately 300,000 people die each year from EC. [3] Typical EC diagnostic methods include X-ray barium meal angiography, esophagoscopy, and exfoliative cytology.[4] These methods are invasive, costly, and have missed diagnoses, which limits their clinical application.[5,6] Traditional serum tumor markers (TMs) can be used to diagnose and detect dynamic changes in tumors, but they have insufficient sensitivity and predictive value. [7,8] As a result, more sensitive and specific tumor markers are predicted to contribute to the early diagnosis of esophageal cancer (EC) .  \nJC, ZC, and JH contributed equally to this work.  \nThe authors have no funding and conflicts of interest to disclose.  \nAll data generated or analyzed during this study are included in this published article [and its supplementary information files].  \nBlood sample and clinical data collection were approved by the Ethics Review Board of the Naval Medical Center of PLA, Second Military Medical University (Shanghai, China), which number was “AF-HEC-020.” As approved by the Ethics Review Board, oral informed consent for publication was obtained from all participants.  \na Department of Thoracic Surgery, The Naval Medical Center of PLA, Second Military Medical University, Shanghai, China, b Department of Cardiology, The Naval Medical Center of PLA, Second Military Medical University, Shanghai, China, c Department of Critical Medicine, The Naval Medical Center of PLA, Second Military Medical University, Shanghai, China.  \nStudies have shown that abnormal expression of miRNAs is related to the occurrenc","cbCainVscA6pro41","https://ap.wps.com/l/cbCainVscA6pro41","pdf",1269819,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Keywords\n# 1. Introduction","[{\"question\":\"What diagnostic role does miR-375 aim to play in esophageal cancer?\",\"answer\":\"The study investigates miR-375 in plasma and extracellular vesicles as a diagnostic biomarker for esophageal cancer and compares their diagnostic value.\"},{\"question\":\"How were miR-375 candidate biomarkers identified and validated?\",\"answer\":\"Candidate diagnostic miRNAs were identified via public database searches and validated using clinical sample testing, followed by diagnostic performance evaluation with ROC analysis.\"},{\"question\":\"Which sample source performed better for miR-375 as a diagnostic marker?\",\"answer\":\"ROC results showed miR-375 in EVs had a higher area under the curve (0.852) than miR-375 in plasma, supporting EVs as the better diagnostic source.\"}]","MicroRNA-375 in extracellular vesicles - novel marker for esophageal cancer diagnosis | PDF",1790248845]