[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-328930-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-328930-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","microrna-155-and-its-exosomal-form-small-pieces-in-the-gastrointestinal-cancers-puzzle","MicroRNA-155 and its exosomal form: Small pieces in the gastrointestinal cancers puzzle","","Gastrointestinal (GI) cancers drive a large share of global cancer deaths, motivating new diagnostic and therapeutic strategies. MicroRNAs (miRNAs) are short non-coding RNAs that can act as either cancer-promoting or tumor-suppressing regulators, and miR-155 is a key player across multiple GI malignancies such as pancreatic, colon, and gastric cancers. Abnormal miR-155 production correlates with malignancy and increased mortality, making it a promising target. Exosomal miR-155 also supports intercellular communication and shaping of the tumor microenvironment, and review coverage highlights its roles in functions, resistance, diagnosis, and clinical trials.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/microrna-155-and-its-exosomal-form-small-pieces-in-the-gastrointestinal-cancers-puzzle/328930/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/microrna-155-and-its-exosomal-form-small-pieces-in-the-gastrointestinal-cancers-puzzle/328930.png","ImageObject",300,407,{"name":42,"@type":43},"Miles","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-22","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",11,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why is miR-155 considered important in gastrointestinal cancers?","Question",{"text":63,"@type":64},"miR-155 regulates multiple cancer types, with carcinogenic roles reported in pancreatic, colon, and gastric cancers. Abnormal miR-155 production is linked to malignancy and increased mortality.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What role do exosomes and exosomal miR-155 play in GI cancer progression?",{"text":68,"@type":64},"Exosomal miR-155 supports communication between cells and helps establish the tumor microenvironment. Tumor-associated exosomal contents can be transmitted to other cells, promoting tumor advancement.",{"name":70,"@type":61,"acceptedAnswer":71},"How are microRNAs like miR-155 expected to influence gene expression?",{"text":72,"@type":64},"miRNAs bind to the 3’-UTR of their target mRNAs, affecting protein expression by promoting mRNA degradation or inhibiting translation.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},328930,1790091475,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":108,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145},13056703019404,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Cell Biol Toxicol (2024) 40:77  \n[https://doi.org/10.1007/s10565-024-09920-2](https://doi.org/10.1007/s10565-024-09920-2)  \nMicroRNA‑155 and its exosomal form: Small pieces in the gastrointestinal cancers puzzle  \nJinbao Guo · Li Zhong ·  \nMohammad Reza Momeni  \nReceived: 25 April 2024 / Accepted: 4 September 2024 / Published online: 16 September 2024 © The Author(s) 2024  \nAbstract Gastrointestinal (GI) cancers are common cancers that are responsible for a large portion of global cancer fatalities. Due to this, there is a pressing need for innovative strategies to identify and treat GI cancers. MicroRNAs (miRNAs) are short ncRNAs that can be considered either cancer-causing or tumorinhibiting molecules. MicroRNA-155, also known as miR-155, is a vital regulator in various cancer types. This miRNA has a carcinogenic role in a variety of gastrointestinal cancers, including pancreatic, colon, and gastric cancers. Since the abnormal production of miR-155 has been detected in various malignancies and has a correlation with increased mortality, it is a promising target for future therapeutic approaches. Moreover, exosomal miR-155 associated with tumors have significant functions in communicating between cells and establishing the microenvironment for  \nJ. Guo (*)  \nDepartment of Thoracic Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China  \ne-mail: [guojingbao@126.com](guojingbao@126.com)  \n[L. Zhong](L. Zhong)  \nDepartment of Gynecology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China  \nM. R. Momeni (*)  \nSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran [e-mail: momeni.m1209@gmail.com](e-mail: momeni.m1209@gmail.com)  \ncancer in GI cancers. Various types of genetic material, such as specifically miR-155 as well as proteins found in cancer-related exosomes, have the ability tobe transmitted to other cells and have a function in the advancement of tumor. Therefore, it is critical to conduct a review that outlines the diverse functions of miR-155 in gastrointestinal malignancies. As a result, we present a current overview of the role of miR-155 in gastrointestinal cancers. Our research highlighted the role of miR-155 in GI cancers and covered critical issues in GI cancer such as pharmacologic inhibitors of miRNA-155, miRNA-155-assosiated circular RNAs, immune-related cells contain miRNA-155 . Importantly, we discussed miRNA-155 in GI cancer resistance to chemotherapy, diagnosis and clinical trials. Furthermore, the function of miR-155 enclosed inexosomes that are released by cancer cells or tumorassociated macrophages is also covered.  \nKeywords Gastrointestinal cancers · MicroRNA · Exosome · Biomarker  \nIntroduction  \nResearchers projected that in 2019, the United States would see more than 1.7 million newly diagnosed individuals facing cancer and over 607,000 deaths due to the disease (Siegel et al. 2019) . The WHO Classification of Tumors sets the global benchmarks for tumor classification and diagnosis.  \nIt allows for direct comparisons to be made between nations. Diagnosing tumors is not exclusively the pathologists’ domain; nowadays some patients are being treated considering their clinical, liquid biopsy, and radiological results even before tissue samples are obtained. This relevance extends the cataloging to various medical care of individuals with gastrointestinal tumors (Washington et al. 2021) . The GI tract is the location of occurrence of many cancers as the highest incidence of cancers and second highest mortality are related to this system. The gastrointestinal (GI) tract’s cells have a very brief lifespan. The stomach’s epithelial cells, colon, and small intestine that are reproduced of stem cells, are usually replaced within a few days, and are among the tissues, which easily regenerate in the body. These tissues continue to sustain physical, chemical, and biological damage, necessitating this conversion. The ra","cbCaibBXwrYnsdLu","https://ap.wps.com/l/cbCaibBXwrYnsdLu","pdf",1932743,"English","# Abstract\n# Introduction\n# GI cancers\n# MicroRNAs","[{\"question\":\"Why is miR-155 considered important in gastrointestinal cancers?\",\"answer\":\"miR-155 regulates multiple cancer types, with carcinogenic roles reported in pancreatic, colon, and gastric cancers. Abnormal miR-155 production is linked to malignancy and increased mortality.\"},{\"question\":\"What role do exosomes and exosomal miR-155 play in GI cancer progression?\",\"answer\":\"Exosomal miR-155 supports communication between cells and helps establish the tumor microenvironment. Tumor-associated exosomal contents can be transmitted to other cells, promoting tumor advancement.\"},{\"question\":\"How are microRNAs like miR-155 expected to influence gene expression?\",\"answer\":\"miRNAs bind to the 3’-UTR of their target mRNAs, affecting protein expression by promoting mRNA degradation or inhibiting translation.\"}]","MicroRNA-155 and its exosomal form: Small pieces in the gastrointestinal cancers puzzle | PDF",1789981684,101]