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Microplastics have been detected in human blood and multiple organs, and may harm tissues, but their liver-specific mechanisms remain incompletely defined. 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Clinically advanced disease can progress to MASH, which increases the risk of end-stage liver disease.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How are microplastics related to MASLD?",{"text":68,"@type":64},"Microplastics have been detected in human tissues and may exert deleterious effects. 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Numerous studies have demonstrated that the liver is predominantly influenced by environmental and lifestyle risk factors that lead to obesity and diabetes, excessive alcohol consumption, and exposure to environmental pollutants. Microplastics (MPs) are a significant global concern, having been detected in human blood, lungs, kidneys, and liver, and may have deleterious effects on these tissues. Although the effects of MP exposure on the liver have only been partially elucidated, further research is necessary to integrate the direct and extrahepatic effects of MPs on the pathogenesis of MASLD. This review offers a comprehensive analysis of the impact of MPs on hepatic metabolism, including their effects on mitochondrial homeostasis and the endocrine system, with potential implications for the progression of MASLD.  \nKey Words: Metabolic dysfunction-associated steatotic liver disease; Liver; Microplastics; Inflammation; Lipid metabolism  \n©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.  \n WJH  [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 27, 2025  Volume 17  Issue 12   \nRajak S et al. MPs and MASLD  \nCore Tip: Metabolic dysfunction-associated steatotic liver disease (MASLD), is a leading cause of severe liver disease worldwide. Intriguingly, the rise in the incidence of metabolic diseases including MASLD parallels rapid industrialization and environmental pollution worldwide. Microplastics (MPs) are a big global issue and have been found in human blood, lungs, kidneys, and liver. While some effects of MPs on liver health are known, more research is needed to understand how MPs harm the liver and how they relate to lifestyle risks. This article looks at how MPs affect liver metabolism and their role in the progression of MASLD.  \nCitation: Rajak S, Shahi A, Yadav A, Medhe P, Sinha RA. Microplastics in metabolic dysfunction-associated steatotic liver disease: An emerging threat to liver health. World J Hepatol 2025; 17(12): 111198  \nURL: [https://www.wjgnet.com/1948-5182/full","cbCaipwmuoXeWsG4","https://ap.wps.com/l/cbCaipwmuoXeWsG4","pdf",2401715,"English","# Abstract\n# Core Tip\n# Introduction","[{\"question\":\"What is MASLD and why is it clinically important?\",\"answer\":\"MASLD is the predominant cause of liver disease worldwide and is strongly linked to metabolic disorders. Clinically advanced disease can progress to MASH, which increases the risk of end-stage liver disease.\"},{\"question\":\"How are microplastics related to MASLD?\",\"answer\":\"Microplastics have been detected in human tissues and may exert deleterious effects. The review highlights the need to integrate direct and extrahepatic microplastic impacts to clarify MASLD pathogenesis.\"},{\"question\":\"Which biological pathways does the review emphasize for microplastic effects on the liver?\",\"answer\":\"The review focuses on hepatic metabolism, including potential effects on mitochondrial homeostasis and endocrine system regulation, with implications for MASLD progression.\"}]","Microplastics in metabolic dysfunction-associated steatotic liver disease: An emerging threat to liver health | PDF",1790567078,25]