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was the purpose of detecting micronuclei in oral cytologic smears?","Question",{"text":63,"@type":64},"To assess and compare the presence of micronuclei (MN) across healthy controls, high-risk subjects, OPMLs, and malignant oral lesions, and determine whether MN detection adds diagnostic value.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were participants grouped in the study?",{"text":68,"@type":64},"Ninety-two subjects were divided into 46 healthy controls (with and without cancer risk factors), 23 with OPMLs, and 23 with oral malignant lesions.",{"name":70,"@type":61,"acceptedAnswer":71},"What did the study find about diagnostic performance of MN?",{"text":72,"@type":64},"MN diagnostic accuracy was higher in the OPMLs group (95.2%), while sensitivity in the malignant group was lower (52.2%), though malignancy cytological criteria were still markedly detected compared with 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\n[https://doi.org/10.1186/s43046-023-00188-x](https://doi.org/10.1186/s43046-023-00188-x)  \nJournal of the Egyptian National Cancer Institute  \n RESEARCH Open Access  \nMicronuclei detection in oral cytologic smear: does it add diagnostic value?  \nAlaa Elnaggar 1* , Gihane Madkour1, Neveen Tahoun2, Ayman Amin2 and Fat’heya M. Zahran 1  \nAbstract  \nBackground Screening and early diagnosis of oral squamous cell carcinoma (OSCC) are directly associated  \nwith increased survival rate and improved prognosis. Noninvasive diagnostic tools have been implemented  \nin the early detection as toluidine blue staining, optical imaging, and oral cytology. This study aimed to assess and compare the presence of micronuclei (MN) in oral exfoliative cytology of healthy controls, subjects exposed to high-risk factors for oral cancer, subjects with oral potentially malignant lesions (OPMLs), and those with malignant oral lesions.  \nSubjects and methods A total number of 92 subjects were divided into 46 healthy controls with no oral mucosal lesions (23 with no evidence of cancer risk factors and 23 with cancer risk factors), 23 with OPMLs and 23 with oral malignant lesions. All the 92 participants were subjected to cytological sampling for detection of MN. The final diagnosis ofthe oral lesions was confirmed by the histopathological picture and compared to the cytological results. Results The results showed that the diagnostic accuracy of MN was higher in OPMLs group (95 . 2%) . The sensitivity of MN test in malignant group was much lower (52 . 2%); however, all the cytological criteria of malignancy were markedly detected as compared to the OPMLs group.  \nConclusions Conventional oral cytology supported by MN is highly beneficial as adjunctive tool in the screening for early detection of dysplastic oral lesions.  \nKeywords Micronuclei, Exfoliative cytology, Oral potentially malignant lesions, Oral cancer  \nIntroduction  \nOral cancer is the sixth most prevalent cancer worldwide, and about 90% of oral cancer is OSCC. OSCC mostly presents with a highly aggressive course, tendency for lymph node metastasis, and poor prognosis [1]. Based on the world cancer data at 2000, the survival rate is greatly low, about 40%, and it can rise above 80% when it is detected at the early stages (I and II) [2]. A wide range of healthrelated behaviors are associated with oral cancer such as  \n*Correspondence:  \nAlaa Elnaggar [Alaa_hassan@dentistry.cu.edu.eg](Alaa_hassan@dentistry.cu.edu.eg)  \n1 Oral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt  \n2 National Cancer Institute, Cairo University, Cairo, Egypt  \nsmoking, excessive alcoholic drinking, areca nut chewing, HPV infection, and poor oral health [3]. The World Health Organization (WHO) assigned the oral mucosal disorders that have high risk of malignant transformation as OPMLs. Although most of OPMLs are displayed as asymptomatic conditions, the rate of oncogenic abnormalities differs in accordance to patients’ risk factors and lesions’ characteristics as size, consistency, and site [4]. The first step in oral cancer screening is performed through visual and tactile clinical examination. Actually, the main drawback of clinical visualization is subjectivity, so adjunctive tools have been introduced to enhance the visibility of neoplastic lesions as the use of toluidine blue vital staining and autofluorescence imaging. The cytological examination adds benefits to the diagnostic pathway as it has the capability to distinguish between benign and malignant cells in reference to the morphological and the  \n© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the sou","cbCaijeCExNWgqlA","https://ap.wps.com/l/cbCaijeCExNWgqlA","pdf",1635639,"English","# Abstract\n# Background\n# Subjects and methods\n# Results\n# Conclusions\n# Keywords\n# Introduction","[{\"question\":\"What was the purpose of detecting micronuclei in oral cytologic smears?\",\"answer\":\"To assess and compare the presence of micronuclei (MN) across healthy controls, high-risk subjects, OPMLs, and malignant oral lesions, and determine whether MN detection adds diagnostic value.\"},{\"question\":\"How were participants grouped in the study?\",\"answer\":\"Ninety-two subjects were divided into 46 healthy controls (with and without cancer risk factors), 23 with OPMLs, and 23 with oral malignant lesions.\"},{\"question\":\"What did the study find about diagnostic performance of MN?\",\"answer\":\"MN diagnostic accuracy was higher in the OPMLs group (95.2%), while sensitivity in the malignant group was lower (52.2%), though malignancy cytological criteria were still markedly detected compared with OPMLs.\"}]","Micronuclei detection in oral cytologic smear: does it add diagnostic value? | PDF",1790566413,25]