[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-465482-105":59,"doc-detail-465482-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","microbiota-mediated-bile-acid-metabolism-as-a-mechanistic-framework-for-precision-nutrition-in-gastrointestinal-and-metabolic-diseases-academic-narrative-review","Microbiota-Mediated Bile Acid Metabolism as a Mechanistic Framework for Precision Nutrition in Gastrointestinal and Metabolic Diseases - Academic Narrative Review","","Gut microbiota play a central role in shaping bile acid (BA) metabolism through community-specific capacities for deconjugation, dehydroxylation, and other transformation reactions. Distinct microbiome compositional patterns, often described as enterotype-like clusters, map to reproducible functional profiles that generate unique BA metabolic signatures relevant to metabolic and gastrointestinal health. This narrative review synthesizes evidence on microbial composition, BA metabolism, and metabolic dysfunction, linking Bacteroides, Prevotella, and Ruminococcus community types to different secondary BA production and host signaling via FXR and TGR5.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/microbiota-mediated-bile-acid-metabolism-as-a-mechanistic-framework-for-precision-nutrition-in-gastrointestinal-and-metabolic-diseases-academic-narrative-review/465482/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/microbiota-mediated-bile-acid-metabolism-as-a-mechanistic-framework-for-precision-nutrition-in-gastrointestinal-and-metabolic-diseases-academic-narrative-review/465482.png","ImageObject",300,407,{"name":92,"@type":93},"\tCallum ","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-08","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What are the enterotype-like clusters discussed in the review?","Question",{"text":112,"@type":113},"They are compositional patterns of gut microbiota dominated by Bacteroides, Prevotella, or Ruminococcus genera, described as relatively stable configurations associated with reproducible functional profiles.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do different gut microbiome types influence bile acid metabolism?",{"text":117,"@type":113},"Bacteroides-associated communities show higher deconjugation capacity but limited secondary BA production, while Ruminococcus-associated enterotypes have broader secondary BA-producing machinery that affects host signaling through FXR and TGR5.",{"name":119,"@type":110,"acceptedAnswer":120},"What precision-nutrition applications are suggested by the literature synthesis?",{"text":121,"@type":113},"The review highlights microbiome-stratified dietary strategies, targeted probiotics with defined BA-modifying functions, and BA-modulating therapeutic approaches aligned with an individual’s microbial metabolic capacity.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},465482,1790811996,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":41,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},137451211410,"https://ap-avatar.wpscdn.com/avatar/2000bb0a9246f588df?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786362646172706240","Review  \nMicrobiota-Mediated Bile Acid Metabolism as a Mechanistic Framework for Precision Nutrition in Gastrointestinal and Metabolic Diseases  \nSuna Kang 1, Do-Youn Jeong 2, Jeowon Seo 2, James W. Daily 3 and Sunmin Park 1, *  \nAcademic Editors: Sweta Ghosh and Subir Kumar Juin  \nReceived: 2 December 2025  \nRevised: 16 December 2025  \nAccepted: 19 December 2025  \nPublished: 22 December 2025  \nCopyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.  \n1 Department of Food and Nutrition, Obesity/Diabetes Research Center, College of Biohealth Science, Hoseo University, Asan-si 31499, Republic of Korea  \n2 Microbial Institute for Fermentation Industry, Sunchang-gun 56048, Republic of Korea; [jdy2534@korea.kr](jdy2534@korea.kr) (D.-Y.J.)  \n3 R&D, Daily Manufacturing, Rockwell, NC 28138, USA;[jdaily3@yahoo.com](jdaily3@yahoo.com)  \n* Correspondence: [smpark@hoseo.edu](smpark@hoseo.edu); Tel.: +82-41-540-5633; Fax: +82-41-540-5638  \nAbstract  \nGut microbiota play a central role in shaping bile acid (BA) metabolism through communityspecific capacities for deconjugation, dehydroxylation, and other transformation reactions. Distinct microbiome compositional patterns—often referred to as enterotype-like clusters—correspond to reproducible functional profiles that generate unique BA metabolic signatures with relevance for metabolic and gastrointestinal health. This narrative review synthesizes current evidence describing the interplay between microbial composition, BA metabolism, and metabolic dysfunction. A structured literature search was conducted in PubMed, Web of Science, EMBASE, and Scopus using predefined keywords related to bile acids, microbiome composition, metabolic disorders, and enterotypes. Studies were screened for human clinical relevance and mechanistic insights into BA–microbiome interactions. Across the evidence base, Bacteroides-, Prevotella-, and Ruminococcus-associated community types consistently demonstrate different BA transformation capacities that influence secondary BA production and downstream host signaling through FXR and TGR5 . These differences are linked to variation in metabolic dysfunction-associated steatotic liver disease, obesity, type 2 diabetes, inflammatory bowel disease, and colorectal cancer. Host genetic variations in BA synthesis, transport, and signaling further modify these microbiome–BA interactions, contributing to the heterogeneity of dietary intervention responses. Overall, the literature supports a model in which microbiome-derived BA profiles act as metabolic phenotypes that shape host lipid and glucose homeostasis, inflammation, and gut–liver axis integrity. Emerging clinical applications include microbiome-stratified dietary strategies, targeted probiotics with defined BA-modifying functions, and therapeutic approaches that align BA-modulating interventions with an individual’s microbial metabolic capacity. Establishing integrated biomarker platforms combining microbiome clustering with BA profiling will be essential for advancing precision nutrition and personalized management of metabolic and gastrointestinal diseases.  \nKeywords: gut microbiota; enterotypes; bile acids; host genetic polymorphism  \n1. Introduction  \nThe human gut microbiome harbors trillions of microorganisms that profoundly influence host physiology, metabolism, and disease susceptibility [1] . Among the frameworks  \nproposed to interpret this complexity, compositional clustering of gut microbiota—an analytical approach that identifies distinct, reproducible patterns in microbial community structure—has emerged as a powerful model for understanding inter-individual variation in microbiome function [1] . These compositional clusters, commonly referred to as enterotypes, [were first formally described by Arumugam et al. in 2011](were first formally described by Arumugam","cbCailVRo9XlnBkF","https://ap.wps.com/l/cbCailVRo9XlnBkF","pdf",1844217,"English","# Abstract\n# 1. Introduction\n## Enterotypes as compositional clusters\n## Enzymatic signatures and BA transformation\n## Links to metabolic and inflammatory diseases","[{\"question\":\"What are the enterotype-like clusters discussed in the review?\",\"answer\":\"They are compositional patterns of gut microbiota dominated by Bacteroides, Prevotella, or Ruminococcus genera, described as relatively stable configurations associated with reproducible functional profiles.\"},{\"question\":\"How do different gut microbiome types influence bile acid metabolism?\",\"answer\":\"Bacteroides-associated communities show higher deconjugation capacity but limited secondary BA production, while Ruminococcus-associated enterotypes have broader secondary BA-producing machinery that affects host signaling through FXR and TGR5.\"},{\"question\":\"What precision-nutrition applications are suggested by the literature synthesis?\",\"answer\":\"The review highlights microbiome-stratified dietary strategies, targeted probiotics with defined BA-modifying functions, and BA-modulating therapeutic approaches aligned with an individual’s microbial metabolic capacity.\"}]","Microbiota-Mediated Bile Acid Metabolism as a Mechanistic Framework for Precision Nutrition in Gastrointestinal and Metabolic Diseases - Academic Narrative Review | PDF",1790769675,76]