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Despite known contributors to disease development, key mechanisms remain unclear, and evidence suggests intestinal microbiota can modulate carcinogenic processes and immune responses to tumor cells. This study describes culturable microorganisms linked to non-small cell lung cancer collected from rectal swabs and mouthwash, comparing adenocarcinoma and squamous cell carcinoma.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/microbiota-diversity-in-non-small-cell-lung-cancer-gut-and-mouth-cavity-microbiota-diversity-in-non-small-cell-lung-cancer-patients/406409/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/microbiota-diversity-in-non-small-cell-lung-cancer-gut-and-mouth-cavity-microbiota-diversity-in-non-small-cell-lung-cancer-patients/406409.png","ImageObject",300,407,{"name":92,"@type":93},"Fans","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":19},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the focus of the study on microbiota?","Question",{"text":112,"@type":113},"The study characterized culturable microorganisms associated with non-small cell lung cancer using rectal swabs and mouthwash and compared microbiota differences between adenocarcinoma and squamous cell carcinoma.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which NSCLC subtypes were compared?",{"text":117,"@type":113},"The analysis compared adenocarcinoma (ADC) and squamous cell carcinoma (SCC).",{"name":119,"@type":110,"acceptedAnswer":120},"What was observed between ADC and SCC regarding bacterial species?",{"text":121,"@type":113},"A significant difference was reported between the two types in seven bacterial species, with differences including the site of origin.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},406409,1792559768,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":19,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},5909892330395,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","ORIGINAL PAPER  \nPolish Journal of Microbiology 2023, Vol. 72, No 4, 467–475  \n[https://doi.org/10.33073/pjm-2023-044](https://doi.org/10.33073/pjm-2023-044)  \nMicrobiota Diversity in Non‑Small Cell Lung Cancer Gut and Mouth Cavity Microbiota Diversity in Non‑Small Cell Lung Cancer Patients  \nANETA BRISUDOVÁ1, HANA BIELNIKOVÁ-KRYŠTOFOVÁ2, 3, OLDŘICH MOTYKA4, 5, DOMINIKA FRITZOVÁ1, VLADIMÍRA KAŤUCHOVÁ1, NATÁLIE PONIKELSKÁ2, 3, DANIELA SKANDEROVÁ1, VLADISLAV RACLAVSKÝ6, JAROSLAV MICHÁLEK1, MARCEL MITTÁK3, 7, PETRA ŠVECOVÁ8, PETR JAKUBEC8, DENISA ROZSIVALOVÁ8, MAREK SZKORUPA9, JIŘÍ KLEIN10, JOZEF ŠKARDA1, 2, 3*, ZDENĚK KOLÁŘ1 and VALERIA SKOPELIDOU2, 3*  \n1 Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University and University Hospital Olomouc, Olomouc, Czech Republic  \n2 Institute of Molecular and Clinical Pathology and Medical Genetics, University Hospital Ostrava, Ostrava, Czech Republic  \n3 Faculty of Medicine University of Ostrava, Ostrava, Czech Republic  \n4 Faculty of Mining and Geology, VŠB – Technical University of Ostrava, Ostrava, Czech Republic  \n5 Nanotechnology Centre, CEET, VŠB – Technical University of Ostrava, Ostrava, Czech Republic  \n6 Department of Microbiology, Faculty of Medicine and Dentistry, Palacky University  \nand University Hospital Olomouc, Olomouc, Czech Republic  \n7 Department of Surgical Studies, University Hospital Ostrava, Ostrava, Czech Republic  \n8 Department of Respiratory Diseases, Faculty of Medicine and Dentistry, Palacky University  \nand University Hospital Olomouc, Olomouc, Czech Republic  \n9 Department of Surgery I, Faculty of Medicine and Dentistry, Palacky University  \nand University Hospital Olomouc, Olomouc, Czech Republic  \n10 Surgical Clinic, Thomas Baťa Regional Hospital, Czech Republic Submitted 10 August, accepted 27 October 2023, published online 22 December 2023  \nAbs t rac t  \nLung malignancies have a substantial impact on cancer incidence and mortality worldwide. Even though many factors involved in the development of the disease are known, many questions remain unanswered. Previous studies suggest that the intestinal microbiota may have a role in developing malignant diseases. According to some findings, the microbiota has proven to be a key modulator of carcinogenic processes and the immune response against cancer cells, potentially influencing the effectiveness of immunotherapy. In our study, we characterized culturable microorganisms associated with non-small cell lung cancer (NSCLC) that can be recovered from rectal swabs and mouthwash. In addition, we also explored differences in the culturable microbiota with two main types of NSCLC – adenocarcinoma (ADC) and squamous cell carcinoma (SCC) . With 141 patients included in the study (86 ADC and 55 SCC cases), a significant difference was observed between the two types in seven bacterial species (Collinsella, Corynebacterium, Klebsiella, Lactobacillus, Neisseria, Rothia, and Streptococcus), including the site of ori-  \ngin. The relationship between microbial dysbiosis and lung cancer is poorly understood; future research could shed light on the links between gut microbiota and lung cancer development.  \nKeywords: lung cancer, oncogenic mutations, microbiota, non-small cell lung carcinoma  \n* Corresponding authors: J. Škarda, Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University and University Hospital Olomouc, Olomouc, Czech Republic; Institute of Molecular and Clinical Pathology and Medical Genetics, University Hospital Ostrava, Ostrava, Czech Republic; Faculty of Medicine University of Ostrava, Ostrava, Czech Republic;  \ne‑[mail: jozef.skarda@fno.cz](mail: jozef.skarda@fno.cz); +420597372305  \nV. Skopelidou, Institute of Molecular and Clinical Pathology and Medical Genetics, University Hospital Ostrava, Ostrava, Czech Republic;  \nFaculty of Medicine University of Ostrava, Ostrava, Czech Republic; e‑[mail: val.skop@outlook.com](","cbCain4zLx6SRLGP","https://ap.wps.com/l/cbCain4zLx6SRLGP","pdf",276778,"English","# Abstract\n# Introduction","[{\"question\":\"What was the focus of the study on microbiota?\",\"answer\":\"The study characterized culturable microorganisms associated with non-small cell lung cancer using rectal swabs and mouthwash and compared microbiota differences between adenocarcinoma and squamous cell carcinoma.\"},{\"question\":\"Which NSCLC subtypes were compared?\",\"answer\":\"The analysis compared adenocarcinoma (ADC) and squamous cell carcinoma (SCC).\"},{\"question\":\"What was observed between ADC and SCC regarding bacterial species?\",\"answer\":\"A significant difference was reported between the two types in seven bacterial species, with differences including the site of origin.\"}]","Microbiota Diversity in Non-Small Cell Lung Cancer Gut and Mouth Cavity Microbiota Diversity in Non-Small Cell Lung Cancer Patients | PDF",1790565514,23]