[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-326976-105":59,"doc-detail-326976-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","microbiota-changes-the-unseen-players-in-cervical-cancer-progression","Microbiota changes: the unseen players in cervical cancer progression","","Microbiota changes are evaluated as potential markers in cervical cancer progression, focusing on how vaginal microbiota alterations may correlate with disease advancement. A comprehensive review connects findings from studies comparing healthy and cancerous stages, including related conditions such as CIN, SIL, and HPV (+)/(−). Preliminary evidence highlights specific genera as possible biomarkers while recognizing biases and methodological limits, calling for further validation. The review concludes that deeper understanding of the microbial landscape could support diagnosis, prevention, and treatment strategies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/microbiota-changes-the-unseen-players-in-cervical-cancer-progression/326976/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/microbiota-changes-the-unseen-players-in-cervical-cancer-progression/326976.png","ImageObject",300,407,{"name":92,"@type":93},"Anda","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How does this review link vaginal microbiota changes with cervical cancer progression?","Question",{"text":112,"@type":113},"It examines prior studies reporting that shifts in the vaginal microbiota may correlate with cervical cancer advancement, drawing connections across healthy and cancer stages and related abnormalities.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which microbial genera are suggested as potential biomarkers for cervical cancer progression?",{"text":117,"@type":113},"The review highlights Fusobacterium spp., Peptostreptococcus spp., Campylobacter spp., and Haemophilus spp. as potential biomarkers, and discusses other genera that may associate with HPV (+) or HPV (−) states.",{"name":119,"@type":110,"acceptedAnswer":120},"Why does the review call for further research?",{"text":121,"@type":113},"It emphasizes limitations such as potential biases and methodological constraints in existing studies, which limit the certainty of biomarker validation.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},326976,1790186828,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962075006959,"https://ap-avatar.wpscdn.com/avatar/e0002397efbe92a78e?_k=1776741047341049297","TYPE Review  \nPUBLISHED 08 February 2024 DOI 10.3389/fmicb.2024.1352778  \nOPEN ACCESS  \nEDITED BY  \nSvetlana Khaiboullina,  \nUniversity of Nevada, Reno, United States  \nREVIEWED BY  \nIzabela Korona-Glowniak, Medical University of Lublin, Poland António Machado,  \nUniversidad San Francisco de Quito, Ecuador  \n*CORRESPONDENCE  \nW. M. Fong Amaris  \n [wendy.amaris@icb.ufpa.br](wendy.amaris@icb.ufpa.br)[ ](wendy.amaris@icb.ufpa.br)Fabiano Cordeiro Moreira  \n [fcmoreira@ufpa.br](fcmoreira@ufpa.br)[ ](fcmoreira@ufpa.br)RECEIVED 08 December 2023 ACCEPTED 16 January 2024 PUBLISHED 08 February 2024  \nCITATION  \nFong Amaris WM, Assumpção PP, Valadares LJ and Moreira FC (2024)  \nMicrobiota changes: the unseen players in cervical cancer progression.  \nFront. Microbiol. 15:1352778 .  \ndoi: 10.3389/fmicb.2024.1352778  \nCOPYRIGHT  \n© 2024 Fong Amaris, Assumpção, Valadaresand Moreira. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nMicrobiota changes: the unseen players in cervical cancer progression  \nW. M. Fong Amaris 1*, Paulo Pimentel de Assumpção 2, 3,  \nLeonardo Jacomo Valadares 2, 3 and Fabiano Cordeiro Moreira 2*  \n1 Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Brazil, 2 Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, Brazil, 3 Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Belém, Brazil  \nCervical cancer ranks among the most prevalent cancers globally with highrisk human papillomaviruses implicated in nearly 99% of cases. However, hidden players such as changes in the microbiota are now being examined as potential markers in the progression of this disease. Researchers suggest that changes in the vaginal microbiota might correlate with cervical cancer. This review provides a comprehensive look at the microbiota changes linked with the advancement of cervical cancer. It also scrutinizes the databases from past studies on the microbiota during healthy and cancerous stages, drawing connections between prior findings concerning the role of the microbiota in the progression of cervical cancer. Preliminary findings identify Fusobacterium spp., Peptostreptococcus spp., Campylobacter spp., and Haemophilus spp., as potential biomarkers for cervical cancer progression. Alloscardovia spp., Eubacterium spp., and Mycoplasma spp. were identified as potential biomarkers for HPVs (+), while Methylobacterium spp. may be indicative of HPV (−) . However, the study’s limitations, including potential biases and methodological constraints, underscore the need for further research to validate these findingsand delve deeper into the microbiota’s role in HPV development. Despite these limitations, the review provides valuable insights into microbiota trends during cervical cancer progression, offering direction for future research. The review summarizes key findings from previous studies on microbiota during healthy and cancerous stages, as well as other conditions such as CIN, SIL, HPV (+), and HPV (−), indicating a promising area for further investigation. The consistent presence of HPV across all reported cervical abnormalities, along with the identification of distinct bacterial genera between cancerous and control samples, suggests a potential link that merits further exploration. In conclusion, a more profound understanding of the microbial landscape could elucidate the pathogenesis of cervical diseases and inform future strategies for diagnosis, prevention, and treatment.  \nKEYWORDS  \nmicrobiota changes, cervical cancer, progression, biomarkers, vaginal microbiota  \n1 Introducti","cbCaivNbkLJy7BUY","https://ap.wps.com/l/cbCaivNbkLJy7BUY","pdf",1702937,17,"English","# Introduction\n# Microbiota changes and cervical cancer progression\n## Potential biomarkers in different HPV states\n## Research limitations and future directions","[{\"question\":\"How does this review link vaginal microbiota changes with cervical cancer progression?\",\"answer\":\"It examines prior studies reporting that shifts in the vaginal microbiota may correlate with cervical cancer advancement, drawing connections across healthy and cancer stages and related abnormalities.\"},{\"question\":\"Which microbial genera are suggested as potential biomarkers for cervical cancer progression?\",\"answer\":\"The review highlights Fusobacterium spp., Peptostreptococcus spp., Campylobacter spp., and Haemophilus spp. as potential biomarkers, and discusses other genera that may associate with HPV (+) or HPV (−) states.\"},{\"question\":\"Why does the review call for further research?\",\"answer\":\"It emphasizes limitations such as potential biases and methodological constraints in existing studies, which limit the certainty of biomarker validation.\"}]","Microbiota changes: the unseen players in cervical cancer progression | PDF",1789975896,43]