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Human gut microbes can modulate drug efficacy through metabolites, yet existing resources mainly cover gut microbiome–drug interactions rather than microbial gene sequences tied to chemotherapy outcomes. MiCK (Microbial Chemoresistance Knowledgebase) catalogs curated microbial gene sequences linked to chemoresistance and drug metabolism, supporting web-based sequence search and download.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/mick-a-database-of-gut-microbial-genes-linked-with-chemoresistance-in-cancer-patients-comprehensive-research-database-overview/331659/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/mick-a-database-of-gut-microbial-genes-linked-with-chemoresistance-in-cancer-patients-comprehensive-research-database-overview/331659.png","ImageObject",300,407,{"name":92,"@type":93},"Genevieve","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the purpose of MiCK?","Question",{"text":112,"@type":113},"MiCK is presented as a microbial chemoresistance knowledgebase that catalogs microbial gene sequences associated with chemoresistance and drug metabolism, to support research on understanding and mitigating chemoresistance.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How is MiCK assembled and what does it contain?",{"text":117,"@type":113},"MiCK includes 1.6 million sequences covering 29 gene types linked to chemoresistance and drug metabolism, curated manually from recent literature and sequence databases.",{"name":119,"@type":110,"acceptedAnswer":120},"How can users access MiCK for analysis?",{"text":121,"@type":113},"MiCK provides a user-friendly web interface enabling sequence search and download, designed to support downstream analyses.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331659,1790126036,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},1374391974585,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","MiCK: a database of gut microbial genes linked with chemoresistance in cancer patients  \nMuhammad Shahzaib1 , Muhammad Muaz2 , Muhammad Hasnain Zubair1 ,  \nMasood Ur Rehman Kayani 1,*  \n1 Metagenomics Discovery Lab, School of Interdisciplinary Engineering and Sciences (SINES), National University of Sciences and Technology (NUST), Islamabad 44000, Pakistan  \n2 School of Electrical Engineering and Computer Science (SEECS), National University of Sciences and Technology (NUST), Islamabad 44000, Pakistan  \n* Corresponding author. Metagenomics Discovery Lab, School of Interdisciplinary Engineering and Sciences (SINES), National University of Sciences and Technology (NUST), Islamabad 44000, [Pakistan. E-mail:](Pakistan. E-mail: m.kayani@sines.nust.edu.pk)[ m.kayani@sines.nust.edu.pk](Pakistan. E-mail: m.kayani@sines.nust.edu.pk)  \nCitation details: Shahzaib, M., Muaz, M., Zubair, M. et al. MiCK: a database of gut microbial genes linked with chemoresistance in cancer patients.  \nDatabase (2024) Vol. 2024: article ID baae124; DOI: [https://doi.org/10.1093/database/baae124](https://doi.org/10.1093/database/baae124)  \nAbstract  \nCancer remains a global health challenge, with significant morbidity and mortality rates. In 2020, cancer caused nearly 10 million deaths, making it the second leading cause of death worldwide. The emergence of chemoresistance has become a major hurdle in successfully treating cancer patients. Recently, human gut microbes have been recognized for their role in modulating drug efficacy through their metabolites, ultimately leading to chemoresistance. The currently available databases are limited to knowledge regarding the interactions between gut microbiome and drugs. However, a database containing the human gut microbial gene sequences, and their effect on the efficacy of chemotherapy for cancer patients has not yet been developed. To address this challenge, we present the Microbial Chemoresistance Knowledgebase (MiCK), a comprehensive database that catalogs microbial gene sequences associated with chemoresistance. MiCK contains 1.6 million sequences of 29 gene types linked to chemoresistance and drug metabolism, curated manually from recent literature and sequence databases. The database can support downstream analysis as it provides a user-friendly web interface for sequence search and download functionalities. MiCK aims to facilitate the understanding and mitigation of chemoresistance in cancers by serving as a valuable resource for researchers.  \nDatabase URL: [https://microbialchemreskb.com/](https://microbialchemreskb.com/)  \nIntroduction  \nCancer is a significant global health concern, ranking among the leading causes of morbidity and mortality worldwide. According to the WHO, cancer accounted for nearly 10 million deaths in 2020 and was ranked as the second leading cause of global deaths. The GLOBOCAN report highlights that there were approximately 19.3 million new cancer cases and 10 million cancer-related deaths in 2020 [1] . Factors contributing to the incidence of cancer include genetic predisposition, lifestyle factors such as diet, obesity, and alcohol consumption, as well as environmental exposures and infections. Multiple treatment strategies are available for cancer, ranging from surgical interventions to chemotherapy, radiation therapy, immunotherapy, and targeted therapies. The approach to treatment often depends on the type and stage of cancer, as well as the patient’s overall health and preferences [2] .  \nMajor drugs used to treat cancer include 5-Flurouracil (5-FU), Capecitabine, Gemcitabine, Irinotecan, and Oxaliplatin. 5-FU is a commonly used antimetabolite drug for cancer that causes the inhibition of thymidylate synthase, an  \nenzyme essential for DNA synthesis and repair. Capecitabine, a prodrug of 5-FU, is converted to 5-FU in tumor tissues by the enzyme thymidine phosphorylase [3] . Furthermore, it has replaced 5-FU due to its improved pharmacokineticsand tolerability [4] . Gemcita","cbCaim6xpOcwmdQE","https://ap.wps.com/l/cbCaim6xpOcwmdQE","pdf",9727773,"English","# Abstract\n# Introduction\n## Cancer burden and treatment context\n## Major anticancer drugs mentioned\n## Gut microbiome links to chemoresistance\n## Examples of microbial mechanisms","[{\"question\":\"What is the purpose of MiCK?\",\"answer\":\"MiCK is presented as a microbial chemoresistance knowledgebase that catalogs microbial gene sequences associated with chemoresistance and drug metabolism, to support research on understanding and mitigating chemoresistance.\"},{\"question\":\"How is MiCK assembled and what does it contain?\",\"answer\":\"MiCK includes 1.6 million sequences covering 29 gene types linked to chemoresistance and drug metabolism, curated manually from recent literature and sequence databases.\"},{\"question\":\"How can users access MiCK for analysis?\",\"answer\":\"MiCK provides a user-friendly web interface enabling sequence search and download, designed to support downstream analyses.\"}]","MiCK: a database of gut microbial genes linked with chemoresistance in cancer patients - Comprehensive research database overview | PDF",1789994486,18]