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It explains why imaging techniques moved from diagnosis into basic research, enabling noninvasive observation of living model systems. Authors were selected for research impact and for the ability to present methods clearly, reproducibly, and adaptably, supported by graphics, comparisons, and practical troubleshooting.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/methods-in-enzymology-preface/326600/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/methods-in-enzymology-preface/326600.png","ImageObject",300,407,{"name":92,"@type":93},"Maeve","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why did the preface emphasize MRI’s impact on research?","Question",{"text":112,"@type":113},"It highlights that MRI, while recognized for clinical diagnosis and treatment, also made it possible to support basic research through noninvasive observation of living systems.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were authors selected for the volume?",{"text":117,"@type":113},"Authors were chosen based on their research contributions and their ability to describe methodological work in a clear and reproducible way.",{"name":119,"@type":110,"acceptedAnswer":120},"What guidance was given on presenting methodological contributions?",{"text":121,"@type":113},"Contributors were encouraged to use graphics and comparisons to other methods and to include tricks and approaches that help adapt methods to other systems.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},326600,1790184130,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},5909877438554,"https://ap-avatar.wpscdn.com/avatar/5600025385ad2bf12a7?_k=1778553567797529272","METHODS IN ENZYMOLOGY  \nEDITORS-IN-CHIEF  \nJohn N. Abelson Melvin I. Simon  \nDIVISION OF BIOLOGY  \nCALIFORNIA INSTITUTE OF TECHNOLOGY  \nPASADENA, CALIFORNIA  \nFOUNDING EDITORS  \nSidney P. Colowick and Nathan O. Kaplan  \nPreface  \nAs these volumes were being completed, American Paul C. Lauterbur and Briton Sir Peter Mansfield won the 2003 Nobel Prize for medicine for discoveries leading to the development of MRI.  \nThe Washington Post story on October 6, 2003 announced the accolade, noting: ‘‘Magnetic resonance imaging, or MRI, has become a routine method for medical diagnosis and treatment. It is used to examine almost all organs without need for surgery, but is especially valuable for detailed examination of the brain and spinal cord.’’ Unfortunately, the article overlooked the growing usefulness of this technique in basic research.  \nMRI, along with other imaging methods, has made it possible to glance inside the living system. For patients, this may obviate the need for surgery; for researchers, it becomes a noninvasive method that enables the model systems to continue ‘‘doing what they do’’ without being disturbed. The value and potential of these techniques is enormous, and that is why these once clinical methods are finding their way to the laboratory.  \nAuthors have been selected based on research contributions in the area about which they have written and based on their ability to describe their methodological contributions in a clear and reproducible way. They have been encouraged to make use of graphics and comparisons to other methods, and to provide tricks and approaches that make it possible to adapt methods to other systems.  \nThe editor wants to express appreciation to the contributors for providing their contributions in a timely fashion, to the senior editors for guidance, and to the staff at Academic Press for helpful input.  \nP. Michael Conn  \nContributors to Volume 385  \nArticle numbers are in parentheses and following the names of contributors.  \nAffiliations listed are current.  \nDavid L. Alexoff (12), Department of Chemistry, Brookhaven National Laboratory, Upton, New York 11973  \nRobert S. Balaban (15), Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892  \nNicolau Beckmann (14), Novartis Institute for Biomedical Research, Analytical and Imaging Sciences Unit, CH-4002 Basel, Switzerland  \nMarkus Beu (13), Clinic of Nuclear Medicine, University Hospital D¨usseldorf, D¨usseldorf 40225, Germany  \nKevin J. Black (6), Departments of Psychiatry, Neurology, and Radiology, Washington University School of Medicine, St. Louis, Missouri 63110-1093  \nBritton Chance (20), Eldridge Reeves Johnson University, Philadelphia, Pennsylvania 19104  \nDelphine L. Chen (17), Washington University School of Medicine, St. Louis, Missouri 63110  \nPhilippe Choquet (9), Laboratoirede Biomecanique, Centre Hospitalier Universitaire Hautepierre, Strasbourg, France  \nBradley T. Christian (11), Department of Nuclear Medicine and Positron Emission Topography, Kettering Medical Center, Kettering, Ohio 454229  \nStuart Clare (8), Centre for Functional Magnetic Resonance, Department of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Headington, Oxford OX39DU, United Kingdom  \nChristian A. Combs (15), Light Microscopy Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892  \nAndr´E Constantiensco (9), Laboratoirede Biomecanique, Centre Hospitalier Universitaire Hautepierre, Strasbourg, France  \nBruce M. Damon (2), Department of Radiology and Radiological Sciences, Vanderbilt University Institute of Imaging Science, Nashville, Tennessee 37232  \nCarmen S. Dence (16), Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, 63110  \nDoris J. Doudet (10), Department of Medicine/Neurology, Pacific Parkinson Research Center, University of British Columbia, Vancouver, Br","cbCaijBoUumDjXqs","https://ap.wps.com/l/cbCaijBoUumDjXqs","pdf",4690035,437,"English","# Preface\n# Contributors to Volume 385\n## Affiliations and Article Numbers","[{\"question\":\"Why did the preface emphasize MRI’s impact on research?\",\"answer\":\"It highlights that MRI, while recognized for clinical diagnosis and treatment, also made it possible to support basic research through noninvasive observation of living systems.\"},{\"question\":\"How were authors selected for the volume?\",\"answer\":\"Authors were chosen based on their research contributions and their ability to describe methodological work in a clear and reproducible way.\"},{\"question\":\"What guidance was given on presenting methodological contributions?\",\"answer\":\"Contributors were encouraged to use graphics and comparisons to other methods and to include tricks and approaches that help adapt methods to other systems.\"}]","METHODS IN ENZYMOLOGY - Preface | PDF",1789974769,1101]