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This study presents non-hematopoietic metastatic breast neoplasms and evaluates clinicopathological features that help differentiate metastatic from primary tumors. Material and Methods: Cases diagnosed with metastatic non-hematopoietic breast neoplasms in breast resection materials between 2010 and 2023 were analyzed retrospectively using clinicopathological parameters. Results: Fifteen subjects included 11 females (73%) and 4 males (27%), mean age 46.9 years (range 22–63). Carcinoma was most frequent (60%), followed by melanoma (33%) and sarcoma (7%). Among metastatic carcinomas, primaries originated from the lungs (4), gastrointestinal system (2), female genital tract (2), and kidney (1). Sarcoma occurred in one case as leiomyosarcoma from the kidney. Conclusion: Careful histomorphological and immunohistochemical assessment together with detailed clinicoradiological review is critical for appropriate management, treatment planning, and accurate prognostic prediction.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/metastatic-neoplasms-to-the-breast-abstract-and-clinical-pathological-evaluation/381993/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/metastatic-neoplasms-to-the-breast-abstract-and-clinical-pathological-evaluation/381993.png","ImageObject",300,407,{"name":92,"@type":93},"kopisore","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why can metastatic breast neoplasms be mistaken for primary breast tumors?","Question",{"text":112,"@type":113},"When a metastatic mass is present and imaging reveals a solitary tumor focus, insufficient consideration of clinical information can lead to treating the lesion as a primary breast neoplasm.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What types of metastatic non-hematopoietic neoplasms were most common in the study?",{"text":117,"@type":113},"Carcinoma was the most frequent (60%), followed by melanoma (33%) and sarcoma (7%).",{"name":119,"@type":110,"acceptedAnswer":120},"How do the authors recommend establishing the correct clinical course and prognosis?",{"text":121,"@type":113},"Through careful histomorphological and immunohistochemical evaluation, combined with detailed examination of clinicoradiological data to guide management, treatment planning, and prognosis prediction.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},381993,1791095613,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},962090880963,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Metastatic Neoplasms to the Breast  \nMine Özşen, MD1 , Sahsine Tolunay, MD1, Seyit Ali Volkan Polatkan, MD2, Kazım Senol, MD2, and Mustafa Sehsuvar Gokgoz, MD2  \nInternational Journal of Surgical Pathology 2024, Vol. 32(5) 875–883  \n© The Author(s) 2023  \nArticle reuse guidelines: [sagepub.com/journals-permissions](sagepub.com/journals-permissions)[ ](sagepub.com/journals-permissions)[DOI:](DOI: 10.1177/10668969231201415)[ 1](DOI: 10.1177/10668969231201415)[0.](DOI: 10.1177/10668969231201415)[11](DOI: 10.1177/10668969231201415)[77/](DOI: 10.1177/10668969231201415)[1](DOI: 10.1177/10668969231201415)[066896923](DOI: 10.1177/10668969231201415)[1](DOI: 10.1177/10668969231201415)[20](DOI: 10.1177/10668969231201415)[1](DOI: 10.1177/10668969231201415)[4](DOI: 10.1177/10668969231201415)[1](DOI: 10.1177/10668969231201415)[5](DOI: 10.1177/10668969231201415)[ ](DOI: 10.1177/10668969231201415)[journals.sagepub.com/home/ijs](journals.sagepub.com/home/ijs)  \nAbstract  \nObjective: When the clinical presentation is related to the metastatic mass and a radiologically solitary tumor focus is detected, especially in cases where clinical information is not taken into account or is insufficient, if a possible metastatic neoplasia is not kept in mind then it is possible to evaluate the tumor as a primary breast neoplasm. In this study, it is aimed to present our cases of non-hematopoietic metastatic neoplasms and to evaluate the clinicopathological features that may aid in distinguishing metastatic from primary neoplasms. Material and Methods: This study includes cases diagnosed with metastatic non-hematopoietic breast neoplasm in breast resection materials in our center, between the years 2010–2023. All cases were analyzed retrospectively by evaluating clinicopathological features. Results: Of the 15 subjects included in the study, 11 (73%) were female and 4 (27%) were male. The mean age of the patients were 46.9 ranged from 22 to 63 years. The most frequent metastatic malignancy was carcinoma (60%), followed by melanoma (33%) and sarcoma (7%). Of the 9 patients with metastatic carcinoma, the primary tumor originated from the lungs in 4, from gastrointestinal system in 2, female genital tract in 2, and kidney in 1 patient. Sarcoma diagnosis was given in a single patient and the histology was a leiomyosarcoma originating from kidney. Conclusion: A careful histomorphological and immunohistochemical evaluation and a detailed examination of the clinicoradiological data are critical to establish the right course in patient management, treatment plan and to correctly predict the prognosis.  \nKeywords  \nbreast, extramammarian, metastasis, primary tumor  \nIntroduction  \nBreast cancer, constituting 11.6% of all cancers in both genders, is the second most common malignancy worldwide.1 More than 98% of breast malignant neoplasms are primary tumors originating from breast parenchyma. 1.2– 2% are metastatic neoplasms either originating from nonmammary solid organs or the systemic involvement of hematological malignancies. The rate of metastatic breast neoplasia is up to 6 .6% in autopsy series.2  \nIn neoplasms metastasizing to the breast, the primary tumor focus is most frequently detected in the contralateral breast.3 If malignancies originating from breast are excluded, the most frequently metastatic neoplasms are malignant melanoma and lung cancer. Metastases ofsarcomas and carcinomas originating from the female genital tract (ovary, endometrium, cervix), gastrointestinal tract (stomach, colon, rectum), urinary tract (prostate, bladder), head and neck region, and thyroid gland have also been reported. Rhabdomyosarcoma, medulloblastoma, neuroblastoma, and primitive neuroectodermal tumor/ewing sarcoma are tumors that can metastasize to the breast, particularly in children and young adults.4–6  \nDespite their rarity, it is essential to distinguish metastatic breast neoplasms from primary neoplasms to  \nensure correct patient management, avoid unnecessary surgi","cbCaikcIuXWwWwOS","https://ap.wps.com/l/cbCaikcIuXWwWwOS","pdf",8837336,"English","# Abstract\n## Objective\n## Material and Methods\n## Results\n## Conclusion\n# Keywords\n# Introduction\n# Materials and Method\n## Table 1: Clinicopathological features of the cases","[{\"question\":\"Why can metastatic breast neoplasms be mistaken for primary breast tumors?\",\"answer\":\"When a metastatic mass is present and imaging reveals a solitary tumor focus, insufficient consideration of clinical information can lead to treating the lesion as a primary breast neoplasm.\"},{\"question\":\"What types of metastatic non-hematopoietic neoplasms were most common in the study?\",\"answer\":\"Carcinoma was the most frequent (60%), followed by melanoma (33%) and sarcoma (7%).\"},{\"question\":\"How do the authors recommend establishing the correct clinical course and prognosis?\",\"answer\":\"Through careful histomorphological and immunohistochemical evaluation, combined with detailed examination of clinicoradiological data to guide management, treatment planning, and prognosis prediction.\"}]","Metastatic Neoplasms to the Breast - Abstract and Clinical-Pathological Evaluation | PDF",1790248413,23]