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Staging showed pulmonary metastases, and first-line gemcitabine plus cisplatin produced favorable clinical and radiologic stability after three cycles.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/metastatic-bellini-duct-carcinoma-a-case-report-and-literature-review/412006/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/metastatic-bellini-duct-carcinoma-a-case-report-and-literature-review/412006.png","ImageObject",300,407,{"name":42,"@type":43},"Kurz","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-31","2026-09-28",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",11,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why is Bellini collecting duct carcinoma generally associated with poor prognosis?","Question",{"text":63,"@type":64},"It is generally linked to poor prognosis due to delayed diagnosis and limited sensitivity to conventional therapies used for renal cell carcinoma.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What key diagnostic findings confirmed the patient’s disease?",{"text":68,"@type":64},"Histopathology of the nephrectomy specimen showed collecting duct carcinoma features, with positive immunostaining for cytokeratin 7 and epithelial membrane antigen, and negative markers including HER2, PAX8, vimentin, and GATA2.",{"name":70,"@type":61,"acceptedAnswer":71},"What treatment was given for metastatic disease and what was the response?",{"text":72,"@type":64},"First-line chemotherapy with gemcitabine and cisplatin was started, and the patient showed favorable response with clinical and radiologic stability after three cycles.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},412006,1790617930,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":116,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},2336478945635,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Review began 11/04/2025  \nReview ended 11/22/2025  \nPublished 12/02/2025  \n© Copyright 2025  \nEl Maoudda et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CCBY 4.0. , which permits unrestricted use , distribution , and reproduction in any medium , provided the original author and source are credited.  \nDOI: 10.7759/cureus.98287  \nOpen Access Case Report  \nMetastatic Bellini Duct Carcinoma: A Case Report and Literature Review  \nHouda El Maoudda Rhizlane Belbaraka  \n1, Othmane Zouiten 1, Amina Mohtaram 1, Leila Afani 1, Mohamed El Fadli 1, 1  \n1. Department of Medical Oncology, Centre Hospitalo-Universitaire Mohammed VI de Marrakech, Marrakesh, MAR Corresponding author: Houda El Maoudda, [houdaelmouadda@gmail.com](houdaelmouadda@gmail.com)  \nAbstract  \nCollecting duct carcinoma (CDC) of Bellini is a very rare subtype of renal cell carcinoma, generally associated with poor prognosis due to delayed diagnosis and limited sensitivity to conventional therapies used in renal cell carcinoma. We report the case of a 53-year-old female patient who presented with progressive lower back pain and chronic cough. A contrast-enhanced CT urogram revealed a large mass in the left kidney. The patient underwent radical nephrectomy. Histopathological examination confirmed a diagnosis of CDC of the kidney, with positive staining for cytokeratin 7 and epithelial membrane antigen. Staging investigations revealed pulmonary metastatic disease. The patient is receiving first-line chemotherapy with gemcitabine and cisplatin and responded favorably to treatment, showing clinical and radiological stability after three cycles.  \nCategories: Urology, Radiology, Oncology  \nKeywords: bellini collecting tubules, cancer, chemotherapy, metastases, poor prognosis  \nIntroduction  \nBellini duct carcinoma, also known as collecting duct carcinoma (CDC) of the kidney, is a rare and aggressive malignant tumor that accounts for less than 1%[1] of all renal cancers, highlighting the rarity of this histological subtype. Arising from the collecting ducts of the renal excretory system, this carcinoma is characterized by its medullary origin, infiltrative behavior, and generally poor prognosis due to delayed diagnosis and limited sensitivity to conventional therapies used in renal cell carcinoma. We report a clinical case of a patient diagnosed with metastatic Bellini duct carcinoma.  \nCase Presentation  \nWe report the case of a 53-year-old female patient with no significant medical history. The onset of symptoms dates back four months. The clinical history was notable for a chronic dry cough and intermittent lower back pain, without hematuria or other associated signs. These symptoms developed in the context of a worsening general condition. On initial clinical examination, tenderness was noted on palpation over the left lumbar region, with tension in the left flank. The remainder of the physical examination was unremarkable.  \nA contrast-enhanced CT urogram revealed a large tumor mass in the mid-region of the left kidney (Figure 1), measuring 104 × 96 × 111 mm, associated with left latero-aortic lymphadenopathy. A thoracoabdominopelvic CT scan performed for staging revealed multiple bilateral pulmonary nodules and micronodules (Figure 2), diffuse micronodular and flame-like infiltration of the peritoneal fat (Figure 3), and moderate ascites located perihepatically, perisplenically, in both flanks, iliac fossae, and the pelvis (Figure 4) . Additionally, several preaortic (Figure 5) and left latero-aortic lymphadenopathies (Figure 6) were observed, the largest measuring 15 mm in the short axis.  \nHow to cite this article  \nEl Maoudda H , Zouiten O , Mohtaram A, et al. (December 02 , 2025) Metastatic Bellini Duct Carcinoma: A Case Report and Literature Review.  \nCureus 17(12): e98287. DOI 10.7759/cureus.98287  \nFIGURE 1 : Axial CT urogram image demonstrating a large left mid-renal  \nmass  \nFIGURE 2: CT scan image showi","cbCaikGyItLGHBkq","https://ap.wps.com/l/cbCaikGyItLGHBkq","pdf",12611820,"English","# Abstract\n# Introduction\n# Case Presentation\n## Imaging and staging findings\n## Histopathology and immunohistochemistry\n# How to cite this article","[{\"question\":\"Why is Bellini collecting duct carcinoma generally associated with poor prognosis?\",\"answer\":\"It is generally linked to poor prognosis due to delayed diagnosis and limited sensitivity to conventional therapies used for renal cell carcinoma.\"},{\"question\":\"What key diagnostic findings confirmed the patient’s disease?\",\"answer\":\"Histopathology of the nephrectomy specimen showed collecting duct carcinoma features, with positive immunostaining for cytokeratin 7 and epithelial membrane antigen, and negative markers including HER2, PAX8, vimentin, and GATA2.\"},{\"question\":\"What treatment was given for metastatic disease and what was the response?\",\"answer\":\"First-line chemotherapy with gemcitabine and cisplatin was started, and the patient showed favorable response with clinical and radiologic stability after three cycles.\"}]","Metastatic Bellini Duct Carcinoma - A Case Report and Literature Review | PDF",1790590280,23]