[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-327102-105":59,"doc-detail-327102-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","metaplastic-breast-cancer-with-squamous-differentiation-beyond-the-recognized-statistics","Metaplastic Breast Cancer with Squamous Differentiation - Beyond the Recognized Statistics","","Metaplastic breast cancer is a rare breast carcinoma subtype, representing less than 1% of breast neoplasms, and was recognized as an independent pathological diagnosis only toward the end of the 20th century. The case report describes a 51-year-old woman with metaplastic carcinoma showing squamous differentiation, presenting with a left breast mass for two months. Diagnostic workup confirmed grade three disease, triple-negative status, and high Ki-67. Management used neoadjuvant chemotherapy followed by surgery guided by tumor response. The article emphasizes late-stage presentation and poor prognosis, supporting early detection and appropriate management.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/metaplastic-breast-cancer-with-squamous-differentiation-beyond-the-recognized-statistics/327102/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/metaplastic-breast-cancer-with-squamous-differentiation-beyond-the-recognized-statistics/327102.png","ImageObject",300,407,{"name":92,"@type":93},"Finn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main focus of this case report?","Question",{"text":112,"@type":113},"The report describes a case of metaplastic breast cancer with squamous differentiation and provides a brief literature review.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How did the patient present clinically and how long had symptoms been present?",{"text":117,"@type":113},"A 51-year-old woman presented with a left breast mass lasting two months, without pain, nipple discharge, or skin changes.",{"name":119,"@type":110,"acceptedAnswer":120},"What treatment approach was selected and why?",{"text":121,"@type":113},"Neoadjuvant chemotherapy was planned first, followed by surgical intervention (breast-conserving surgery or total mastectomy with sentinel lymph node biopsy) based on response to neoadjuvant therapy.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},327102,1790140633,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":81,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":39},34359740700684,"https://ap-avatar.wpscdn.com/avatar/1f400023980c374ae676?_k=1777273430885731487","Metaplastic Breast Cancer with Squamous Differentiation: Beyond the Recognized Statistics  \nCASE REPORT  \ndoi: 10.5455/medarh.2024.78.75-77  \nMED ARCH. 2024; 78(1): 75-77  \nRECEIVED: DEC 16, 2023  \nACCEPTED: JAN 27, 2024  \n1College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia  \n2Department of Surgery, King Fahd University Hospital, Imam Abdulrahman Bin Faisal University, College of Medicine, Dammam, Saudi Arabia  \n3College of Medicine, King Fahad Hospital in Hofuf, Saudi Arabia  \n4Department of Surgery, King Fahad Specialist Hospital, Dammam, Saudi Arabia  \nCorresponding author: Rania Zaki Fallatah. College of Medicine, Imam Abdulrahman Bin Faisal University,  \nDammam, Saudi Arabia. E-mail: [raniafallatah.z@gmail.com](raniafallatah.z@gmail.com), [https://orcid.org/0000-0002-6603-2254](https://orcid.org/0000-0002-6603-2254)  \n© 2024 Rania Zaki Fallatah, Dhuha N. Boumarah, Ghadeer Hajjaj, Abdullah Ahmed Alkhars, Mohammed AlDuhileb  \nThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ([http://creative](http://creative)[commons.org/licenses/by-nc/4.0/](commons.org/licenses/by-nc/4.0/)) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.  \nMetaplastic Breast Cancer with Squamous Differentiation:  \nBeyond the Recognized Statistics  \nRania Zaki Fallatah1, Dhuha N. Boumarah2, Ghadeer Hajjaj2, Abdullah Ahmed Alkhars3, Mohammed AlDuhileb4  \nABSTRACT  \nBackground: Metaplastic breast cancer is a clinically rare subtype of breast carcinomas, accounting for less than 1% of all breast neoplasms, and was not officially recognized till the end of the 20th century as an independent pathological diagnosis. Objective: In this paper, we report a case of metaplastic breast cancer with squamous differentiation in a 51-year-old female, with a succinct review of the literature. Case Report: The patient presented to our outpatient department with a complaint of left breast mass for 2 months duration with a diagnostic workup found to be grade three metaplastic carcinoma with squamous differentiation. The management decision was to proceed with neoadjuvant chemotherapy, followed by surgical intervention based on the tumor cell response to neoadjuvant therapy. Conclusion: Metaplastic breast cancer represents a rare clinical entity, encountered in a minority of patients. The clinical presentation of metaplastic carcinomasin general is similar to other breast cancers, however, metaplastic breast cancer tend to present in later stages as a rapidly growing mass with poor prognosis. The recognized poor prognosis along with rarity necessities having a high index of suspicion for early detection and appropriate management of metaplastic breast cancer.  \nKeywords: Metaplastic Breast Cancer, Squamous Carcinoma, Breast Neoplasm.  \n1. BACKGROUND  \nMetaplastic breast cancer (MBC) is a clinically rare subtype of breast carcinomas, accounting for less than 1% of all breast neoplasms, and was not officially recognized till the end of the 20th century as an independent pathological diagnosis. The studies on the disease process and its management have been very limited since then due to its rarity and the variety of tumor types included under this diagnosis (1). MBC with squamous differentiation is a subtype of metaplastic breast carcinomas, which is a heterogenous group of rare aggressive form of breast neoplasm encountered in a limited number of patients (1).  \n2. OBJECTIVE  \nHerein, we report a case of metaplastic breast cancer with squamous differentiation in a 51-year-old female, with succinct review of the literature. The present paper was reported in accordance to the SCARE guidelines (2).  \n3. CASE PRESENTATION  \nA 51-year-old female, who is known to have hypertension, presented to our outpatient department with a complaint of left breast mass for 2 months duration. According to the p","cbCainykGUoaLLTM","https://ap.wps.com/l/cbCainykGUoaLLTM","pdf",229030,"English","# Case Report\n## Abstract\n## Background\n## Objective\n## Case Presentation","[{\"question\":\"What is the main focus of this case report?\",\"answer\":\"The report describes a case of metaplastic breast cancer with squamous differentiation and provides a brief literature review.\"},{\"question\":\"How did the patient present clinically and how long had symptoms been present?\",\"answer\":\"A 51-year-old woman presented with a left breast mass lasting two months, without pain, nipple discharge, or skin changes.\"},{\"question\":\"What treatment approach was selected and why?\",\"answer\":\"Neoadjuvant chemotherapy was planned first, followed by surgical intervention (breast-conserving surgery or total mastectomy with sentinel lymph node biopsy) based on response to neoadjuvant therapy.\"}]","Metaplastic Breast Cancer with Squamous Differentiation - Beyond the Recognized Statistics | PDF",1789976324]