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Despite aggressive disease, combined doxorubicin and cyclophosphamide produced complete pathological tumor burn-out and no nodal residual disease, with no recurrence at one year.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/metaplastic-breast-cancer-with-a-unique-presentation-and-complete-response-to-chemotherapy-a-case-report/341180/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/metaplastic-breast-cancer-with-a-unique-presentation-and-complete-response-to-chemotherapy-a-case-report/341180.png","ImageObject",300,407,{"name":42,"@type":43},"Eliana","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-22",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the typical clinical behavior of metaplastic breast carcinoma mentioned in the document?","Question",{"text":63,"@type":64},"Metaplastic breast carcinomas are described as rare, often high-grade, and usually triple-negative, commonly presenting with large primary tumor sizes. They are also associated with a worse prognosis and poorer chemotherapy response than other non-metaplastic triple-negative breast cancers.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Why was the diagnosis considered unusual in the case presentation?",{"text":68,"@type":64},"The patient’s main complaint was a left axillary mass, while there was no clinical nor ultrasonic evidence of a primary breast tumor initially. The subsequent findings supported metastasis to an axillary lymph node from metaplastic breast cancer.",{"name":70,"@type":61,"acceptedAnswer":71},"Which chemotherapy regimen led to the reported complete response, and what were the follow-up results?",{"text":72,"@type":64},"The patient received combined doxorubicin and cyclophosphamide. After six cycles and surgery, pathology showed complete tumor burn-out in the breast with no residual tumor cells and all dissected lymph nodes free of tumor; at one-year follow-up, there were no signs of recurrence.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},341180,1790472902,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":102,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144},4398048949847,"https://ap-avatar.wpscdn.com/avatar/400002536579ef2da7f?_k=1778318612642679267","Nahhat etal. BMC Women's Health (2024) 24:285 BMC Women's Health  \n[https://doi.org/10.1186/s12905-024-03134-8](https://doi.org/10.1186/s12905-024-03134-8)  \nCASE REPORT Open Access  \nMetaplastic breast cancer with a unique presentation and complete response to chemotherapy: a case report  \nFouad Nahhat 1*, Modar Doyya 1, Kareem Zabad 1 and Hazem Ksiri2  \nAbstract  \nBackground Metaplastic breast carcinomas are a rare variant group of breast carcinomas. They are usually highgrade and triple-negative tumors. They often present with large primary tumor sizes. However, the involvement of axillary lymph nodes is infrequent at the time of diagnosis. Metaplastic breast carcinomas are associated with a worse prognosis and a poorer response to chemotherapy in comparison with other non-metaplastic triple-negative breast cancers. Up until this point, there are no specific treatment recommendations for metaplastic breast carcinomas beyond those intended for invasive breast cancer in general.  \nCase presentation A 40-year-old woman complained of a palpable mass in her left axilla. On ultrasonography, the mass was solid, spindle-shaped, hypoechoic with regular borders, and exhibited decreased vascularity. At first, the mass appeared to be of a muscular origin. There was not any clinical nor ultrasonic evidence of a primary breast tumor. On magnetic resonance imaging, the axillary mass was a well-defined with regular borders, measuring  \n24 × 35 mm. Needle biopsy showed a spindle cell tumor with mild to moderate atypia. The subsequent surgical resection revealed a spindle cell neoplasm within a lymph node, favoring a metastatic origin of the tumor. The tumor cells lacked expression of estrogen, progesterone, and HER2 receptors. PET-CT scan indicated pathological uptake in the left breast. Accordingly, the patient was diagnosed with metaplastic breast cancer that had metastasized to the axillary lymph node. She commenced a combined chemotherapy regimen of doxorubicin and cyclophosphamide. After six treatment cycles, she underwent left modified radical mastectomy with axillary lymph node dissection. Pathological examination of the specimens revealed a total burn-out tumor in the breast due to excellent treatment response. There were no residual tumor cells. All dissected lymph nodes were free of tumor. At the one-year follow-up, the patient showed no signs of tumor recurrence.  \nConclusion This report sheds light on a distinctive presentation of metaplastic breast carcinoma, emphasizing the need for vigilance in diagnosing this rare and aggressive breast cancer variant. In addition, the patient’s remarkable response to chemotherapy highlights potential treatment avenues for metaplastic breast cancer.  \nKeywords Metaplastic breast Cancer, Spindle cell carcinoma, Triple-negative breast Cancer, Axillary Lymph Node, Chemotherapy, Doxorubicin, Cyclophosphamide  \n*Correspondence:  \nFouad Nahhat  \n[fouadnahhat@hotmail.com](fouadnahhat@hotmail.com); [nahhat.fouad@damascusuniversity.edu.sy](nahhat.fouad@damascusuniversity.edu.sy)[ ](nahhat.fouad@damascusuniversity.edu.sy)1Faculty of Medicine, Damascus University, Damascus, Syria 2Department of Oncology, Albairouni University Hospital, Damascus, Syria  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly f","cbCaic7lvFTFKe79","https://ap.wps.com/l/cbCaic7lvFTFKe79","pdf",1134867,"English","# Abstract\n## Background\n## Case presentation\n## Conclusion\n# Metaplastic breast carcinoma background\n## Subtype overview and aggressiveness\n## Prognosis and treatment guidance","[{\"question\":\"What is the typical clinical behavior of metaplastic breast carcinoma mentioned in the document?\",\"answer\":\"Metaplastic breast carcinomas are described as rare, often high-grade, and usually triple-negative, commonly presenting with large primary tumor sizes. They are also associated with a worse prognosis and poorer chemotherapy response than other non-metaplastic triple-negative breast cancers.\"},{\"question\":\"Why was the diagnosis considered unusual in the case presentation?\",\"answer\":\"The patient’s main complaint was a left axillary mass, while there was no clinical nor ultrasonic evidence of a primary breast tumor initially. The subsequent findings supported metastasis to an axillary lymph node from metaplastic breast cancer.\"},{\"question\":\"Which chemotherapy regimen led to the reported complete response, and what were the follow-up results?\",\"answer\":\"The patient received combined doxorubicin and cyclophosphamide. After six cycles and surgery, pathology showed complete tumor burn-out in the breast with no residual tumor cells and all dissected lymph nodes free of tumor; at one-year follow-up, there were no signs of recurrence.\"}]","Metaplastic breast cancer with a unique presentation and complete response to chemotherapy - a case report | PDF",1790040734,15]