[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-337008-105":59,"doc-detail-337008-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","metal-phenolic-networks-a-promising-frontier-in-cancer-theranostics-review","Metal-Phenolic Networks: A Promising Frontier in Cancer Theranostics - Review","","The burgeoning field of cancer theranostics has been significantly advanced by the development of Metal-Phenolic Networks (MPNs), integrating the advantages of metals and polyphenols. This review analyzes MPNs and their applications in cancer theranostics using a systematic literature search from 2010 to 2023 across PubMed, Scopus, and Web of Science. It addresses the classification and structures of polyphenolic compounds, mechanisms in cancer treatment, and details roles in drug delivery, photothermal and chemodynamic therapy, imaging, and synergistic strategies, highlighting future directions.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/metal-phenolic-networks-a-promising-frontier-in-cancer-theranostics-review/337008/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/metal-phenolic-networks-a-promising-frontier-in-cancer-theranostics-review/337008.png","ImageObject",300,407,{"name":92,"@type":93},"Quinn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What are Metal-Phenolic Networks (MPNs) and why are they important in cancer theranostics?","Question",{"text":112,"@type":113},"MPNs are supramolecular architectures that integrate the advantages of metals and polyphenols. They are highlighted as a promising frontier for biomedical applications in cancer theranostics.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the literature search conducted in this review?",{"text":117,"@type":113},"A systematic literature search was performed spanning 2010 to 2023 using PubMed, Scopus, and Web of Science.",{"name":119,"@type":110,"acceptedAnswer":120},"Which cancer theranostic applications of MPNs are especially detailed?",{"text":121,"@type":113},"The review emphasizes applications in chemotherapy drug delivery, photothermal therapy, chemodynamic therapy, biomedical imaging, and synergistic therapy.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},337008,1790371460,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962075114765,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","International Journal of Nanomedicine Dovepress  \n Open Access Full Text Article REVIEW  \nMetal-Phenolic Networks: A Promising Frontier in Cancer Theranostics  \nLingjun Li 1 , Jiaoyang Pan2 , Mengwei Huang 3 , Jiamin Sun 3 , Cheng Wang 2 , Hongbin Xu 3  \n1Department of Reproductive Medicine Center, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu Province, People’s Republic of China; 2School of Pharmacy, Changzhou University, Changzhou, Jiangsu Province, People’s Republic of China; 3Obstetrics and Gynecology Department, The Third Affiliated Hospital of Nanjing Medical University (Changzhou No. 2 People’s Hospital), Changzhou, Jiangsu Province, People’s Republic of China  \nCorrespondence: Hongbin Xu, Email [drxu@njmu.edu.cn](drxu@njmu.edu.cn)  \n\n| Abstract: The burgeoning field of cancer theranostics has been significantly advanced by the development of Metal-Phenolic Networks (MPNs), a new class of supramolecular architectures that integrate the advantages of metals and polyphenols. This review focuses on MPNs and their promising applications in cancer theranostics. Through a systematic literature search spanning from 2010 to 2023 in databases including PubMed, Scopus, and Web of Science. The period of search was justified by the rapid evolution of nanomaterials in cancer therapy, with MPNs emerging as a significant player in biomedical applications within the specified timeframe. This review discusses the classification and structure of polyphenolic compounds, as well as their mechanisms of action in cancer treatment. The applications of MPNs in chemotherapy drug delivery, photothermal therapy, chemodynamic therapy, biomedical imaging, and synergistic therapy are especially detailed. The authors emphasize the significance of MPNs in cancer nanomedicine and look forward to their future development directions.\u003Cbr>Keywords: MPN, cancer, theranostics, polyphenolic compounds |\n| --- |\n| Introduction\u003Cbr>Carcinogenesis is a multifaceted condition that encompasses a diverse array of cellular entities, extracellular matrix components, immunological elements, signaling pathways, and physiological processes.1 The fundamental characteristics of malignancy encompass sustained proliferative signals, indefinite replication potential, neovascularization, invasive behavior, metastatic dissemination, defiance of apoptotic cues, escape from growth inhibitors, immunity subversion, and metabolic rewiring.2 Contemporary therapeutic strategies for cancer encompass surgical resection, pharmacological interventions, radiation therapy, and targeted modalities including hormonal, immunological, and genetic approaches; however, these are beset by drawbacks such as elevated likelihood of neoplastic resurgence, irreversible tissue alterations, operative hazards, and unwanted sequelae.3 Moreover, chemotherapeutics, predominantly small molecule agents, frequently grapple with issues like diminished bioavailability, polypharmacological resistance, inadequate specificity, and deleterious collateral effects. Radiation therapy, in addition, may inflict unwarranted injury upon healthy tissues, culminating in grave adverse reactions.4 The differences between the tumor microenvironment (TME) and normal physiological conditions in organs become crucial for the precise targeting of drug delivery platforms. Cancer is viewed as an evolutionary and ecological process,5 involving constant, dynamic, and static interactions between cancer cells and the TME. Due to the genomic instability of cancer cells, they readily develop drug resistance. In contrast, non-tumor cells within the TME have relatively stable genetic characteristics while being susceptible to external factors.6 The TME has a lower pH, reduced permeability, and considerable barrier effects through various mechanisms.7 Components ofthe TME, such as abnormal tumor vasculature, disordered extracellular matrix composition, and interstitia","cbCaijVR1PB8rTMm","https://ap.wps.com/l/cbCaijVR1PB8rTMm","pdf",6216927,17,"English","# Introduction\n# Metal-Phenolic Networks in Cancer Theranostics\n## Classification, structure, and mechanisms\n## Applications: therapy and imaging","[{\"question\":\"What are Metal-Phenolic Networks (MPNs) and why are they important in cancer theranostics?\",\"answer\":\"MPNs are supramolecular architectures that integrate the advantages of metals and polyphenols. They are highlighted as a promising frontier for biomedical applications in cancer theranostics.\"},{\"question\":\"How was the literature search conducted in this review?\",\"answer\":\"A systematic literature search was performed spanning 2010 to 2023 using PubMed, Scopus, and Web of Science.\"},{\"question\":\"Which cancer theranostic applications of MPNs are especially detailed?\",\"answer\":\"The review emphasizes applications in chemotherapy drug delivery, photothermal therapy, chemodynamic therapy, biomedical imaging, and synergistic therapy.\"}]","Metal-Phenolic Networks: A Promising Frontier in Cancer Theranostics - Review | PDF",1790017377,43]