[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-427475-105":59,"doc-detail-427475-en":134},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":127,"head_meta":129,"extra_data":131,"updated_unix":133},105,"en","metabolomics-reveals-exosome-protection-in-aging-mouse-kidneys-via-ferroptosis-alleviation-abstract","Metabolomics Reveals Exosome Protection in Aging Mouse Kidneys via Ferroptosis Alleviation - Abstract","","This study evaluated human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-exos) on renal function in naturally aging mice and investigated the underlying mechanisms. Twenty-four-month-old C57BL/6J mice were assigned to a natural aging group (WT-AC) and an hUCMSC-exos intervention group (WT-AEX). hUCMSC-exos lowered blood urea nitrogen, creatinine, and uric acid, reduced inflammatory infiltration, tubular degeneration, and interstitial fibrosis, and downregulated aging markers. Metabolomics identified 62 differential metabolites, with indoxyl sulfate as a candidate biomarker, and indicated ferroptosis inhibition through altered iron, lipid peroxidation, glutathione redox, and glutathione peroxidase 4.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/metabolomics-reveals-exosome-protection-in-aging-mouse-kidneys-via-ferroptosis-alleviation-abstract/427475/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/metabolomics-reveals-exosome-protection-in-aging-mouse-kidneys-via-ferroptosis-alleviation-abstract/427475.png","ImageObject",300,407,{"name":92,"@type":93},"Miles","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-07","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":19},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main objective of the study on hUCMSC-exos?","Question",{"text":112,"@type":113},"To assess how hUCMSC-exos affect renal function in naturally aging mice and to explore the mechanisms involved.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were the mice grouped and what outcomes were measured?",{"text":117,"@type":113},"C57BL/6J mice were divided into a natural aging group (WT-AC) and an hUCMSC-exos intervention group (WT-AEX). Blood and kidney tissues were analyzed using biochemical markers, histology, and metabolomic profiling.",{"name":119,"@type":110,"acceptedAnswer":120},"Which renal function and tissue changes did hUCMSC-exos produce?",{"text":121,"@type":113},"Compared with natural aging, hUCMSC-exos significantly reduced blood urea nitrogen, creatinine, and uric acid, and reduced inflammatory infiltration, tubular degeneration, and interstitial fibrosis.",{"name":123,"@type":110,"acceptedAnswer":124},"How did the study link exosome treatment to ferroptosis and metabolism?",{"text":125,"@type":113},"hUCMSC-exos inhibited ferroptosis by reducing divalent iron ions and malondialdehyde, increasing the glutathione/oxidized glutathione ratio, and upregulating glutathione peroxidase 4. Metabolomics identified differential metabolites and enriched pathways, supporting a metabolic mechanism.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},427475,1790994430,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":19,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":143,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":144,"faqs":145,"seo_title":146,"seo_description":67,"update_tm":147,"read_time":81},13056703019404,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Innovation in Aging, 2025, Vol. 9, No. S2 749  \nrenal function, reduce inflammation and fibrosis, and mitigate aging-related structural changes in naturally aging mice. The study highlights the protective role of hUCMSC-exos against renal aging through modulation of key metabolic pathways and ferroptosis inhibition, providing potential therapeutic targets foraging-related kidney injury.  \nAbstract citation ID: igaf122.2546  \nMETABOLOMICS REVEALS EXOSOME PROTECTION  \nIN AGING MOUSE KIDNEYS VIA FERROPTOSIS  \nALLEVIATION  \nYanqiu Xing1, and Liu Di2, 1. Qilu hospital of Shandong University, Jinan, Shandong, China (People’s Republic), 2.  \nShandong University, Jinan, Shandong, China (People’s Republic)  \nThis study evaluated the effects of human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-exos) on renal function in naturally aging mice and explored underlying mechanisms. Twenty-four-month-old C57BL/6J mice were divided into a natural aging group (WT-AC, n=10) and an hUCMSC-exos intervention group (WT-AEX, n = 10). Blood and kidney tissues were analyzed for biochemical markers, histological changes, and metabolomic profiles. hUCMSC-exos significantly reduced blood urea nitrogen, creatinine, and uric acid levels compared to the natural aging group (P \u003C 0.01) . Histological examination revealed reduced inflammatory cell infiltration, tubular degeneration, and interstitial fibrosis in the hUCMSC-exos group.  \nTransmission electron microscopy demonstrated mitochondrial shrinkage, cristae rupture, and podocyte foot process effacement in the natural aging group, while the hUCMSC-exos group exhibited restored mitochondrial morphology, including intact cristae and reduced swelling. Aging markers (SA-β-Gal, p16INK4a, and γH2AX) were downregulated in the hUCMSC-exos group.  \nMetabolomics identified 62 differential metabolites, with indoxyl sulfate as a potential biomarker for age-related renal injury.  \nEnriched pathways included glutathione metabolism, glycerolipid metabolism, and aminoacyl-tRNA biosynthesis.  \nhUCMSC-exos inhibited ferroptosis by reducing divalent iron ions and malondialdehyde levels, increasing the glutathione/oxidized glutathione ratio, and upregulating glutathione peroxidase  \n4 expression. These findings suggest that hUCMSC-exos improve","cbCailIuF9yBzXMP","https://ap.wps.com/l/cbCailIuF9yBzXMP","pdf",684822,"English","# Study Objective and Design\n## Animal groups and assessments\n# Biochemical and Histological Effects\n## Blood markers\n## Tissue changes\n# Mechanistic Findings\n## Mitochondrial morphology and aging markers\n# Metabolomics and Pathways\n## Differential metabolites and biomarker\n## Enriched metabolic pathways\n# Ferroptosis Inhibition\n## Iron, lipid peroxidation, and glutathione axis","[{\"question\":\"What was the main objective of the study on hUCMSC-exos?\",\"answer\":\"To assess how hUCMSC-exos affect renal function in naturally aging mice and to explore the mechanisms involved.\"},{\"question\":\"How were the mice grouped and what outcomes were measured?\",\"answer\":\"C57BL/6J mice were divided into a natural aging group (WT-AC) and an hUCMSC-exos intervention group (WT-AEX). Blood and kidney tissues were analyzed using biochemical markers, histology, and metabolomic profiling.\"},{\"question\":\"Which renal function and tissue changes did hUCMSC-exos produce?\",\"answer\":\"Compared with natural aging, hUCMSC-exos significantly reduced blood urea nitrogen, creatinine, and uric acid, and reduced inflammatory infiltration, tubular degeneration, and interstitial fibrosis.\"},{\"question\":\"How did the study link exosome treatment to ferroptosis and metabolism?\",\"answer\":\"hUCMSC-exos inhibited ferroptosis by reducing divalent iron ions and malondialdehyde, increasing the glutathione/oxidized glutathione ratio, and upregulating glutathione peroxidase 4. Metabolomics identified differential metabolites and enriched pathways, supporting a metabolic mechanism.\"}]","Metabolomics Reveals Exosome Protection in Aging Mouse Kidneys via Ferroptosis Alleviation - Abstract | PDF",1790643954]