[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-349858-105":59,"doc-detail-349858-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","metabolism-in-tumour-induced-bone-disease","Metabolism in Tumour-Induced Bone Disease","","Review of recent research on how specific bone-metastatic cancers reprogram metabolism to survive and drive tumour-induced bone disease. Metastatic cells use altered metabolic pathways to adapt to hypoxic bone microenvironments, switching between oxidative phosphorylation and glycolysis, while exploiting neighbouring bone cells for energy and protection from chemotherapy. Targeting these metabolic shifts could improve therapies, reduce tumour burden, and prevent bone destruction, fractures, pain, and increased mortality.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/metabolism-in-tumour-induced-bone-disease/349858/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/metabolism-in-tumour-induced-bone-disease/349858.png","ImageObject",300,407,{"name":92,"@type":93},"Asher","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main focus of this review?","Question",{"text":112,"@type":113},"The review highlights recent studies on metabolic reprogramming in bone metastatic cancers, including breast cancer, prostate cancer, and multiple myeloma.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do tumour cells adapt their metabolism in the bone microenvironment?",{"text":117,"@type":113},"Tumour cells shift metabolic pathways to survive in hypoxic bone niches, moving between oxidative phosphorylation and glycolysis and using neighbouring bone cells for support.",{"name":119,"@type":110,"acceptedAnswer":120},"Why are bone lesions important in tumour-induced bone disease?",{"text":121,"@type":113},"Both osteolytic and osteoblastic lesions disrupt bone homeostasis, weaken bone structure, and contribute to tumour survival and growth, forming a vicious cycle.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},349858,1790167946,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},687197207639,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Current Osteoporosis Reports (2026) 24:8 [https://doi.org/10.1007/s1](https://doi.org/10.1007/s1) 1914-026-00956-3  \nREVIEW  \nMetabolism in Tumour-Induced Bone Disease  \nRenee T. Ormsby1 · Claire M. Edwards1,2  \nReceived: 10 December 2025 / Accepted: 30 January 2026 © The Author(s) 2026  \nAbstract  \nPurpose of Review This review highlights recent studies that investigate the metabolic reprogramming that occurs in specific types of bone metastatic cancers, including different types of breast cancer, prostate cancer and multiple myeloma.  \nRecent Findings Metastatic cancer cells use altered metabolic pathways to adapt in alternate environments. Cancer cells that home towards the bone are able to manipulate their metabolism to survive in the hypoxic microenvironment, shifting between oxidative phosphorylation and glycolysis, whilst also exploiting neighbouring cells within the bone to provide energy and protect against chemotherapies.  \nSummary Targeting the altered metabolic pathways in cancer cells could be used to improve treatments, reduce tumour burden and prevent the destruction of the bone that occurs in tumour-induced bone disease.  \nKeywords Cancer metabolism · Bone metastasis · Multiple myeloma · Prostate cancer · Breast cancer · Bone disease  \nIntroduction  \nMetabolism is now considered a hallmark of cancer [1] . Disseminated cancer cells can adapt by altering their cellular phenotype and activity in order to survive in a different environment from their origins [2] . This adaptation includes altering the metabolic pathways within the cell to obtain enough energy to survive outside of the primary tissue. Metastatic cancer cells modify their metabolism to invade the bone, surviving in low oxygen conditions. Cancer cells then activate a vicious cycle of bone destruction, destabilizing bone homeostasis to promote resorption, causing the formation of osteolytic lesions. This ultimately causes both bone breakdown and absolute invasion by the tumour. Alternatively, cancer cells form osteoblastic lesions where newly formed bone disrupts the normal bone microenvironment, engulfing the bone marrow and expanding into the cortex, compromising the structural integrity of the bone. Both osteolytic and osteoblastic lesions, or a combination  \n􀀍 Claire M. Edwards [claire.edwards@ndorms.ox.ac.uk](claire.edwards@ndorms.ox.ac.uk)  \n1 Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK  \n2 Nuffield Department of Orthopaedics, Rheumatology & Musculoskeletal Sciences, University of Oxford, Oxford, UK  \nof both, lead to tumour-induced bone disease. As a result, the tumour-induced bone disease causes alterations in the bone microstructure, compromising the strength of the bone and leading to fractures, increased pain and increased mortality. The tumour-induced bone disease then feeds back to promote tumour growth and survival, in part by impacting tumour metabolism, and ultimately establishing a vicious cycle of tumour growth and bone disease.  \nThe bone microenvironment is a key component contributing to the shift in metabolism in metastatic cancer cells that home to the bone. Multiple factors influence this, including the decrease in oxygen leading to highly hypoxic areas within the bone, the presence of reactive oxygen species which are key for bone metabolic pathways, and importantly, the multi-cellularity of the bone marrow. Boneresiding cells such as stromal cells, osteoblasts and osteoclasts have been shown to contribute to cancer progression within the bone, providing growth factors and metabolites that allow cancer cells to thrive and survive even after treatment [3] . This cellular crosstalk indicates that both bone cells and cancer cells contribute to bone destruction and tumour growth.  \nThis review will discuss metabolic pathways recently investigated in cancers associated with tumour-induced bone disease, including breast cancer, prostate cancer and multiple myeloma. We will discuss how cancer cells are a","cbCaiasIWL7kGS2S","https://ap.wps.com/l/cbCaiasIWL7kGS2S","pdf",715083,"English","# Abstract\n## Purpose of Review\n## Recent Findings\n## Summary\n# Introduction\n# The Bone Microenvironment and Tumour Cells","[{\"question\":\"What is the main focus of this review?\",\"answer\":\"The review highlights recent studies on metabolic reprogramming in bone metastatic cancers, including breast cancer, prostate cancer, and multiple myeloma.\"},{\"question\":\"How do tumour cells adapt their metabolism in the bone microenvironment?\",\"answer\":\"Tumour cells shift metabolic pathways to survive in hypoxic bone niches, moving between oxidative phosphorylation and glycolysis and using neighbouring bone cells for support.\"},{\"question\":\"Why are bone lesions important in tumour-induced bone disease?\",\"answer\":\"Both osteolytic and osteoblastic lesions disrupt bone homeostasis, weaken bone structure, and contribute to tumour survival and growth, forming a vicious cycle.\"}]","Metabolism in Tumour-Induced Bone Disease | PDF",1790086003,18]