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This study prospectively compared patients with primary fibromyalgia to non-fibromyalgia controls to evaluate traditional cardiovascular risk factors, carotid intima-media thickness, and metabolic syndrome. Metabolic dysfunction–associated steatotic liver disease and hepatic steatosis severity were assessed by sonography. Multivariate regression identified higher central adiposity and more severe hepatic steatosis in fibromyalgia, with symptom severity associated with cardiovascular-related measures.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/metabolic-syndrome-and-metabolic-dysfunction-associated-steatotic-liver-disease-in-fibromyalgia/407909/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/metabolic-syndrome-and-metabolic-dysfunction-associated-steatotic-liver-disease-in-fibromyalgia/407909.png","ImageObject",300,407,{"name":92,"@type":93},"Dipper","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",14,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the study aiming to investigate in fibromyalgia patients?","Question",{"text":113,"@type":114},"The study aimed to investigate cardiovascular risk factors in patients with fibromyalgia, with particular focus on metabolic syndrome, MASLD, and carotid intima-media thickness.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were metabolic dysfunction–associated steatotic liver disease (MASLD) and liver fat severity measured?",{"text":118,"@type":114},"MASLD and the severity of hepatic steatosis were determined by sonography, using Saverymuttu and Hamaguchi scores.",{"name":120,"@type":111,"acceptedAnswer":121},"What key differences were found between fibromyalgia patients and controls?",{"text":122,"@type":114},"Fibromyalgia patients showed a higher proportion of central adiposity and, when present, more severe hepatic steatosis. In female subjects, the proportion of MASLD was also higher in the fibromyalgia group.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},407909,1790672630,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1374404997633,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","ORIGINAL ARTICLE  \nArchives of Rheumatology 2025;40(4):452-458 DOI: 10.5152/ArchRheumatol.2025.25004  \nMetabolic Syndrome and Metabolic Dysfunction-associated Steatotic Liver Disease in Fibromyalgia  \nABSTRACT  \nBackground/Aims: Fibromyalgia (FM) is a chronic disease characterized by widespread pain. An increased cardiovascular risk has been suggested in these patients. The aim was to investigate the cardiovascular risk factors in these patients.  \nMaterials and Methods: Patients with primary FM consecutively were prospectively recruited from a tertiary medical center in Taiwan. As the control group, individuals without FM who had undergone a health checkup examination were recruited. Their traditional cardiovascular risk factors, carotid intima-media thickness (IMT), and the presence of metabolic syndrome were then determined. Metabolic dysfunction–associated steatotic liver disease (MASLD) and the severity of hepatic steatosis (the Saverymuttu and Hamaguchi scores) were both determined by sonography. Multivariate logistic and linear regression were used to compare groups of subjects.  \nResults: A total of 66 FM patients and 116 controls were recruited. Between FM patients and controls, comparable cardiovascular risk factors were found, including carotid IMT and metabolic syndrome. FM patients hada higher proportion of central adiposity when compared with the controls, with an odds ratio of 6.1 (95% CI: 2 .9, 13 .1) . Fibromyalgia patients had amore severe hepatic steatosis, if present, as determined by the Hamaguchi score. In female subjects, FM patients had a higher proportion of MASLD when compared with the controls, with an odds ratio of 2.8 (95% CI: 1.3, 6.1) . The disease severity was associated with left IMT value and lipid blood levels in FM patients.  \nConclusion: Fibromyalgia patients had a higher proportion of central adiposity and more severe hepatic steatosis when compared with the controls. Those patients with more severe FM symptoms likely had a higher cardiovascular risk. Metabolic dysfunction–associated steatotic liver disease merits more attention in FM patients.  \nKeywords: Cardiovascular diseases, carotid intima-media thickness, fibromyalgia, metabolic dysfunction–associated steatotic liver disease, metabolic syndrome  \nIntroduction  \nFibromyalgia (FM) is common, with a 2% prevalence rate in the general population. It is characterized by widespread chronic pain.1 Other bothersome symptoms are sleep disorders, fatigue, and cognitive dysfunction. Dueto the sedentary lifestyle2 and probable inflammatory activity in FM patients,3 an elevated cardiovascular risk is speculated. An increased cardiovascular risk  \nCopyright@Author(s) -[Available online at archivesof rheumatology.com](Available online at archivesof rheumatology.com). Content of this journal is licensed under a Creative Commons Attribution (CC BY) 4.0 International License.  \nChia-Chang Chen1,2,3 Yi-Hsing Chen2,4,5 Der-Yuan Chen5,6,7 Sheng-Shun Yang5,8 Kuo-Tung Tang3,4,5  \n1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan 2Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan  \n3Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan  \n4Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, Taichung, Taiwan  \n5Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan  \n6Rheumatology and Immunology Center, China Medical University Hospital, Taichung, Taiwan 7College of Medicine, China Medical University, Taichung, Taiwan  \n8Kuang Tien General Hospital, Taichung, Taiwan  \nCorresponding author: Kuo-Tung Tang  \n􀀍 [dirac1982@vghtc.gov.tw](dirac1982@vghtc.gov.tw)  \nReceived: May 06, 2025  \nRevision Requested: June 19, 2025 Last Revision Received: September 04, 2025  \nAccepted: September 21, 2025  \nPublication Date: September 03, 2025  \nC","cbCaihEeWwcHxLao","https://ap.wps.com/l/cbCaihEeWwcHxLao","pdf",277362,"English","# Abstract\n## Background/Aims\n## Materials and Methods\n## Results\n## Conclusion\n# Introduction\n# Methods\n## Study Participants\n## Outcomes and Assessments\n## Statistical Analysis\n# Results\n# Discussion\n# Conclusion","[{\"question\":\"What was the study aiming to investigate in fibromyalgia patients?\",\"answer\":\"The study aimed to investigate cardiovascular risk factors in patients with fibromyalgia, with particular focus on metabolic syndrome, MASLD, and carotid intima-media thickness.\"},{\"question\":\"How were metabolic dysfunction–associated steatotic liver disease (MASLD) and liver fat severity measured?\",\"answer\":\"MASLD and the severity of hepatic steatosis were determined by sonography, using Saverymuttu and Hamaguchi scores.\"},{\"question\":\"What key differences were found between fibromyalgia patients and controls?\",\"answer\":\"Fibromyalgia patients showed a higher proportion of central adiposity and, when present, more severe hepatic steatosis. In female subjects, the proportion of MASLD was also higher in the fibromyalgia group.\"}]","Metabolic Syndrome and Metabolic Dysfunction-associated Steatotic Liver Disease in Fibromyalgia | PDF",1790576853,23]