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The review summarizes advances in tumor metabolism, emphasizing the roles of metabolic products and metabolic enzymes in lung cancer initiation and progression. It also discusses progress in therapeutic strategies that target key metabolic pathways, aiming to clarify mechanisms and support development of more effective treatment directions.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/metabolic-reprogramming-in-lung-cancer-and-its-clinical-implication/340717/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/metabolic-reprogramming-in-lung-cancer-and-its-clinical-implication/340717.png","ImageObject",300,407,{"name":92,"@type":93},"Theodora","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What does metabolic reprogramming mean in lung cancer cells?","Question",{"text":113,"@type":114},"It refers to metabolic changes that help lung cancer cells adapt to increased energy demands and biosynthetic requirements for tumor growth.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which metabolic aspects does the review highlight?",{"text":118,"@type":114},"It highlights metabolic products and metabolic enzymes involved in lung cancer occurrence and development, covering glucose, lipid, and amino acid metabolism.",{"name":120,"@type":111,"acceptedAnswer":121},"How is metabolic information used for treatment development?",{"text":122,"@type":114},"The review discusses progress in lung cancer therapies that target relevant metabolic pathways, providing potential directions for improved strategies.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},340717,1790207592,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},687197207919,"https://ap-avatar.wpscdn.com/avatar/a000253d6f5f7c60be?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779446848396160552","TYPE Review  \nPUBLISHED 18 December 2024 DOI 10.3389/fphar.2024.1516650  \nOPEN ACCESS  \nEDITED BY  \nXuelin Zhou,  \nCapital Medical University, China  \nREVIEWED BY  \nWilliam W. Feng,  \nDana–Farber Cancer Institute, United States Xiao Zhang,  \nWashington University in St. Louis, United States Vrushank Bhatt,  \nRutgers, The State University of New Jersey, United States  \nJin-Ming Zhang,  \nUniversity of Texas Health Science Center at Houston, United States  \n*CORRESPONDENCE  \nChen Chen,  \n [18583830676@163.com](18583830676@163.com)[ ](18583830676@163.com)Shenglong Xie,  \n [xieshenglong@163.com](xieshenglong@163.com)  \n†These authors have contributed equally to this work and share first authorship  \nRECEIVED 24 October 2024  \nACCEPTED 28 November 2024  \nPUBLISHED 18 December 2024  \nCITATION  \nHuang Q, Fan L, Gong M, Ren J, Chen C and Xie S (2024) Metabolic reprogramming in lung cancer and its clinical implication.  \nFront. Pharmacol. 15:1516650 .  \ndoi: 10.3389/fphar.2024.1516650  \nCOPYRIGHT  \n© 2024 Huang, Fan, Gong, Ren, Chen and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nMetabolic reprogramming in lung cancer and its clinical implication  \nQingqiu Huang 1†, Lisha Fan 2†, Mingjing Gong 3†, Juntong Ren 4, Chen Chen 5* and Shenglong Xie 1*  \n1Department of Thoracic Surgery, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China, 2Department of Pulmonary and Critical Care Medicine, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China, 3Sichuan Province Revolutionary Disable Armyman Rehab, The First Veterans Hospital Of Sichuan Province, Chengdu, China, 4School of Pharmaceutical Sciences, Guizhou University, Guiyang, China, 5Department of Outpatient, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China  \nLung cancer has posed a significant challenge to global health, and related study has been a hot topic in oncology. This article focuses on metabolic reprogramming of lung cancer cells, a process to adapt to energy demandsand biosynthetic needs, supporting the proliferation and development of tumor cells. In this study, the latest studies on lung cancer tumor metabolism were reviewed, including the impact of metabolic products and metabolic enzymes on the occurrence and development of lung cancer, as well as the progress in the field of lung cancer treatment targeting relevant metabolic pathways. This provides some promising potential directions into exploring lung cancer tumor metabolism and helps researchers to better understand lung cancer.  \nKEYWORDS  \nmetabolic reprogramming, lung cancer, glucose, lipid metabolism, amino acid metabolism  \n1 Introduction  \nIn 2012, 14.1 million new cases of malignant tumors were diagnosed globally and 8.2 million people died from malignant tumors. The most commonly diagnosed types of cancer inlude lung (1.82 million cases), cancer (1.67 million cases), and colorectal (1.36 million cases); cancer (1.6 million deaths), cancer (745,000 deaths), and cancer (723,000 deaths from) were the leading causes of cancer-related deaths (Ferlay et al., 2015) . Lung cancer poses a significant challenge to global health. Approximately 2.1 million people are diagnosed with lung cancer each year, and about 1.8 million people lose their lives as a result (Fr et al., 2017; Bray et al., 2018; Muscat et al., 1997) . The global incidence of cancer continues to rise, despite a decline in the incidence of cancer in men in some Western countries. The d","cbCaioSlqFeTZOzA","https://ap.wps.com/l/cbCaioSlqFeTZOzA","pdf",1591149,14,"English","# Introduction\n## Global burden and clinical landscape of lung cancer\n## Diagnosis, subtypes, and survival outcomes\n## Treatment approaches and need for new strategies\n## Overview of cellular metabolism in oncogenesis","[{\"question\":\"What does metabolic reprogramming mean in lung cancer cells?\",\"answer\":\"It refers to metabolic changes that help lung cancer cells adapt to increased energy demands and biosynthetic requirements for tumor growth.\"},{\"question\":\"Which metabolic aspects does the review highlight?\",\"answer\":\"It highlights metabolic products and metabolic enzymes involved in lung cancer occurrence and development, covering glucose, lipid, and amino acid metabolism.\"},{\"question\":\"How is metabolic information used for treatment development?\",\"answer\":\"The review discusses progress in lung cancer therapies that target relevant metabolic pathways, providing potential directions for improved strategies.\"}]","Metabolic reprogramming in lung cancer and its clinical implication | PDF",1790038424,35]