[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-424440-105":3,"detail-sidebar-cat-0-en-105":77,"doc-detail-424440-en":127},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":70,"head_meta":72,"extra_data":74,"updated_unix":76},105,"en","metabolic-regulation-of-inflammation-in-aging","METABOLIC REGULATION OF INFLAMMATION IN AGING","","Age-related cellular changes impair CD4+ T cell function, with older adults showing elevated mitochondrial complex II (SDH) expression and increased proinflammatory Th17 cytokine production. This study tests whether SDH hyperactivation is required for induction of proinflammatory cytokines and defines the mechanistic link between SDH activity and Th17 cytokine generation. CD4+ T cells from young and older adults were analyzed after pharmacological and genetic SDH modulation to quantify mitochondrial structure, function, metabolites, and cytokines. SDH activation increased succinate oxidation, altered fumarate/succinate balance, stabilized HIF-1α, and enhanced Th17 cytokines, while SDH inhibition reduced cytokines.",{"@graph":14,"@context":69},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/metabolic-regulation-of-inflammation-in-aging/424440/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/metabolic-regulation-of-inflammation-in-aging/424440.png","ImageObject",300,407,{"name":42,"@type":43},"Ben ","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-07","2026-09-28",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",15,{"@type":57,"mainEntity":58},"FAQPage",[59,65],{"name":60,"@type":61,"acceptedAnswer":62},"How were SDH activity levels manipulated in CD4+ T cells?","Question",{"text":63,"@type":64},"SDH was modulated both pharmacologically and genetically, and mitochondrial structure, function, metabolites, and cytokine production were measured.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What happens to proinflammatory cytokines when SDH is inhibited in older adults?",{"text":68,"@type":64},"Genetic and pharmacological inhibition of SDH in CD4+ T cells from older adults decreases proinflammatory cytokine production.","https://schema.org",{"og:url":32,"og:type":71,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":73,"canonical":32},"index,follow",{"doc_id":75,"site_id":7},424440,1790812013,{"code":4,"msg":78,"data":79},"success",[80,84,88,92,97,102,106,111,116,119,123],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":81,"show_sort_weight":82,"slug":83},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Exam",70,"exam",{"id":93,"doc_module":4,"doc_module_name":25,"category_name":94,"show_sort_weight":95,"slug":96},5,"Comic",60,"comic",{"id":98,"doc_module":4,"doc_module_name":25,"category_name":99,"show_sort_weight":100,"slug":101},6,"Technology",50,"technology",{"id":103,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":104,"slug":105},7,40,"healthcare",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},8,"Research & Report",30,"research-report",{"id":112,"doc_module":4,"doc_module_name":25,"category_name":113,"show_sort_weight":114,"slug":115},9,"Religion & Spirituality",20,"religion-spirituality",{"id":114,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":114,"slug":118},"World Cup","world-cup",{"id":120,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":120,"slug":122},10,"Lifestyle","lifestyle",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":93,"slug":126},19,"General","general",{"code":4,"msg":78,"data":128},{"doc_id":75,"user_id":129,"nickname":42,"user_avatar":130,"doc_module":4,"category_id":103,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":131,"file_id":132,"file_url":133,"file_type":134,"file_size":135,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":22,"language":136,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":137,"faqs":138,"seo_title":139,"seo_description":12,"update_tm":140,"read_time":30,"preview_page_count":4},2336478951081,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Innovation in Aging, 2025, Vol. 9, No. S2 1245  \nAbstract citation ID: igaf122.4162  \nMETABOLIC REGULATION OF INFLAMMATION  \nIN AGING  \nMichaella Niceforo1, Gabrielle Chase1, Lydia Gugliuzza1, Ava Lankowski2, and Leena Bharath1, 1. Merrimack college, North Andover, Massachusetts, United States, 2. Merrimack college, Merrimack College, Massachusetts, United States  \nAge-related cellular changes negatively impact the function of CD4+ T cells. Our prior work showed that mitochondrial complex II (Succinate dehydrogenase (SDH)) expression was upregulated in T cells from older (O) adults (60-80 years old) . T cells from O adults also produced higher amounts of cytokines that are generally considered proinflammatory, such as Th17 cytokines, IL-17A/F, IL-21, and Th-17 supportive cytokine IL-6, compared to T cells from young (Y) adults (25-40 years old) . The objective of our study is to evaluate whether hyperactivation of SDH is required for the induction of proinflammatory cytokines and the mechanistic link between SDH and Th17 cytokine production. CD4+ T cells were isolated from lean normoglycemic younger (Y; avg: 31.58 yrs; BMI 21.14 kg/m2) and older (O; avg: 64.81 yrs; BMI 21.95kg/m2) adults. SDH was pharmacologically and genetically modulated, and mitochondrial structure, function, metabolites, and cytokine production were quantified. SDH activation in T cells from O adults induced heightened oxidation of succinate, disrupted the ratio of fumarate to succinate, stabilized HIF-1α, and promoted Th17 cytokines. Genetic and pharmacological inhibition of SDH inT cells from O adults lowered proinflammatory cytokine production, whereas exogenous addition of cell-permeable succinate induced SDH protein in T cells from Y adults, recapitulating the proinflammatory Th17 profile observed in T cells from O adults. These data establish a mechanistic link between SDH and Th17 inflammation.","cbCairQpH481vI35","https://ap.wps.com/l/cbCairQpH481vI35","pdf",1098818,"English","# Abstract\n## Study Objective\n## Methods\n## Key Findings\n## Mechanistic Conclusion","[{\"question\":\"How were SDH activity levels manipulated in CD4+ T cells?\",\"answer\":\"SDH was modulated both pharmacologically and genetically, and mitochondrial structure, function, metabolites, and cytokine production were measured.\"},{\"question\":\"What happens to proinflammatory cytokines when SDH is inhibited in older adults?\",\"answer\":\"Genetic and pharmacological inhibition of SDH in CD4+ T cells from older adults decreases proinflammatory cytokine production.\"}]","METABOLIC REGULATION OF INFLAMMATION IN AGING | PDF",1790634222]