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This hospital-based cohort study assessed whether age, metabolic multimorbidity, and inflammatory–metabolic biomarkers relate to obstruction severity and length of stay among 677 adults undergoing surgery for histologically confirmed colon cancer. Acute presentation was classified as no obstruction, subocclusive syndrome, or frank obstruction. Multivariable logistic/ordinal regression evaluated presentation severity and linear regression evaluated length of stay. Age showed modest independent associations with obstruction severity, while comorbidity count and routine markers such as CRP offered limited discrimination. 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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.  \n1 Doctoral School,“Victor Babes” University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania; flavius.herlo@umft.ro (L.-F.H.); aneta.goia@umft.ro (A.-R.D.); adelina.marinescu@umft.ro (A.R.M.); [talida.cut@umft.ro](talida.cut@umft.ro) (T.G.C.)  \n2 Department of Surgical Semiology,“Victor Babes” University of Medicine and Pharmacy Timisoara,  \n300041 Timisoara, Romania; [octavian.cretu@umft.ro](octavian.cretu@umft.ro) (O.M.C.); [radu.dan@umft.ro](radu.dan@umft.ro) (R.G.D.)  \n3 Department XIII, Discipline of Infectious Diseases,“Victor Babes” University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania  \n4 Surgical Oncology Department, Emergency County Hospital Oradea, 410169 Oradea, Romania  \n5 Department of Clinic Nursing,“Victor Babes” University of Medicine and Pharmacy Timisoara,  \n300041 Timisoara, Romania; [virzob.claudia@umft.ro](virzob.claudia@umft.ro)  \n6 Department of Forensic Medicine, Bioethics, Medical ethics and Medical Law,“Victor Babes” University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania; [raluca.dumache@umft.ro](raluca.dumache@umft.ro)  \n7 Center for Ethics in Human Genetic Identifications,“Victor Babes” University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania  \n* Correspondence: [alexandra.mocanu@umft.ro](alexandra.mocanu@umft.ro) (A.H.); [ddejeu@uoradea.ro](ddejeu@uoradea.ro) (D.D.)† These authors have contributed equally to this work.  \nAbstract  \nBackground/Objectives: Metabolic comorbidities and systemic inflammation are implicated in colon carcinogenesis, yet their relationship with acute obstructive presentation and early in-hospital course remains unclear. This study evaluated whether age, metabolic multimorbidity, and inflammatory–metabolic biomarkers are associated with obstruction severity and length of stay in a surgical colon cancer cohort. Methods: We analyzed 677 consecutive adults undergoing surgery for histologically confirmed colon cancer. Acute presentation was categorized as no obstruction, subocclusive syndrome, or frank obstruction. Predictors included age, comorbidity count (multimorbidity defined as ≥2), diabetes, hypertension, and preoperative biomarkers (C-reactive protein (CRP), lipids, glucose; neutrophil-to-lymphocyte ratio (NLR)/platelet-to-lymphocyte ratio (PLR)/C-reactive protein-to-albumin ratio (CAR)where available) . Multivariable logistic and ordinal regression assessed obstructive presentation; linear regression assessed length of stay. Results: Subocclusion or obstruction occurred in 34.8% of patients. In multivariable logistic regression, age was independently associated with obstructive presentation (odds ratio (OR)  \n1.016 per year; 95% confidence interval (CI) 1.001–1.032), while comorbidity count and CRP were not. In an ordinal model, age increased the odds of more severe presentation (OR 1.018 per year), whereas diabetes was inversely associated (OR 0.573) . Length of stay was independently associated only with presentation severity (β = −0.959 days per category) . Correlations between inflammatory indices and length of stay were negligible. Conclusions: In this hospital-based surgical cohort, age showed a modest association with obstructive presentation, while metabolic multimorbidity and routine","cbCaicLGucy3iXZ0","https://ap.wps.com/l/cbCaicLGucy3iXZ0","pdf",1160602,"English","# Abstract\n## Methods and outcomes\n## Results\n## Conclusions\n# Introduction\n## Epidemiology and global burden\n## Lifestyle and metabolic risk factors\n## Biological pathways of colon carcinogenesis","[{\"question\":\"What was the main aim of this study in colon cancer patients?\",\"answer\":\"To evaluate whether age, metabolic multimorbidity, and inflammatory–metabolic biomarkers are associated with acute obstructive presentation severity and early in-hospital length of stay.\"},{\"question\":\"How did the study define acute obstructive presentation?\",\"answer\":\"Acute presentation was categorized as no obstruction, subocclusive syndrome, or frank obstruction.\"},{\"question\":\"Which factors were independently associated with obstructive presentation and length of stay?\",\"answer\":\"Age was independently associated with obstructive presentation and greater severity. Length of stay was independently associated only with presentation severity, while inflammatory indices showed negligible correlations.\"}]","Metabolic Multimorbidity and Acute Obstructive Presentation in Colon Cancer: A 677-Patient Hospital-Based Cohort | PDF",48]