[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-382075-105":59,"doc-detail-382075-en":122},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":115,"head_meta":117,"extra_data":119,"updated_unix":121},105,"en","metabolic-health-mitochondrial-fitness-physical-activity-and-cancer-review","Metabolic Health, Mitochondrial Fitness, Physical Activity, and Cancer - Review","","Cancer remains a major global health challenge, and traditional genetic-centered strategies have often fallen short. Increasing attention is directed toward how the environment—especially inflammation and metabolism—shapes cancer development. This narrative review synthesizes evidence from multiple databases (MedLine/PubMed, Cochrane, Embase, PsychINFO, and CINAhl), emphasizing mitochondria as central regulators of metabolic health and key cancer-related processes, including apoptosis. It also discusses how “mitochondrial fitness” and exercise may improve mitochondrial function and potentially reduce cancer risk, while highlighting the need for further mechanistic research.",{"@graph":69,"@context":114},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/metabolic-health-mitochondrial-fitness-physical-activity-and-cancer-review/382075/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/metabolic-health-mitochondrial-fitness-physical-activity-and-cancer-review/382075.png","ImageObject",300,407,{"name":92,"@type":93},"hdkawk","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108],{"name":109,"@type":110,"acceptedAnswer":111},"How does physical activity relate to improving mitochondrial function and cancer risk?","Question",{"text":112,"@type":113},"The review highlights exercise—especially movement with high energy demand—as a powerful intervention to improve mitochondrial function. By supporting mitochondrial activity and countering environmental stressors, exercise may decrease the risk of cancer, though additional research is needed to clarify mechanisms.","Answer","https://schema.org",{"og:url":83,"og:type":116,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":118,"canonical":83},"index,follow",{"doc_id":120,"site_id":62},382075,1790546658,{"code":4,"msg":5,"data":123},{"doc_id":120,"user_id":124,"nickname":92,"user_avatar":125,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":126,"file_id":127,"file_url":128,"file_type":129,"file_size":130,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":131,"language":132,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":133,"faqs":134,"seo_title":135,"seo_description":67,"update_tm":136,"read_time":137},3985747859855,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","cancers   \nReview  \nMetabolic Health, Mitochondrial Fitness, Physical Activity, and Cancer  \nVicente Javier Clemente-Su¡rez 1, Alexandra Mart½n-Rodr½guez 1, Laura Redondo-Flârez 2, Pablo Ruisoto 3, Eduardo Navarro-Jim²nez 4, Domingo Jesós Ramos-Campo 5, * and Jos² Francisco Tornero-Aguilera 1  \nCitation: Clemente-Suárez, V.J.; Martín-Rodríguez, A.;  \nRedondo-Flórez, L.; Ruisoto, P.; Navarro-Jiménez, E.; Ramos-Campo, D.J.; Tornero-Aguilera, J.F. Metabolic Health, Mitochondrial Fitness, Physical Activity, and Cancer. Cancers 2023, 15, 814. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/cancers15030814](10.3390/cancers15030814)  \nAcademic Editors: Rodrigue Rossignoland Pierre Sonveaux  \nReceived: 25 December 2022  \nRevised: 26 January 2023  \nAccepted: 27 January 2023  \nPublished: 28 January 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Faculty of Sports Sciences, Universidad Europea de Madrid, Tajo Street, s/n, 28670 Madrid, Spain  \n2 Department of Health Sciences, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, C/Tajo s/n Villaviciosa de Odân, 28670 Madrid, Spain  \n3 Department of Health Sciences, Public University of Navarre, 31006 Navarre, Spain  \n4 Facultad de Ciencias de la Salud, Universidad Simân Bol½var, Barranquilla 080001, Colombia  \n5 Departamento de Salud y Rendimiento, Universidad Polit²cnica de Madrid, 28040 Madrid, Spain  \n* Correspondence: domingojesus.ramos@upm.es  \nSimple Summary: Recent research suggests a strong link between the functioning of mitochondria and the development of cancer. Healthy mitochondria play a vital role in maintaining metabolic processes and controlling cell death (apoptosis) . However, when inflammation persists for a long period of time, it can harm the mitochondria's ability to produce energy and manage cells, which in turn leads to tissue damage and hinders regeneration. Engaging in both endurance and resistance exercises, in addition to maintaining an active lifestyle, can help improve the functioning of mitochondria and may decrease the risk of cancer.  \nAbstract: Cancer continues to be a significant global health issue. Traditional genetic-based approaches to understanding and treating cancer have had limited success. Researchers are increasingly exploring the impact of the environment, specifically inflammation and metabolism, on cancer development. Examining the role of mitochondria in this context is crucial for understanding the connections between metabolic health, physical activity, and cancer. This study aimed to review the literature on this topic through a comprehensive narrative review of various databases including MedLine (PubMed), Cochrane (Wiley), Embase, PsychINFO, and CinAhl. The review highlighted the importance of mitochondrial function in overall health and in regulating key events in cancer development, such as apoptosis. The concept of “mitochondrial fitness” emphasizes the crucial role of mitochondria in cell metabolism, particularly their oxidative functions, and how proper function can prevent replication errors and regulate apoptosis. Engaging in high-energy-demanding movement, such as exercise, is a powerful intervention for improving mitochondrial function and increasing resistance to environmental stressors. These findings support the significance of considering the role of the environment, specifically inflammation and metabolism, in cancer development and treatment. Further research is required to fully understand the mechanisms by which physical activity improves mitochondrial function and potentially reduces the risk of cancer.  \nKeywords: metabolism; mitochondria; oxidative stress; inflammation; ph","cbCaiv6v2DWLTq1U","https://ap.wps.com/l/cbCaiv6v2DWLTq1U","pdf",953040,28,"English","# Introduction\n## Mitochondria functions and metabolic health\n## Link between mitochondrial dysfunction and cancer\n# Review scope and aims\n## Mitochondrial fitness and exercise as intervention","[{\"question\":\"How does physical activity relate to improving mitochondrial function and cancer risk?\",\"answer\":\"The review highlights exercise—especially movement with high energy demand—as a powerful intervention to improve mitochondrial function. By supporting mitochondrial activity and countering environmental stressors, exercise may decrease the risk of cancer, though additional research is needed to clarify mechanisms.\"}]","Metabolic Health, Mitochondrial Fitness, Physical Activity, and Cancer - Review | PDF",1790248898,71]