[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-337777-105":59,"doc-detail-337777-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","metabolic-factors-associated-with-endoscopic-atrophy-intestinal-metaplasia-and-gastric-neoplasms-in-helicobacter-pylori-positive-patients","Metabolic Factors Associated with Endoscopic Atrophy, Intestinal Metaplasia, and Gastric Neoplasms in Helicobacter pylori-Positive Patients","","Background: Previous studies link metabolic factors with Helicobacter pylori-related gastric cancer, but the relationship between gastric atrophy or intestinal metaplasia (IM) and these factors remains unclear. Methods: Data from 1603 H. pylori-positive patients who underwent esophagogastroduodenoscopy between 2001 and 2021 were analyzed. Endoscopic atrophy grade, IM grade, and confirmed gastric neoplasms were assessed, with associated clinical factors identified. Results: Advanced age, successful H. pylori eradication, and comorbidities including diabetes, hypertension, dyslipidemia, and fib4 index correlated with atrophy. IM correlated with male sex, advanced age, and additional comorbidities. Neoplasm incidence correlated with advanced age, eradication success, diabetes, fatty liver, and fib4 index. Conclusion: Metabolic disorders such as diabetes, hypertension, dyslipidemia, hyperuricemia, and fatty liver are risk factors for advanced gastric atrophy, IM, and gastric neoplasms, supporting metabolic risk stratification to guide EGD surveillance.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/metabolic-factors-associated-with-endoscopic-atrophy-intestinal-metaplasia-and-gastric-neoplasms-in-helicobacter-pylori-positive-patients/337777/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/metabolic-factors-associated-with-endoscopic-atrophy-intestinal-metaplasia-and-gastric-neoplasms-in-helicobacter-pylori-positive-patients/337777.png","ImageObject",300,407,{"name":92,"@type":93},"Ivy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",14,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the study purpose regarding metabolic factors in H. pylori-positive patients?","Question",{"text":113,"@type":114},"To determine whether gastric atrophy grade, intestinal metaplasia (IM) grade, and gastric neoplasms are associated with metabolic factors in H. pylori-positive patients.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which metabolic and clinical factors were linked to endoscopic gastric atrophy grade?",{"text":118,"@type":114},"Advanced age, successful H. pylori eradication, and comorbidities including diabetes mellitus, hypertension, dyslipidemia, and fib4 index were significantly associated with advanced atrophy grade.",{"name":120,"@type":111,"acceptedAnswer":121},"How do the findings suggest surveillance should be adjusted for H. pylori-positive patients?",{"text":122,"@type":114},"Risk stratification using these metabolic factors—especially metabolic disorders—could influence endoscopic (EGD) surveillance to better prevent progression to gastric neoplasms.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},337777,1790436833,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},549758252649,"https://ap-avatar.wpscdn.com/avatar/8000253669c5317157?_k=1778319167496531819","Article  \nMetabolic Factors Associated with Endoscopic Atrophy, Intestinal Metaplasia, and Gastric Neoplasms in Helicobacter pylori-Positive Patients  \nJunya Arai 1,2, *, Hiroaki Fujiwara 1,2, Tomonori Aoki 2, Ryota Niikura 3, Sozaburo Ihara 2, Nobumi Suzuki 2, Yoku Hayakawa 2, Masato Kasuga 4 and Mitsuhiro Fujishiro 2  \nCitation: Arai, J.; Fujiwara, H.; Aoki, T.; Niikura, R.; Ihara, S.; Suzuki, N.; Hayakawa, Y.; Kasuga, M.; Fujishiro, M. Metabolic Factors Associated with Endoscopic Atrophy, Intestinal Metaplasia, and Gastric Neoplasms in Helicobacter pylori-Positive Patients. Clin. Pract. 2024, 14, 779–788 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)clinpract14030062  \nAcademic Editors: Dirk Radesand Jakov Mihanovic  \nReceived: 5 February 2024  \nRevised: 16 April 2024  \nAccepted: 6 May 2024  \nPublished: 8 May 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Division of Gastroenterology, The Institute of Medical Science, Asahi Life Foundation, Tokyo 103-0002, Japan; [hfujiwara29@gmail.com](hfujiwara29@gmail.com)  \n2 Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan; [sozaburo.ihara@gmail.com](sozaburo.ihara@gmail.com) (S.I.); [nobu3szk@gmail.com](nobu3szk@gmail.com) (N.S.); [hayakawayoku@gmail.com](hayakawayoku@gmail.com) (Y.H.); [mtfujish@gmail.com](mtfujish@gmail.com) (M.F.)  \n3 Department of Endoscopy, Graduate School of Medicine, Tokyo Medical University, Tokyo 160-0023, Japan; [rniikuratritonocn@gmail.com](rniikuratritonocn@gmail.com)  \n4 The Institute of Medical Science, Asahi Life Foundation, Tokyo 103-0002, Japan; [m-kasuga@asahi-life.or.jp](m-kasuga@asahi-life.or.jp)  \n* Correspondence: [ayayadejunyatoyomu@gmail.com](ayayadejunyatoyomu@gmail.com); Tel.: +81-3-3639-5501  \nAbstract: Background: Previous studies demonstrate an association between metabolic factors and Helicobacter pylori-related gastric cancer. However, the association of gastric atrophy or intestinal metaplasia (IM) with these factors remains unknown. Methods: Data on 1603 Helicobacter pylori-positive patients who underwent esophagogastroduodenoscopy between 2001 and 2021 were evaluated. The outcome measures were endoscopic atrophy, IM grade, and the incidence of endoscopically diagnosed and pathologically confirmed gastric neoplasms. Clinical factors associated with these findings were also determined. Results: Advanced age; successful Helicobacter pylori eradication; and comorbidities including diabetes mellitus (DM), hypertension, dyslipidemia, and fib4 index were significantly associated with endoscopic gastric atrophy grade. Male sex; advanced age; and comorbidities including DM, hypertension, dyslipidemia, hyperuricemia, fatty liver, aortic calcification, and fib4 index were also significantly associated with endoscopic IM grade, whereas advanced age, successful Helicobacter pylori eradication, DM, fatty liver, and fib4 index were significantly associated with the incidence of gastric neoplasms. Conclusion: Several metabolic disorders, including DM, hypertension, dyslipidemia, hyperuricemia, and fatty liver disease, are risk factors for advanced-grade gastric atrophy, intestinal metaplasia, and gastric neoplasms. Risk stratification according to these factors, particularly those with metabolic disorders, would affect EGD surveillance for Helicobacter pylori-positive patients.  \nKeywords: Helicobacter pylori; gastric atrophy; intestinal metaplasia; gastric neoplasms; fatty liver; diabetes mellitus  \n1. Introduction  \nGastric cancer (GC) is the third leading cause of cancer-related mortality worldwide [1] . The main carcinogen in gastric ca","cbCaioYoxfiQTTyO","https://ap.wps.com/l/cbCaioYoxfiQTTyO","pdf",1353676,"English","# Abstract\n# Keywords\n# 1. Introduction\n# 2. Materials and Methods\n## 2.1. Study Design, Setting, and Patients","[{\"question\":\"What was the study purpose regarding metabolic factors in H. pylori-positive patients?\",\"answer\":\"To determine whether gastric atrophy grade, intestinal metaplasia (IM) grade, and gastric neoplasms are associated with metabolic factors in H. pylori-positive patients.\"},{\"question\":\"Which metabolic and clinical factors were linked to endoscopic gastric atrophy grade?\",\"answer\":\"Advanced age, successful H. pylori eradication, and comorbidities including diabetes mellitus, hypertension, dyslipidemia, and fib4 index were significantly associated with advanced atrophy grade.\"},{\"question\":\"How do the findings suggest surveillance should be adjusted for H. pylori-positive patients?\",\"answer\":\"Risk stratification using these metabolic factors—especially metabolic disorders—could influence endoscopic (EGD) surveillance to better prevent progression to gastric neoplasms.\"}]","Metabolic Factors Associated with Endoscopic Atrophy, Intestinal Metaplasia, and Gastric Neoplasms in Helicobacter pylori-Positive Patients | PDF",1790020578,25]