[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-56195-en":3,"doc-seo-56195-105":29,"detail-sidebar-cat-0-en-105":91},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":20,"is_deleted":4,"is_public":20,"is_downloadable":20,"audit_status":20,"page_count":21,"language":22,"language_code":23,"site_id":24,"html_lang":23,"table_of_contents":25,"faqs":26,"seo_title":13,"seo_description":14,"update_tm":27,"read_time":28},56195,8796095462418,"Noah","https://ap-avatar.wpscdn.com/avatar/80000253c1241d02b47?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778826106357471780",8,"Research & Report","Metabolic Effects of D-Psicose in Rats","Metabolic effects of D-psicose were studied in Wistar rats to clarify absorption, excretion, and caecal fermentation after oral intake. Rats received D-psicose at 5 g/kg body weight, and urinary and faecal excretion over 24 h after a single dose was quantified. Serum levels and intestinal contents showed progressive decline after dosing, while caecal detection occurred after 3–7 h. Diets containing D-psicose induced short-chain fatty acid production and caecal hypertrophy, indicating partial digestive absorption and microflora-mediated fermentation.","Original Article  \nMetabolic effects of D-psicose in rats: studies on faecal and urinary excretion and caecal fermentation  \nTatsuhiro Matsuo PhD, Tomohiro Tanaka BSc, Mineo Hashiguchi PhD, Ken Izumori PhD and Hiroo Suzuki PhD  \nFaculty of Agriculture, Kagawa University, Ikenobe, Miki-cho, Kita-gun, Kagawa, Japan  \nD-Psicose (D -ribo-2-hexulose), a C-3 epimer of D-fructose, is one of the “rare sugars” present in small quantities in commercial carbohydrate complex or agricultural products. We investigated the absorption and excretion of D-psicose when orally administrated (5g/kg body weight) to Wistar rats, and the fermentation of D-psicose was measured as caecal short-chain fatty acids (SCFAs) when fed to rats in controlled diets (0, 10, 20 and 30%) . Urinary and faecal excretions ofD-psicose over the 24 h, following a single oral administration, were 11-15% of dosage for the former and 8-13% of dosage for the latter. Serum D-psicose concentration and D-psicose in the contents of stomach and small intestines decreased progressively after administration. D-psicose in caecum contents was detected after 3 h and 7 h administration, but not after 1 h. Rats fed on D-psicose diets showed short-chain fatty acid production with caecal hypertrophy. These results suggest that D-psicose is partly absorbable in the digestive tract and is excreted into urine and faeces. As with other poorly absorbed dietary carbohydrates, D-psicose is fermented in the caecum by intestinal microflora.  \nKey words: D-psicose, D-fructose, fermentable sugars, short chain fatty acids, faecal/urinary excretion, fermentation, Japan  \nIntroduction  \nD-Psicose (D-ribo-2-hexulose), a C-3 epimer of D-fructose, isone of the “rare sugars” present in small quantities in commercial mixtures of D-glucose and D-fructose obtained from hydrolysis of sucrose or isomerization of D-glucose.1 D-psicose is also present in processed cane and beet molasses,2 and is found in wheat,3 Itea plants,4 and in the antibiotic psicofranine.5 Because of the very small amounts of D-psicose in natural products, few studies have examined D-psicose metabolism in animals.  \nRecently, we developed a new method to produce D-psicose enzymatically on a large scale.6 Moreover, we have suggested that certain D-psicose supplements suppress hepatic lipogenic enzyme activity and reduce intra-abdominal fat accumulation compared to D-glucose or D-fructose in rats.7 Wistler et al.,8 reported that when D-[U-14C] psicose was orally administrated by stomach tube into fasting rats, 39% of the radioactivity was retained by the carcass for the following 72 h. This finding suggested that a large portion of D-psicose was metabolized by intestinal microorganisms into byproducts, some of which would be absorbed into the animal’s metabolic system. However, D-psicose metabolism in animal digestive tracts (absorption, excretion, or fermentation) remains largely unknown.  \nIn this study, we investigated the absorption and excretion of D-psicose by high performance liquid chromatograpgy  \n(HPLC) when given orally, and fermentation of D-psicose when fed to rats in controlled diets. We found that in rats D-psicose is a fermentable sugar and that it produces shortchain fatty acids (SCFAs) in the caecum.  \nMethods  \nAll procedures involving animals were approved by the Experimental Animal Care Committee of the Kagawa University.  \nThree experiments were conducted using male Wistar rats obtained from Japan SLC (Shizuoka, Japan) . Animals were individually housed in a room regulated at a temperature of 24 ± 2 ˚C and lit from 08:00 to 20:00 h. Rats were fed CE-2, a commercial rodent diet (CLEA, Tokyo, Japan) before experimental treatment.  \nCorrespondence address: Dr Tatsuhiro Matsuo, Faculty of Agriculture, Kagawa University, 2393 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0795, Japan  \nTel: 81-87-891-3082; Fax: 81-87-891-3021  \n[Email: matsuo@ag.kagawa-u.ac.jp](Email: matsuo@ag.kagawa-u.ac.jp)[ ](Email: matsuo@ag.kagawa-u.ac.jp)Acce","cbCaigZ70N0TAtmT","https://ap.wps.com/l/cbCaigZ70N0TAtmT","pdf",157148,1,7,"English","en",105,"# Key Findings\n## Absorption and systemic levels\n## Urinary and faecal excretion\n## Caecal fermentation and SCFAs\n# Introduction\n## Background on rare sugars\n## Knowledge gap in animal metabolism\n## Study aim and rationale\n# Methods\n## Ethical approval and animal care\n## Experimental design and housing\n# Experiment 1: Excretion Studies\n## Animals and dosing\n## Sample collection\n## HPLC analysis\n# Experiment 2: Absorption Studies\n## Animals and dosing\n## Sampling schedule","[{\"question\":\"How much D-psicose was administered to the rats, and how were excretion outcomes measured?\",\"answer\":\"Rats were orally given D-psicose at 5 g/kg body weight. Urine and faeces were collected over time and assayed by HPLC with refractive index detection.\"},{\"question\":\"What did the study observe about D-psicose levels in blood and gastrointestinal contents after dosing?\",\"answer\":\"Serum D-psicose concentration and D-psicose in stomach and small intestine contents decreased progressively after administration.\"},{\"question\":\"How did D-psicose affect caecal fermentation, and what related markers were reported?\",\"answer\":\"D-psicose in caecum contents was detected after 3 h and 7 h dosing, and rats fed D-psicose diets showed production of short-chain fatty acids with caecal hypertrophy, supporting fermentation by intestinal microflora.\"}]",1783719265,18,{"code":4,"msg":30,"data":31},"ok",{"site_id":24,"language":23,"slug":32,"title":13,"keywords":33,"description":14,"schema_data":34,"social_meta":86,"head_meta":88,"extra_data":90,"updated_unix":27},"metabolic-effects-of-d-psicose-in-rats","",{"@graph":35,"@context":85},[36,53,68],{"@type":37,"itemListElement":38},"BreadcrumbList",[39,43,47,50],{"item":40,"name":41,"@type":42,"position":20},"https://docshare.wps.com","Home","ListItem",{"item":44,"name":45,"@type":42,"position":46},"https://docshare.wps.com/document/","Document",2,{"item":48,"name":12,"@type":42,"position":49},"https://docshare.wps.com/document/research-report/",3,{"item":51,"name":13,"@type":42,"position":52},"https://docshare.wps.com/document/metabolic-effects-of-d-psicose-in-rats/56195/",4,{"url":51,"name":13,"@type":54,"author":55,"headline":13,"publisher":57,"fileFormat":60,"inLanguage":23,"description":14,"dateModified":61,"datePublished":62,"encodingFormat":60,"isAccessibleForFree":63,"interactionStatistic":64},"DigitalDocument",{"name":9,"@type":56},"Person",{"url":40,"name":58,"@type":59},"DocShare","Organization","application/pdf","2026-07-17","2026-07-10",true,{"@type":65,"interactionType":66,"userInteractionCount":20},"InteractionCounter",{"@type":67},"ViewAction",{"@type":69,"mainEntity":70},"FAQPage",[71,77,81],{"name":72,"@type":73,"acceptedAnswer":74},"How much D-psicose was administered to the rats, and how were excretion outcomes measured?","Question",{"text":75,"@type":76},"Rats were orally given D-psicose at 5 g/kg body weight. Urine and faeces were collected over time and assayed by HPLC with refractive index detection.","Answer",{"name":78,"@type":73,"acceptedAnswer":79},"What did the study observe about D-psicose levels in blood and gastrointestinal contents after dosing?",{"text":80,"@type":76},"Serum D-psicose concentration and D-psicose in stomach and small intestine contents decreased progressively after administration.",{"name":82,"@type":73,"acceptedAnswer":83},"How did D-psicose affect caecal fermentation, and what related markers were reported?",{"text":84,"@type":76},"D-psicose in caecum contents was detected after 3 h and 7 h dosing, and rats fed D-psicose diets showed production of short-chain fatty acids with caecal hypertrophy, supporting fermentation by intestinal microflora.","https://schema.org",{"og:url":51,"og:type":87,"og:title":13,"og:site_name":58,"og:description":14},"article",{"robots":89,"canonical":51},"index,follow",{"doc_id":7,"site_id":24},{"code":4,"msg":5,"data":92},[93,97,101,105,110,115,119,122,127,130,134],{"id":20,"doc_module":4,"doc_module_name":45,"category_name":94,"show_sort_weight":95,"slug":96},"Story & Novel",90,"story-novel",{"id":46,"doc_module":4,"doc_module_name":45,"category_name":98,"show_sort_weight":99,"slug":100},"Literature",80,"literature",{"id":52,"doc_module":4,"doc_module_name":45,"category_name":102,"show_sort_weight":103,"slug":104},"Exam",70,"exam",{"id":106,"doc_module":4,"doc_module_name":45,"category_name":107,"show_sort_weight":108,"slug":109},5,"Comic",60,"comic",{"id":111,"doc_module":4,"doc_module_name":45,"category_name":112,"show_sort_weight":113,"slug":114},6,"Technology",50,"technology",{"id":21,"doc_module":4,"doc_module_name":45,"category_name":116,"show_sort_weight":117,"slug":118},"Healthcare",40,"healthcare",{"id":11,"doc_module":4,"doc_module_name":45,"category_name":12,"show_sort_weight":120,"slug":121},30,"research-report",{"id":123,"doc_module":4,"doc_module_name":45,"category_name":124,"show_sort_weight":125,"slug":126},9,"Religion & Spirituality",20,"religion-spirituality",{"id":125,"doc_module":4,"doc_module_name":45,"category_name":128,"show_sort_weight":125,"slug":129},"World Cup","world-cup",{"id":131,"doc_module":4,"doc_module_name":45,"category_name":132,"show_sort_weight":131,"slug":133},10,"Lifestyle","lifestyle",{"id":135,"doc_module":4,"doc_module_name":45,"category_name":136,"show_sort_weight":106,"slug":137},19,"General","general"]