[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-436045-105":59,"doc-detail-436045-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","metabolic-consequences-and-tubular-function-after-augmentation-cystoplasty-in-children-with-neurogenic-bladder","Metabolic consequences and tubular function after augmentation cystoplasty in children with neurogenic bladder","","Study examined metabolic disturbances, renal tubular function, and 24-hour urine chemistry in children undergoing augmentation cystoplasty (AC) for neurogenic bladder, focusing on how metabolic alterations relate to urolithiasis risk. Serum biochemistry, blood gas, and 24-hour urinary metabolic profiles were evaluated across patients followed for a mean of 13.8 years. Results assessed metabolic complications, tubular function indices, and magnesium status.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/metabolic-consequences-and-tubular-function-after-augmentation-cystoplasty-in-children-with-neurogenic-bladder/436045/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/metabolic-consequences-and-tubular-function-after-augmentation-cystoplasty-in-children-with-neurogenic-bladder/436045.png","ImageObject",300,407,{"name":92,"@type":93},"Hazel","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main focus of the study after augmentation cystoplasty (AC)?","Question",{"text":112,"@type":113},"The study evaluated the prevalence of metabolic disturbances and renal tubular function changes, and how 24-hour urine metabolic findings associate with urolithiasis after AC.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What data were collected to assess metabolic and tubular function changes?",{"text":117,"@type":113},"Serum biochemistry, blood gas, and 24-hour urinary metabolic profiles were analyzed, including metabolic complications, tubular function measures, and magnesium-related status.",{"name":119,"@type":110,"acceptedAnswer":120},"What conclusion did the study reach about metabolic impact and urolithiasis?",{"text":121,"@type":113},"AC was considered safe with no significant overall impact on the metabolic profile, and several urinary metabolic excretions were not associated with urolithiasis, though magnesium excretion abnormalities were common.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},436045,1790740532,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},137441390410,"https://ap-avatar.wpscdn.com/avatar/2000252f4ab5702993?_k=1776741390130283984","J Chin MedAssoc  \nOriginal article  \nMetabolic consequences and tubular function after augmentation cystoplasty in children with neurogenic bladder  \nJei-Wen Changa,b,c, Hui-Hsin Yangb,d, Tzu-Ching Lina,b, Fang-Cheng Kuob,d, Yu-Hua Fanb,e, Hsin-Hung Chenb,f, Ling-Yu Yangb,g, Chin-Su Liub,d, Hsin-Lin Tsaib,d,*  \naDepartment of Pediatrics, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; bFaculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC; cInstitute of Emergency and Critical Care Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC; dDivision of Pediatric Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; eDepartment of Urology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; fDepartment of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; gDepartment of Medical Education, Taipei Veterans General Hospital, Taipei, Taiwan, ROC  \nAbstract  \nBackground: While many studies have reported the renal outcomes and metabolic consequences of augmentation cystoplasty (AC), few have focused on changes in renal tubular function. This study investigated the prevalence of metabolic disturbances, renal tubular function, and 24-hour urine chemistry, aiming to evaluate the association between metabolic alterations and urolithiasis after AC.  \nMethods: We investigated serum biochemistry, blood gas, and 24-hour urinary metabolic profile of children who underwent AC between January 2000 and December 2020. The assessed outcomes included metabolic complications, tubular function, and magnesium status. Associations between 24-hour urinary metabolic parameters and urolithiasis formation were also examined. Results: A total of 25 patients with a mean follow-up period of 13.8 ± 5.7 years were enrolled. The mean age at AC was 7.5 ± 4.4 years, and 22 and 3 patients underwent AC using the ileum and colon, respectively. There were no abnormalities in serum levels of sodium, potassium, chloride, and calcium. Hypomagnesemia (magnesium \u003C1 .7 mg/dL) due to renal loss was observed in one patient (4.0%) . Six (24.0%) patients had increased urinary β2-microglobulin levels and normal serum levels. The ratio of the maximum rate of tubular phosphate reabsorption to the glomerular filtration rate was low in three (12 .0%) patients. Four (16 .0%) patients had normal serum magnesium levels but urinary magnesium excretion \u003C40 mg/d. Urolithiasis occurred in 11 patients (44 .0%) . The most common 24-hour urine metabolic abnormality was hypomagnesiuria (72 .0%) . No urinary metabolic parameters or daily protein intake were associated with urolithiasis.  \nConclusion: AC for children is safe and does not significantly impact the metabolic profile. Excretions of 24-hour urinary calcium, uric acid, magnesium, and the sodium-to-potassium ratio were not associated with urolithiasis. However, a high prevalence of 24-hour urine magnesium excretion \u003C88 mg/1 .73 m2 was noted. Further prospective studies are needed to investigate longitudinal changes in renal tubular function and 24-hour urine metabolic profiles, particularly magnesium status.  \nKeywords: Augmentation cystoplasty; Children; Magnesium; Neurogenic bladder; Renal tubular function  \n1. INTRODUCTION  \nAugmentation cystoplasty (AC) is a surgery performed in children with low capacity, poor detrusor compliance, or  \n*Address correspondence. Dr. Hsin-Lin Tsai, Division of Pediatric Surgery, Department of Surgery, Taipei Veterans General Hospital, 201 Section 2, Shi-Pai Road, Taipei 112, Taiwan, [ROC. E-mail address: hltsai@vghtpe.gov.tw](ROC. E-mail address: hltsai@vghtpe.gov.tw) (H.-L. Tsai). Conflicts of interest: Dr. Jei-Wen Chang and Dr. Chin-Su Liu, editorial board members at the Journal of the Chinese Medical Association, have no roles in the peer review process of or decision to publish this article. The other authors declare that they have ","cbCaiix2dqn6OOWu","https://ap.wps.com/l/cbCaiix2dqn6OOWu","pdf",380657,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Introduction\n## Augmentation cystoplasty indications and outcomes\n## Metabolic acidosis and electrolyte changes\n## Risks related to ileum/colon and magnesium","[{\"question\":\"What was the main focus of the study after augmentation cystoplasty (AC)?\",\"answer\":\"The study evaluated the prevalence of metabolic disturbances and renal tubular function changes, and how 24-hour urine metabolic findings associate with urolithiasis after AC.\"},{\"question\":\"What data were collected to assess metabolic and tubular function changes?\",\"answer\":\"Serum biochemistry, blood gas, and 24-hour urinary metabolic profiles were analyzed, including metabolic complications, tubular function measures, and magnesium-related status.\"},{\"question\":\"What conclusion did the study reach about metabolic impact and urolithiasis?\",\"answer\":\"AC was considered safe with no significant overall impact on the metabolic profile, and several urinary metabolic excretions were not associated with urolithiasis, though magnesium excretion abnormalities were common.\"}]","Metabolic consequences and tubular function after augmentation cystoplasty in children with neurogenic bladder | PDF",1790676548,15]