[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331698-105":59,"doc-detail-331698-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","meta-analysis-of-prognostic-significance-of-cancer-stem-cell-markers-in-oral-squamous-cell-carcinoma","Meta-Analysis of Prognostic Significance of Cancer Stem Cell Markers in Oral Squamous Cell Carcinoma","","Objective: Evaluate the debated prognostic value of cancer stem cell markers in oral squamous cell carcinoma, focusing on CD44, CD24, CD133, and ALDH as indicators of cancer stem cell-like cells. Methods: Analyze these markers across 19 retrospective studies and compute risk ratios and odds ratios for 3-year survival and clinicopathological associations using a fixed-effects model. Results: CD133 relates to poor prognosis, while ALDH associates with lymph node metastasis and clinical staging. Conclusion: CSC markers may predict oral cancer outcomes and support targeted treatment strategies.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/meta-analysis-of-prognostic-significance-of-cancer-stem-cell-markers-in-oral-squamous-cell-carcinoma/331698/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/meta-analysis-of-prognostic-significance-of-cancer-stem-cell-markers-in-oral-squamous-cell-carcinoma/331698.png","ImageObject",300,407,{"name":92,"@type":93},"Aurelia","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Which cancer stem cell markers were evaluated for prognostic significance in OSCC?","Question",{"text":113,"@type":114},"The study assessed CD44, CD24, CD133, and ALDH as cancer stem cell marker indicators in oral squamous cell carcinoma.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were the relationships between markers and outcomes analyzed?",{"text":118,"@type":114},"Nineteen retrospective studies were analyzed, and risk ratios (RRs) and odds ratios (ORs) were calculated for 3-year survival and clinicopathological parameters using a fixed-effects model.",{"name":120,"@type":111,"acceptedAnswer":121},"What prognostic findings were reported for CD133 and ALDH?",{"text":122,"@type":114},"CD133 expression was linked to poor prognosis, while ALDH expression significantly correlated with lymph node metastasis and clinical staging.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},331698,1790069279,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":105,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1099514068365,"https://ap-avatar.wpscdn.com/avatar/10000253d8d9f28188e?x-image-process=image/resize,m_fixed,w_180,h_180&k=1794309523707217728","RESEARCH ARTICLE  \nEditorial Process: Submission:05/14/2024 Acceptance:10/07/2024  \nMeta-Analysis of Prognostic Significance of Cancer Stem Cell Markers in Oral Squamous Cell Carcinoma  \nAbhilasha Tripathi1, Mohit Singh2, Prabhaker Mishra3, Naseem Fatima4, Vijay Kumar2 *  \nAbstract  \nObjective: Researchers have shown significant interest in cancer stem cells in recent years. CD44, CD24, CD133, and ALDH serve as indicators of cancer stem cell-like cells in Oral Squamous Cell Carcinoma. However, the prognostic significance of these Cancer Stem Cell markers in Squamous Cell Carcinoma is still debated. This study employed metaanalysis to evaluate the prognostic significance of cancer stem cells about Oral Squamous Cell Carcinoma. Methods: CD44, CD133, CD24, and ALDH markers were analyzed in 19 retrospective studies to determine their relationship with prognosis and clinicopathological parameters. Risk ratios (RRs) and odds ratios (ORs) were calculated for 3-years survival rates and clinicopathological parameters, respectively, using a fixed-effects model. Result: The finding of our study based on extracted survival rates showed that cancer stem cell markers, CD133 expression was related with the poor prognosis (RR= 1.62 ,95% CI = 1.08-2.44, P= 0.02) . ALDH expression significantly correlated with lymph node metastasis (OR= 4.13, 95% Cl= 1.88-9.10, P\u003C0.001) and clinical staging (OR= 2.26, 95% CI= 1.05-4.88, P= 0.04) . Conclusion: The findings indicate that CSC markers could be used to predict oral cancer prognosis. Our study contributes to the literature on survival outcomes of Oral Squamous Cell Carcinoma. These findings offer a structure for the advancement of cancer treatments that specifically target cancer stem cells. Conducting additional studies with a broader group of patients will help confirm the role of cancer stem cells as dependable predictors of prognosis.  \nKeywords: oral squamous cell carcinoma-cancer stem cell marker-prognosis-clinicopathological parameters  \nAsian Pac J Cancer Prev, 25 (10), 3597-3607  \nIntroduction  \nOral squamous cell carcinoma (OSCC) ranks asthe sixth most prevalent malignancy globally [1] . The global incidence of oral cancer in 2020 was expected tobe 377,713 cases, resulting in 177,757 deaths [2] . There has been a continuous increase in new cases of OSCC worldwide every year. Oral cavity cancer is quite prevalent in India, representing approximately 30% of the total global cases [3] .  \nSmoking and alcohol consumption are the primary risk factors for oral cancer in developed countries, while chewing tobacco is the predominant cause of oral cancer in South Asia, particularly India [4] . Conventionally, lymph node metastasis (number and size of lymph nodes and extra nodal extension) is the furthermost significant prognostic factor, resulting in a 50% decrease in survival [5] . Additional characteristics that influence the prognosis include the size of the tumor, the degree of differentiation, the presence of perineural invasion (PNI), and lymphovascular invasion (LVI) in the initial lesion [6,  \n7]. Over the years, improvements in surgery, radiotherapy techniques, new chemotherapeutic agents, and monoclonal antibodies have improved the prognosis of this cancer.  \nDespite current treatment modalities, the prognosis for OSCC remains poor, as more than half of the patients die within five years [8]. A subset of patients with earlystage disease has poor outcomes, and some advanced stages of cancer have relatively better outcomes in terms of recurrence and survival. A small minority of patients do not exhibit a response to chemotherapy and radiotherapy, or they acquire resistance to these treatments. CSC exhibits strong tumorigenicity, self-renewal, and differentiation capabilities which maintain cancer. Additionally, these cells are capable of drug resistance and immune evasion. Owing to their rapid immunophenotypic changes, CSCs are difficult to identify using specific markers in tissue and blood","cbCaiav7ZN1y05us","https://ap.wps.com/l/cbCaiav7ZN1y05us","pdf",4020931,"English","# Abstract\n## Objective\n## Methods\n## Results\n## Conclusion\n# Introduction\n# Materials and Methods","[{\"question\":\"Which cancer stem cell markers were evaluated for prognostic significance in OSCC?\",\"answer\":\"The study assessed CD44, CD24, CD133, and ALDH as cancer stem cell marker indicators in oral squamous cell carcinoma.\"},{\"question\":\"How were the relationships between markers and outcomes analyzed?\",\"answer\":\"Nineteen retrospective studies were analyzed, and risk ratios (RRs) and odds ratios (ORs) were calculated for 3-year survival and clinicopathological parameters using a fixed-effects model.\"},{\"question\":\"What prognostic findings were reported for CD133 and ALDH?\",\"answer\":\"CD133 expression was linked to poor prognosis, while ALDH expression significantly correlated with lymph node metastasis and clinical staging.\"}]","Meta-Analysis of Prognostic Significance of Cancer Stem Cell Markers in Oral Squamous Cell Carcinoma | PDF",1789994742,28]