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The review focuses on recent evidence in genitourinary neoplasms, covering prostatic, ovarian, cervical, endometrial, bladder, and renal cell cancers. It highlights MSC-derived exosomes for delivering effective RNAs, offering extensive tissue compatibility, and supporting tumor identification, as a potential future therapeutic approach compared with limitations of cell therapy.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/mesenchymal-stromalstem-cell-derived-exosomes-and-genitourinary-cancers-a-mini-review/378592/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/mesenchymal-stromalstem-cell-derived-exosomes-and-genitourinary-cancers-a-mini-review/378592.png","ImageObject",300,407,{"name":92,"@type":93},"dhado","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-02","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the main focus of this mini review?","Question",{"text":113,"@type":114},"The mini review concentrates on recent information about MSC-derived exosomes and their capabilities in genitourinary neoplasms, including multiple cancer types.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Why is the role of stem-cell extracellular vesicles in cancer considered controversial?",{"text":118,"@type":114},"The document states the impact is debatable and appears to depend on the EV source, the tumor type, and the mode of exosome therapy.",{"name":120,"@type":111,"acceptedAnswer":121},"Which genitourinary cancer categories are discussed?",{"text":122,"@type":114},"It lists prostatic neoplasms, ovarian neoplasms, cervical neoplasms, endometrial neoplasms, bladder neoplasms, and renal cell neoplasms.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},378592,1790362997,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},5909893218464,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","TYPE Mini Review  \nPUBLISHED 04 January 2023 DOI 10.3389/fcell.2022.1115786  \nOPEN ACCESS  \nEDITED BY  \nReza Shirazi,  \nUNSW Sydney, Australia  \nREVIEWED BY  \nUlanbek Zhanbyrbekuly,  \nAstana Medical University, Kazakhstan Mohammad Saied Salehi,  \nShiraz University of Medical Sciences, Iran  \nSahar Almasi-Turk,  \nBushehr University of Medical Sciences, Iran  \n*CORRESPONDENCE  \nFarhad Rahmanifar,  \n [rahmanifar@shirazu.ac.ir](rahmanifar@shirazu.ac.ir),  \n [f.rahmanifar@yahoo.com](f.rahmanifar@yahoo.com)  \nSPECIALTY SECTION  \nThis article was submitted to Stem Cell Research,  \na section of the journal  \nFrontiers in Cell and Developmental Biology  \nRECEIVED 04 December 2022  \nACCEPTED 14 December 2022  \nPUBLISHED 04 January 2023  \nCITATION  \nSalehpour A, Balmagambetova S, Mussin N, Kaliyev A and Rahmanifar F (2023), Mesenchymal stromal/stem cell-derived exosomes and genitourinary cancers: A mini review.  \nFront. Cell Dev. Biol. 10:1115786 .  \ndoi: 10.3389/fcell.2022.1115786  \nCOPYRIGHT  \n© 2023 Salehpour, Balmagambetova, Mussin, Kaliyev and Rahmanifar. This isan open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nMesenchymal stromal/stem cell-derived exosomes and genitourinary cancers: A mini review  \nAria Salehpour 􀀁 1, Saule Balmagambetova 􀀁 2, Nadiar Mussin 􀀁 3, Asset Kaliyev 􀀁 3 and Farhad Rahmanifar 􀀁 4*  \n1PerciaVista R&D Co. Ltd, Shiraz, Iran, 2Department of Oncology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan, 3Department of Surgery No. 2, West Kazakhstan Medical University, Aktobe, Kazakhstan, 4Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran  \nMesenchymal stromal/stem cell- (MSC-) derived exosomes are gaining popularity for their involvement in tissue repair and repressing various tumors through extensive patterns. Nevertheless, the impact of extracellular vesicles produced by stem cells on tumor formation and progression is controversial and seems to depend on several factors. The utilization of MSCs’ various capabilities in urogenital neoplasms is widely regarded as a potential future therapeutic as well. These genitourinary neoplasms include prostatic neoplasms, ovarian neoplasms, cervical neoplasms, endometrial neoplasms, bladder neoplasms, and renal cell neoplasms. The present study has concentrated on the most recent information on genitourinary neoplasms employing MSCs derived exosomes’ many capabilities, such as delivering effective RNAs, extensive tissue compatibility, and specificity with tumor identification without inherent limitations of cell therapy.  \nKEYWORDS  \nMesenchymal Stromal/Stem Cell, MSCs, Exosomes, miRNAs, Urogenital neoplasms, Genitourinary neoplasms, Reproductive neoplasms, Reproductive cancers  \nAbbreviations: CDKs, cyclin-dependent kinases; PCa, Prostate cancer; CRPC, Castration-resistant prostate cancer; EC, Endometrial cancer; EVs, Extracellular vesicles; EXO, Exosome; hA-MSC-CM, human adipose tissue-derived mesenchymal stromal/stem cell condition media; hBM-MSC, Human bone marrow-derived mesenchymal stromal/stem cell; hL-SCs, Human liver stem cells; hUC-MSC, human umbilical cord-derived mesenchymal stromal/stem cell; lncRNA, Long non-coding RNA; MenSCs, Menstrual blood-derived stem cells; MEST, mesoderm-specific transcript; miRNA, microRNA; mir, microRNA; MSC, Mesenchymal stromal/stem cell; MSC-EXO, Mesenchymal stromal/stem cellderived exosome; OCa, Ovarian cancer; ROS, Reactive oxygen species; SEPT2, Septin 2; WT, Wilms tumor.  \nFrontiers in Cell and Developmental Biology 01 [frontiersin.org](frontiersin.org)  \nMesenchymal stromal/stem cell","cbCaigfAGc7YUYRl","https://ap.wps.com/l/cbCaigfAGc7YUYRl","pdf",1075705,"English","# Mesenchymal stromal/stem cell-derived exosomes and genitourinary neoplasms\n## MSCs and their immunomodulatory functions\n## Exosomes in diagnosing genitourinary neoplasms\n## MSC-derived exosomes as therapeutic carriers\n## Therapeutic relevance and current controversies","[{\"question\":\"What is the main focus of this mini review?\",\"answer\":\"The mini review concentrates on recent information about MSC-derived exosomes and their capabilities in genitourinary neoplasms, including multiple cancer types.\"},{\"question\":\"Why is the role of stem-cell extracellular vesicles in cancer considered controversial?\",\"answer\":\"The document states the impact is debatable and appears to depend on the EV source, the tumor type, and the mode of exosome therapy.\"},{\"question\":\"Which genitourinary cancer categories are discussed?\",\"answer\":\"It lists prostatic neoplasms, ovarian neoplasms, cervical neoplasms, endometrial neoplasms, bladder neoplasms, and renal cell neoplasms.\"}]","Mesenchymal stromal/stem cell-derived exosomes and genitourinary cancers - A mini review | PDF",1790231348,25]