[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-412997-105":59,"doc-detail-412997-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","mesenchymal-stem-cell-derived-exosomes-a-promising-therapeutic-strategy-for-spinal-cord-injury","Mesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Strategy for Spinal Cord Injury","","Spinal cord injury (SCI) is a central nervous system disorder driven by external forces or pathological processes, with traumatic SCI being the most prevalent. Untreated trauma triggers secondary damage and neuroinflammation, promoting glial proliferation and glial scar formation, which limits functional recovery. Stem cells and their secreted exosomes offer a new therapeutic direction: exosomes are nanoscale vesicles carrying lipids, proteins, and nucleic acids that can support nerve repair across barriers, yet clinical translation remains challenging.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/mesenchymal-stem-cell-derived-exosomes-a-promising-therapeutic-strategy-for-spinal-cord-injury/412997/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/mesenchymal-stem-cell-derived-exosomes-a-promising-therapeutic-strategy-for-spinal-cord-injury/412997.png","ImageObject",300,407,{"name":92,"@type":93},"jay","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",15,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why is secondary injury a major problem in spinal cord injury?","Question",{"text":113,"@type":114},"After the initial trauma, inflammation drives additional neuronal and tissue damage. This promotes glial cell proliferation and glial scar formation, which hinders recovery.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What are exosomes, and how might stem cell-derived exosomes help SCI repair?",{"text":118,"@type":114},"Exosomes are nanoscale vesicles (~30–150 nm) containing lipids, proteins, and nucleic acids. They can influence nerve repair by modulating inflammation, supporting axonal regeneration and angiogenesis, and regulating target cell gene expression through signaling pathways.",{"name":120,"@type":111,"acceptedAnswer":121},"What challenges remain for using exosomes in clinical translation?",{"text":122,"@type":114},"Animal studies show promise, but significant challenges remain, including optimizing exosome production, improving purity, clarifying precise mechanisms of action, and advancing translational applications in patients.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},412997,1790733881,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":46,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":31,"preview_page_count":4},3985747858866,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","International Journal of Nanomedicine  \nOpen Access Full Text Article REVIEW  \nMesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Strategy for Spinal Cord Injury  \nXiaoying Li 1 , Chenchen Wang 1 , Kangchao Du 1 , Jingran Wang 1 , Juntang Lin 1–3 , Ciqing Yang 1 , 2  \n1Stem Cell and Biotherapy Technology Research Center, School of Life Science and Technology, Henan Medical University, Xinxiang, People’s Republic of China; 2Collaborative Innovation Center of Stem Cell and Biotherapy, Henan Province, Henan Medical University, Xinxiang, People’s Republic of China; 3Medical College, Henan University of Chinese Medicine, Zhengzhou, People’s Republic of China  \nCorrespondence: Juntang Lin; Ciqing Yang, Stem Cell and Biotherapy Technology Research Center, School of Life Science and Technology, Henan Medical University, Xinxiang, 453003, People’s Republic of China, Email [developmentlab@126.com](developmentlab@126.com); [yangciqing@126.com](yangciqing@126.com)  \n\n| Abstract: Spinal cord injury (SCI) is a central nervous system injury caused by external forces or pathological factors, and traumatic SCI is the most common. If not treated promptly, traumatic SCI can cause secondary injury and neuroinflammation, leading to the proliferation of glial cells and formation of glial scars. Clinically, SCI is usually treated with surgical intervention, pharmacological therapy, or rehabilitation. However, good outcomes cannot be guaranteed. Therefore, SCI repair remains a central focus in neurotraumatic injury research. With an in-depth study of stem cells in nerve injury repair, stem cells and exosomes secreted by them have brought new hope for SCI treatment. Exosomes secreted by stem cells are small nano-sized vesicles, approximately 30–150 nm in diameter, that contain lipids, proteins, and nucleic acids. They can cross the blood-brain barrier (BBB) or blood-spinal cord barrier (BSCB) through the blood system, and the proteins or nucleic acid molecules they carry promote nerve repair. Existing studies have demonstrated that exosomes exert therapeutic effects on SCI through multiple mechanisms: miRNA-mediated modulation of inflammatory responses, promotion of axonal regeneration and angiogenesis, inhibition of glial scar formation and apoptosis, as well as regulation of target cell gene expression via signal transduction pathways mediated by their carried signaling molecules. Although exosome research has yielded promising results in animal models of SCI, significant challenges remain in their clinical translation. Future research should focus on optimizing exosome production, improving purity, elucidating their precise mechanisms of action, and advancing their clinical translational applications.\u003Cbr>Keywords: spinal cord injury, mesenchymal stem cell, exosomes, therapeutic strategy |\n| --- |\n| Introduction\u003Cbr>Spinal cord injury (SCI) is a central nervous system injury caused by external forces or pathological factors. It is a serious neurological disorder that causes dysfunction of limb movement, sensation, and autonomic nervous system below the site of injury. According to statistics on the Global Burden of Disease (GBD), more than 20.6 million people were affected by SCI worldwide in 2019, with approximately 0.9 million new cases each year.1,2 SCI is usually caused by impact or compression. According to etiological factors, SCI can be divided into traumatic and nontraumatic SCI. Based on pathological changes following injury, SCI can be divided into primary and secondary injuries. Primary injury refers to neuronal damage directly caused by the impact, whereas secondary injury results from inflammation of the spinal cord after the primary injury, which promotes the formation of glial cells and glial scars. The formation of glial scars hinders the development of new neural circuits, making it difficult to fully repair the injured spinal cord, and presents a challenge that needs to be overcome for effective SCI repair. Currently, t","cbCaibnYhOmoO5H9","https://ap.wps.com/l/cbCaibnYhOmoO5H9","pdf",8853540,"English","# Introduction\n## Background and classification of spinal cord injury\n## Current treatments and limitations\n## Rationale for stem cell exosomes","[{\"question\":\"Why is secondary injury a major problem in spinal cord injury?\",\"answer\":\"After the initial trauma, inflammation drives additional neuronal and tissue damage. This promotes glial cell proliferation and glial scar formation, which hinders recovery.\"},{\"question\":\"What are exosomes, and how might stem cell-derived exosomes help SCI repair?\",\"answer\":\"Exosomes are nanoscale vesicles (~30–150 nm) containing lipids, proteins, and nucleic acids. They can influence nerve repair by modulating inflammation, supporting axonal regeneration and angiogenesis, and regulating target cell gene expression through signaling pathways.\"},{\"question\":\"What challenges remain for using exosomes in clinical translation?\",\"answer\":\"Animal studies show promise, but significant challenges remain, including optimizing exosome production, improving purity, clarifying precise mechanisms of action, and advancing translational applications in patients.\"}]","Mesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Strategy for Spinal Cord Injury | PDF",1790593507]