[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-435559-105":59,"doc-detail-435559-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","mepitel-film-or-strataxrt-for-postmastectomy-radiation-dermatitis-current-evidence-and-implications","Mepitel Film or StrataXRT for postmastectomy radiation dermatitis: current evidence and implications","","Acute radiation dermatitis (ARD) is a frequent adverse effect after postmastectomy radiotherapy. Barrier dressings such as Mepitel Film and StrataXRT aim to prevent or reduce severity, but direct comparative evidence remains limited. Recent small, mostly single-center intra-patient studies indicate both interventions help protect against skin toxicity. Evidence synthesis suggests StrataXRT may offer advantages in tolerability, comfort, and application convenience, while Mepitel Film shows slightly greater efficacy for ARD prevention. The letter summarizes emerging comparisons and their clinical and research implications.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/mepitel-film-or-strataxrt-for-postmastectomy-radiation-dermatitis-current-evidence-and-implications/435559/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/mepitel-film-or-strataxrt-for-postmastectomy-radiation-dermatitis-current-evidence-and-implications/435559.png","ImageObject",300,407,{"name":92,"@type":93},"jayni","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-05","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why are barrier dressings like Mepitel Film and StrataXRT used after postmastectomy radiotherapy?","Question",{"text":113,"@type":114},"They are used to prevent or reduce the severity of acute radiation dermatitis, a common and distressing toxicity in breast cancer patients receiving postmastectomy radiotherapy.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What does the referenced randomized non-inferiority trial suggest about Mepitel Film versus StrataXRT?",{"text":118,"@type":114},"In a 2025 intra-patient randomized non-inferiority trial, the time-weighted average grade of ARD favored Mepitel Film, with StrataXRT not meeting non-inferiority criteria.",{"name":120,"@type":111,"acceptedAnswer":121},"How should clinicians consider choosing between these two interventions in practice?",{"text":122,"@type":114},"The letter suggests prioritizing Mepitel Film for higher-risk cases, while considering StrataXRT as a more viable and cost-effective option in broader use, taking facility resources and workflow into account.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},435559,1790876594,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":24,"preview_page_count":4},3985747859343,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Letter to the Editor  \nMepitel Film or StrataXRT for postmastectomyradiation dermatitis: current evidence andimplications  \nSaad Arsalan Wasti, MBBSa , Areesha Wasti, MBBSb , Muhammad Usman Iqbal, MBBSa , Naseeb Danaf, MDc ,*  \nAbstract  \nAcute radiation dermatitis (ARD) is a frequent adverse effect following postmastectomy radiotherapy. Barrier dressings such asMepitel Film and StrataXRT are increasingly used to prevent or reduce its severity, yet comparative data remain limited. Recentstudies, mostly single-center or intra-patient in design with small sample sizes, have demonstrated the effectiveness of both inprotection against skin toxicity, although larger multicenter validation is still needed. Within the current evidence base, StrataXRTshowed advantages intolerability, comfort, and application convenience, whereas Mepitel Film use offered slightly greater efficacyagainst ARD. This letter reviews emerging evidence comparing these two interventions, emphasizing their practical implications forclinical decision-making and future research priorities in ARD prevention.  \nKeywords: mastectomy, Mepitel Film, radiation dermatitis, radiotherapy, StrataXRT  \nDear Editor,  \nAcute radiation dermatitis (ARD) remains one of the mostcommon and distressing toxicities in breast cancer patientsreceiving postmastectomy radiotherapy[1] . Severe radiation der -matitis can disrupt treatment schedules, compromise reconstruc -tion outcomes, and diminish patient quality of life [2] . Thegrowing exploration of barrier prophylactics such as MepitelFilm and StrataXRT reflects a shift toward skin-preserving stra -tegies. However, evidence guiding the optimal choice betweenthese two agents has only recently begun to mature.  \nIn a 2025 intra-patient randomized non-inferiority trial of 44postmastectomy breast cancer patients, alternate chest wallhalves were treated with Mepitel Film and StrataXRT, respec -tively. The time-weighted average grade of ARD over 10 weeksfavored Mepitel Film, with a mean difference of 0.19 (95% CI:0.12 to 0.26, P \u003C 0.001), indicating that StrataXRT did not meetnon-inferiority criteria. While patient preferences were mixed,40% favored Mepitel Film and 37.5% StrataXRT[3] . Similarfindings were seen in a larger intra-patient controlled trial of  \n80 women, where Mepitel Film produced significantly lower  \naDepartment of Medicine, King Edward Medical University, Lahore, Pakistan,bDepartment of Medicine, Continental Medical College, Lahore, Pakistan andcFaculty of Medical Sciences, Lebanese University, Beirut, LebanonSponsorships or competing interests that maybe relevant to content are disclosedatthe end of this article.  \n*Corresponding author. Address: Faculty ofMedical Sciences, Lebanese University,Beirut 1101, Lebanon. Tel.: +961 71164810. E-mail: naseeb.danaf@st.ul.edu.lb(N. Danaf).  \nCopyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc. This is anopen access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where itis permissible todownload and share the work provided itis properly cited. The work cannot bechanged in any way or used commercially without permission from the journal.  \nAnnals of Medicine & Surgery (2026) 88:989–990Received 17 October 2025; Accepted 4 November 2025Published online 22 November 2025http://dx.doi.org/10.1097/MS9.0000000000004327  \nresearcher Radiation Induced Skin Reaction Assessment Scaleand expanded Radiation Therapy Oncology Group scores thanStrataXRT (P = 0.022 and P = 0.011, respectively) . Moist des -quamation rates were modestly lower (6%) with Mepitel Film[4] .A pilot evaluation in Chinese breast cancer patients also foundboth interventions largely safe and tolerable, though MepitelFilm incurred roughly triple the cost due to the requirement ofadditional nursing care fee[5] .  \nNon-comparative evidence also found each product to beeffective. Mepitel Film has consistently reduced grade 2/3 de","cbCait19woINyAIg","https://ap.wps.com/l/cbCait19woINyAIg","pdf",178188,"English","# Abstract\n# Background and rationale\n## Emerging comparative evidence\n# Clinical implications\n# Conclusion and future research","[{\"question\":\"Why are barrier dressings like Mepitel Film and StrataXRT used after postmastectomy radiotherapy?\",\"answer\":\"They are used to prevent or reduce the severity of acute radiation dermatitis, a common and distressing toxicity in breast cancer patients receiving postmastectomy radiotherapy.\"},{\"question\":\"What does the referenced randomized non-inferiority trial suggest about Mepitel Film versus StrataXRT?\",\"answer\":\"In a 2025 intra-patient randomized non-inferiority trial, the time-weighted average grade of ARD favored Mepitel Film, with StrataXRT not meeting non-inferiority criteria.\"},{\"question\":\"How should clinicians consider choosing between these two interventions in practice?\",\"answer\":\"The letter suggests prioritizing Mepitel Film for higher-risk cases, while considering StrataXRT as a more viable and cost-effective option in broader use, taking facility resources and workflow into account.\"}]","Mepitel Film or StrataXRT for postmastectomy radiation dermatitis: current evidence and implications | PDF",1790674167]