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A retrospective cohort (2008–2020) and a nested case–control comparison evaluated associations with careful adjustment for diagnosis timing, treatments, and risk factors. KC history predicted melanoma survival but not CLL and may help identify high-risk asymptomatic CLL.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/melanoma-and-cll-co-occurrence-and-survival-role-of-kc-history/383044/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/melanoma-and-cll-co-occurrence-and-survival-role-of-kc-history/383044.png","ImageObject",300,407,{"name":92,"@type":93},"Kurz","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What question does the study address about melanoma, CLL, and KC history?","Question",{"text":113,"@type":114},"The study examines whether KC history influences survival outcomes for patients with melanoma, CLL, or both, and whether these effects can be separated from other risk factors.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was KC history assessed in relation to survival?",{"text":118,"@type":114},"Researchers conducted a retrospective cohort study (2008–2020) and used multivariable Cox regression models adjusting for diagnosis year, treatment regimens, and other clinical risk factors.",{"name":120,"@type":111,"acceptedAnswer":121},"What were the main survival findings for melanoma versus CLL?",{"text":122,"@type":114},"History of KC was associated with favorable melanoma survival within 4 years after diagnosis, but poorer survival after 7 years; it was not significantly associated with survival following CLL after adjustment.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},383044,1790404548,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},2336478945635,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Zhao et al. BMC Cancer (2023) 23:1084 [https://doi.org/10.1186/s12885-023-11573-z](https://doi.org/10.1186/s12885-023-11573-z)  \nBMC Cancer  \n RESEARCH Open Access  \nMelanoma and CLL co-occurrence and survival: role of KC history  \nYayi Zhao1, Rossybelle P. Amorrortu 1, Sandra C. Stewart2, Kavita M. Ghia3, Vonetta L. Williams3, Vernon K. Sondak4, Kenneth Y. Tsai5, Javier Pinilla‑Ibarz6, Julio C. Chavez6 and Dana E. Rollison 1*  \nAbstract  \nBackground Survival following melanoma and chronic lymphocytic leukemia (CLL) have both been individually associated with previous history of non‑melanoma skin cancers (specifically keratinocyte carcinomas [KC]) . Further‑ more, melanoma and CLL have been reported to occur within the same patients. The survival experience of patients with both cancers is understudied, and the role of history of KC is unknown. Additional research is needed to tease apart the independent associations between KC and CLL survival, KC and melanoma survival, and the co‑occurrence of all three cancers.  \nMethods A retrospective cohort study was conducted among patients who were diagnosed with melanoma and/ or CLL at a comprehensive cancer center between 2008 and 2020. Multivariable Cox regression models were used to examine the association between history of KC and survival following melanoma and/or CLL with careful consider‑ ation of calendar year of diagnosis, treatment regimens and other risk factors. A nested case–control study comparing patients with both CLL and melanoma to those with only CLL or only melanoma was conducted to compare blood parameters across the three groups.  \nResults A time‑dependent association was observed between history of KC and favorable melanoma survival within 4 years following diagnosis and poorer survival post 7 years after melanoma diagnosis. History of KC was not sig‑ nificantly associated with survival following the diagnosis of CLL, after adjustment for clinical factors including histori‑ cal/concurrent melanoma. Patients with co‑occurring melanoma and CLL tended to be diagnosed with melanoma first and had elevated blood parameters including white blood cell and lymphocyte counts as compared with patients who were diagnosed with only melanoma.  \nConclusions History of KC was an independent predictor of survival following melanoma but not of CLL. Additional studies are needed to determine if blood parameters obtained at the time of melanoma diagnosis could be used as a cost‑effective way to identify those at high risk of asymptomatic CLL for the promotion of earlier CLL diagnosis. Keywords Keratinocyte carcinoma, Melanoma, Chronic lymphocytic leukemia, Survival, Cancer diagnosis  \n*Correspondence:  \nDana E. Rollison  \n[Dana. rollison@moffitt.org](Dana. rollison@moffitt.org)  \nFull list of author information is available at the end of the article  \n© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.org/licenses/by/4.0/](http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ()[. The Creative Commons Public Domain Dedication waiver (](http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ()[http://creativecom","cbCaimpozfCOp1pL","https://ap.wps.com/l/cbCaimpozfCOp1pL","pdf",988130,11,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# Background\n## Rationale and prior evidence\n# Methods (study design overview)","[{\"question\":\"What question does the study address about melanoma, CLL, and KC history?\",\"answer\":\"The study examines whether KC history influences survival outcomes for patients with melanoma, CLL, or both, and whether these effects can be separated from other risk factors.\"},{\"question\":\"How was KC history assessed in relation to survival?\",\"answer\":\"Researchers conducted a retrospective cohort study (2008–2020) and used multivariable Cox regression models adjusting for diagnosis year, treatment regimens, and other clinical risk factors.\"},{\"question\":\"What were the main survival findings for melanoma versus CLL?\",\"answer\":\"History of KC was associated with favorable melanoma survival within 4 years after diagnosis, but poorer survival after 7 years; it was not significantly associated with survival following CLL after adjustment.\"}]","Melanoma and CLL co-occurrence and survival: role of KC history | PDF",1790253882,28]