[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-455722-105":3,"detail-sidebar-cat-0-en-105":80,"doc-detail-455722-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":73,"head_meta":75,"extra_data":77,"updated_unix":79},105,"en","medulloblastoma-uses-gaba-transaminase-to-survive-in-the-cerebrospinal-fluid-microenvironment-correction","Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment - Correction","","This document provides a formal correction to the research article titled \"Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination,\" originally published in Cell Reports in 2021. The correction addresses errors identified in Figure 6, specifically regarding legend color mismatches and the display order of merged images. The report includes corrected visual data and analysis demonstrating that increased ABAT expression leads to reduced H3K4ac levels through HDAC3-mediated histone deacetylation, providing insights into medulloblastoma metabolic adaptation and leptomeningeal disease progression.",{"@graph":14,"@context":72},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/medulloblastoma-uses-gaba-transaminase-to-survive-in-the-cerebrospinal-fluid-microenvironment-correction/455722/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/medulloblastoma-uses-gaba-transaminase-to-survive-in-the-cerebrospinal-fluid-microenvironment-correction/455722.png","ImageObject",300,407,{"name":42,"@type":43},"Valentina","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-08","2026-09-30",true,{"@type":52,"interactionType":53,"userInteractionCount":30},"InteractionCounter",{"@type":54},"ViewAction",{"@type":56,"mainEntity":57},"FAQPage",[58,64,68],{"name":59,"@type":60,"acceptedAnswer":61},"What was the primary purpose of this document?","Question",{"text":62,"@type":63},"This document serves as a formal correction for Figure 6 of a previously published research article concerning the role of GABA transaminase in medulloblastoma.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"What biological mechanism is linked to increased ABAT expression in this study?",{"text":67,"@type":63},"Increased ABAT expression is shown to reduce H3K4ac levels through the process of HDAC3-mediated histone deacetylation.",{"name":69,"@type":60,"acceptedAnswer":70},"What specific errors were corrected in Figure 6?",{"text":71,"@type":63},"The corrections included rectifying legend color mismatches in Figure 6B and correcting the display order of DAPI and merged images in Figure 6I.","https://schema.org",{"og:url":32,"og:type":74,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":76,"canonical":32},"index,follow",{"doc_id":78,"site_id":7},455722,1791442546,{"code":4,"msg":81,"data":82},"success",[83,87,91,95,100,105,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":84,"show_sort_weight":85,"slug":86},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":88,"show_sort_weight":89,"slug":90},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":92,"show_sort_weight":93,"slug":94},"Exam",70,"exam",{"id":96,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},5,"Comic",60,"comic",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},6,"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},7,"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":96,"slug":129},19,"General","general",{"code":4,"msg":81,"data":131},{"doc_id":78,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":30,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":30,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":111},13056703020460,"https://ap-avatar.wpscdn.com/avatar/be000253dac470eee5d?_k=1778207105932848923","Author Manuscript Author Manuscript Author Manuscript Author Manuscript  \n\n| | HHS Public Access\u003Cbr>Author manuscript\u003Cbr>Cell Rep. Author manuscript; available in PMC 2026 January 07. |\n| --- | --- |\n\nPublished in final edited form as:  \nCell Rep. 2021 July 27; 36(4): 109475. doi:10.1016/j.celrep.2021.109475 .  \nMedulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination  \nVahan Martirosian, Krutika Deshpande,  \nHao Zhou, Keyue Shen, Kyle Smith, Paul Northcott, Michelle Lin,  \nVazgen Stepanosyan,  \nDiganta Das, Jan Remsik, Danielle Isakov, Adrienne Boire, Henk De Feyter, Kyle Hurth, Shaobo Li, Joseph Wiemels, Brooke Nakamura, Ling Shao, Camelia Danilov, Thomas Chen,  \n*  \nJosh Neman  \nIn the originally published version of this article, there were two errors in Figure 6. In Figure 6B, the legend colors did not match the dataset, and in Figure 6I, the merged image was displayed first, instead of DAPI. The figure has been corrected online, and the original and corrected figures appear below.  \nThe authors regret this error.  \nThis is an open access article under the CC BY license ([http://creativecommons.org/licenses/by/4.0/](http://creativecommons.org/licenses/by/4.0/))  \n*[Correspondence: yebrahim@usc.edu](Correspondence: yebrahim@usc.edu).  \nAuthor Manuscript Author Manuscript Author Manuscript Author Manuscript  \nMartirosian et al. Page 2  \nFigure 6. Increased ABAT expression leads to reduced H3K4ac through HDAC3-mediated histone deacetylation (corrected)  \nCell Rep. Author manuscript; available in PMC 2026 January 07.  \nAuthor Manuscript Author Manuscript Author Manuscript Author Manuscript  \nMartirosian et al. Page 3  \nFigure 6. Increased ABAT expression leads to reduced H3K4ac through HDAC3-mediated histone deacetylation (original)  \nCell Rep. Author manuscript; available in PMC 2026 January 07.","cbCaijZAy1bLU1Au","https://ap.wps.com/l/cbCaijZAy1bLU1Au","pdf",976848,"English","# Correction to Figure 6\n## Original vs Corrected Figures\n## Mechanisms of ABAT-mediated H3K4ac Reduction","[{\"question\":\"What was the primary purpose of this document?\",\"answer\":\"This document serves as a formal correction for Figure 6 of a previously published research article concerning the role of GABA transaminase in medulloblastoma.\"},{\"question\":\"What biological mechanism is linked to increased ABAT expression in this study?\",\"answer\":\"Increased ABAT expression is shown to reduce H3K4ac levels through the process of HDAC3-mediated histone deacetylation.\"},{\"question\":\"What specific errors were corrected in Figure 6?\",\"answer\":\"The corrections included rectifying legend color mismatches in Figure 6B and correcting the display order of DAPI and merged images in Figure 6I.\"}]","Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment - Correction | PDF",1790743983]