[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-421628-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-421628-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","medication-refill-adherence-and-mortality-risk-in-the-oldest-old-study-findings-and-implications","MEDICATION REFILL ADHERENCE AND MORTALITY RISK IN THE OLDEST-OLD - Study findings and implications","","Medication refill adherence is examined as a predictor of all-cause mortality among Medicare beneficiaries aged 85+ with hypertension. A retrospective cohort study used Medicare claims from 2006–2021, defining refill patterns through prescription claims and comparing mortality with Cox proportional hazards models using time-varying exposure. Regular refills were associated with substantially lower mortality risk, similarly for antihypertensive drugs, statins, and proton pump inhibitors, including among ages 95+. Missed refills likely reflect frailty, cognitive decline, or social vulnerability. Pharmacy refill data may support early-risk identification and targeted interventions.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/medication-refill-adherence-and-mortality-risk-in-the-oldest-old-study-findings-and-implications/421628/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/medication-refill-adherence-and-mortality-risk-in-the-oldest-old-study-findings-and-implications/421628.png","ImageObject",300,407,{"name":42,"@type":43},"Quinn Holloway","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",14,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What question does the study investigate?","Question",{"text":63,"@type":64},"The study examines the relationship between medication refill adherence and all-cause mortality in Medicare beneficiaries aged 85+ with hypertension.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was medication adherence measured and outcomes analyzed?",{"text":68,"@type":64},"Refill patterns were derived from Medicare prescription claims and categorized by regular versus missed refill periods. Mortality risk was compared using Cox proportional hazards models with time-varying exposure.",{"name":70,"@type":61,"acceptedAnswer":71},"What do regular versus missed refills indicate about mortality risk?",{"text":72,"@type":64},"Regular refills were linked to a 55–66% lower mortality risk, while missed refills strongly predicted higher mortality, including in those aged 95 and older.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},421628,1791040414,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":22,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":30,"preview_page_count":4},2336474466712,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","200 Innovation in Aging, 2025, Vol. 9, No. S2  \nfor antihypertensive drugs, statins, and proton pump inhibitors (PPIs) were evaluated via prescription claims, categorizing participants into regular vs. missed refill periods. Outcome Measure: All-cause mortality was the primary outcome, with mortality risk compared between refill patterns using Cox proportional hazards models with time-varying exposure. Results: Regular antihypertensive refills were linked to a 55-66% lower mortality risk (HR: 0.336–0.451), consistent even in those aged 95 + (HR: 0.366–0.441) . Similar mortality reductions were seen with statins and PPIs, suggesting refill adherence reflects overall health stability rather than antihypertensive effects alone. Conclusion: Missed refills strongly predict higher mortality in the oldest-old, likely indicating cognitive decline, frailty, or social vulnerability rather than purely pharmacologic factors. Pharmacy refill data could serve as an early-warning tool to identify at-risk older adults for targeted interventions. Further studies should investigate causal pathways and policy implications.  \nAbstract citation ID: igaf122.668  \nMEDICATION REFILL ADHERENCE AND MORTALITY  \nRISK IN THE OLDEST-OLD:  \nRaymond Kheirbek1, Brock Beamer2, Patrick McArdle2, Nadim Ojaimi2, Bernard Davies-Teye3, Abree Johnson3, Farrokh Alemi4, and Raya Kheirbek5, 1. Johns Hopkins University, Baltimore, Maryland, United States, 2. University of Maryland, Baltimore, Maryland, United States, 3. University of Maryland School of Pharmacy, Baltimore, Maryland, United States, 4. George Mason University, Fairfax, Virginia, United States, 5. University of Maryland School of Medicine, Baltimore, Maryland, United States  \nBackground: The U.S. population aged 85 and older is growing rapidly, yet little research explores how medication refill adherence affects mortality in this group. Adherence is critical for managing hypertension and reducing cardiovascular risk, but missed refills may signal broader health, cognitive, or social issues beyond non-compliance. Objective: This study examines the link between medication refill adherence and all-cause mortality in Medicare beneficiaries aged 85+ with hypertension. Design, Setting, and Participants: This retrospective cohort study analyzed Medicare claims data (2006–2021), using a 5% sample (2006–2016) and a 20% sample (2017–2021) of beneficiaries aged 85+ with confirmed hypertension. Exposure: Refill patterns","cbCaigOYZklrEH97","https://ap.wps.com/l/cbCaigOYZklrEH97","pdf",235416,"English","# Background\n# Objective\n# Design, Setting, and Participants\n## Exposure and Outcome Measures\n# Results\n# Conclusion and Implications","[{\"question\":\"What question does the study investigate?\",\"answer\":\"The study examines the relationship between medication refill adherence and all-cause mortality in Medicare beneficiaries aged 85+ with hypertension.\"},{\"question\":\"How was medication adherence measured and outcomes analyzed?\",\"answer\":\"Refill patterns were derived from Medicare prescription claims and categorized by regular versus missed refill periods. Mortality risk was compared using Cox proportional hazards models with time-varying exposure.\"},{\"question\":\"What do regular versus missed refills indicate about mortality risk?\",\"answer\":\"Regular refills were linked to a 55–66% lower mortality risk, while missed refills strongly predicted higher mortality, including in those aged 95 and older.\"}]","MEDICATION REFILL ADHERENCE AND MORTALITY RISK IN THE OLDEST-OLD - Study findings and implications | PDF",1790625284]