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In a discussion at the American Association for the Advancement of Science meeting, Ryan Vandrey explains that the drug cannot be moved to a different schedule until conventional drug development work occurs, but that work is effectively blocked while it remains Schedule I, making large hospital-based Phase III trials extremely difficult. Proposed workarounds include removing scheduling entirely or treating cannabis as a botanical/herbal product, while another approach is waiting for targeted, formulation-based products with defined cannabinoid profiles. 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